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A Case of Hypertrophic Cardiomyopathy Associated with Wolf Parkison White Syndrome

Introduction: There cardiomyopathy hypertrophic ( CMH ) is a structural cell disease cardiac , provider of dead sudden at the house of THE youth of less 40 years old . The association with A syndrome of Wolff - Parkinson -W hite (WPW) was describe but stay However​ rare . We let's report A case of a cardiomyopathy hypertrophic associated has A syndrome of Wolf parkinson white .
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Pulmonary Congestion Dynamics According to Inter-Dialytic Intervals in Hemodialysis

Lung ultrasound (LUS) is reliable in detecting and quantifying of pulmonary congestion in hemodialysis (HD) patients. Pulmonary congestion holds a negative prognostic value in HD patients even when it is asymptomatic. The pathophysiology of pulmonary congestion in HD is complex and includes volume and non-volume dependant factors. We examined the impact of different inter-dialytic intervals on pulmonary congestion by studying its dynamics using lung ultrasou
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Effects of High-Intensity Circuit Training on Body Composition and Selected Cardiovascular Parameters in Overweight and Obese Children Aged 9-12

The problem of excess body weight is becoming an epidemic in the general population, especially among children aged to 12 years old. Efforts are being made to find a way to retreat the unfavorable changes related with obesity. This problem is escalating, and the direction of effective protective actions is not sufficiently recognized. The research presented in this study demonstrate the range of changes in overweight and obese children after an 8 weeks of circuit training program, with simultaneous parental education on modifying their children dietary habits
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Efficacy of Standardized Ginger Extract in Subjects with Occasional Constipation: A Randomized, Double-Blind, Parallel, Placebo-Controlled Study

Occasional constipation is associated with infrequent bowel movement and difficulty in passing stools without any obvious symptoms. Ginger has been used traditionally to manage various gastric conditions like constipation, dyspepsia, belching, bloating, epigastric discomfort, indigestion, nausea, and vomiting. The current study evaluated the effects of a standardized Ginger extract (GE) on objective and subjective markers of occasional constipation in a randomized, double-blind, parallel, placebo-controlled design
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Incessant Supraventricular Tachycardia in a Newborn Treated with Combined Antiarrhythmic Drug Therapy

Supraventricular tachycardia is the most common type of tachyarrhythmia seen in childhood. First-line treatments (adenosine, esmolol-propranolol, digoxin, electrical cardioversion) usually suppress tachycardia, but rarely tachycardia is resistant and requiring Class IC and/or Class III agents, such as amiodarone, sotalol, propafenone, and flecainide.
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Electronic Devices (Wcr) and Covid-19 Vaccine Adr: Myocarditys and Pericarditis - Epidemiology and Physiology of an Interesting Phenomena Hypotesys of Work

Aim of this work is to observe some epidemiological pattern related heart pathology like pericarditis and myocarditis in last decades and the toxicological effect played by various WRC wireless communication radiations as described by scientific literature. All this related the class age distribution of some Rare ADR by various covid-19 vaccines like Pericarditis and miocarditis (more frequent in young) and the use of electronic device WCR among the subpopulation. Of interest to observe that sars cov-2 spike protein, derivates and WCR are able to affect the heart as showed by literature in direct or indirect way. What information can be obtained studing this phenomena?
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A Case Report of ST-Segment Elevation Myocardial Infarction With Non-Obstructive Coronary Artery Disease: an Economical and Beneficial Investigative Algorithm

Myocardial infarction with nonobstructive coronary arteries (MINOCA) is a puzzling clinical entity, coupled with potential multiple pathophysiological mechanisms, often makes disease classification, investigation and management difficult. Despite presence of myocardial damage and increased risk for the future, many patients are discharged undiagnosed, thus the specific cause is not effectively treated.
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Effectiveness of a Community-based Cardiopulmonary Rehabilitation Program to the Elderly Recovered from Coronavirus Disease 2019 (COVID-19

Coronavirus Disease 2019 (COVID-19) is an infectious disease that affects patients’ lung function and thus exercise tolerance. Elderly patients have shown to have more severe and long-term symptoms after contracting COVID-19. Limited evidence has been published on the effectiveness of cardiopulmonary rehabilitation programme for elderly patients recovered from COVID-19. Therefore, the aim of this study was to launch and evaluate the effectiveness of a communitybased cardiopulmonary rehabilitation programme.
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Penicillin-Streptomycin Induces Mouse Embryonic Stem Cells Differentiation into Cardiomyocytes through MAPK signal pathway

Penicillin and streptomycin are the most commonly used to prevent bacterial infection or contamination in cell culture. However, the role of Penicillin-streptomycin on inducing mouse embryonic stem cells(mESCs) to differentiate into cardiomyocytes is unclear. To illustrate the mechanism of penicillin-streptomycin on inducing mESCs differentiation into cardiomyocytes, we firstly investigated mESCs differentiation into cardiomyocytes by the traditional method. The time- space expressions of cardiac-specific genes were detected by real-time PCR and western blotting at 8 different time-points over a period of 36 days. Furthermore, action potentials were measured by patch clamp for mESC-derived cardiomyocytes. Embryonic bodies through hanging drop method, were incubated with penicillin-streptomycin (P/S) at different concentrations (1×PBS, 1×, 2×, 5×), and then, the number of cardiomyocytes and expression levels of myocardial marker proteins were detected by flow cytometry, cellular immunofluorescence, and western blotting, respectively. We found that the SSEA-1 of mESC presented green fluorescence, and H.E. staining showed karyoplasmic ratio >>1. Besides, TNNI3, TNNT2, ACTN2 and MYL-2v were clearly visible by cellular immunofluorescence. Furthermore, the ACTN2 positive cells rate of 2× and 5× groups were remarkably higher than that in Cntl (1×PBS) group and 1× group (10 Units/mL penicillin; 10 μg/mL streptomycin), as well as the expressions of GATA4, MYL-2v, TNNI3, ACTN2
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The Present Scenario of Lathyrisum Regarding Public Health in 2021

Backgrounds: Neurolathyrism is a disease, which is linked with the consumption of Lathyrus sativus ( L. sativusi) pulse that contain the neurotoxin-beta-N-oxalyl-L-alpha-beta-diamino propionic acid (beta-ODAP). Patients with Lathyrisum suffer with gradual enhancement in spasticity and bony changes, which are responsible for appearing the crippling condition throughout life. Objective: The present study has been done as to establish the present situation of L. sativusi consumption and Lathyrisum. Materials and Methods:We performed the survey in the village of Mohammadabad Block of Gazipur district in Eastern Uttar Pradesh (a state with maximum population in India) which have population of million, and L. sativusi is the main pulse of the year, which sustains the economy of these populations. Results:Out of 21,234 subjects L. sativusi eating population for more than 10 years, none had Lathyrisum. On contrary, to popular belief, this population enjoys various dishes made by L. sativusi pulse which in popular are local delicacy. Conclusions:There is no evidence of L. sativusi causing Lathyrisum in 2021. On contrary, L. sativusi pulses have become an inheriting part of the food habits in these populations.
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Benefits and Health Risks Associated with Energy Booster Drinks: A Review Study

There are several energy drinks available in the market such as Red Bull, Sting, Rebound, Power Up! Triple X Energy Drink, and so on. After the Red Bull drink was introduced in the market in1990s, Energy drinks started to gain popularity and afterwards it became a common name especially among teenagers and young adults [1]. Most energy drinks are caffeinated nonindulgent beverages that are professed to give an additional increase in energy for day-by-day work, increase alertness, and improve athletic performance and mood. There are even certain shreds of evidence present to substantiate these claims, but the effects of these drinks on mental and physical health cannot be neglected. There are reports of adverse events such as insomnia, anxiety, cardiovascular events, seizures, tachycardia, type-2 diabetes, and even death are associated with the consumption of these drinks [2]. This review will focus on energy drinks, their ingredients, health risks associated with these drinks, and will also suggest some recommendations such as changes in marketing, providing education to children regarding adverse effects of these drinks, and further research should be carried out in this domain.
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Analysis of Risk Factors of Acute Myocardial Infarction Combined with Ventricular Septal Rupture

A total of 2090 cases of acute myocardial infarction and 63 cases of acute myocardial infarction combined with ventricular septal perforation were collected from Fuwai Huazhong Cardiovascular Hospital from September 2017 to January 2021. 189 cases of type 1 acute myocardial infarction were randomly selected according to the ratio of 1:3 as a control group, the patients collected and analyzed clinical data, the risk factors of AMI and VSR.
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Cardio-Vascular Outcome Assessment of Dual Antiplatelet Therapy beyond 12 Months Following Drug Eluting Stent Implantation - Real World Scenario

In spite of recommendation for antiplatelet therapy following drug eluting stent (DES) implantation, the prescription for antiplatelet therapy in real world clinical practice varies from centre to centre as per physician discretion. The study was intended to assess the cardiovascular outcomes and bleeding complications of dual antiplatelet therapy (DAPT) beyond 12 months following DES implantation.
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Tricuspid Valvulectomy in Drug Addicts with Native Valve Endocarditis: A Case Series

From Jan –2004 to Dec-2004, five patients were referred to the surgical department with a diagnosis of endocarditis refractory to medical therapy. Patients were all male, age ranging 16 years to 28 years with a mean of 22 years. All of the five patients had native valve endocarditis of the tricuspid valve with a history of drug addiction in common. Their presentations included, sepsis, failure and recurrent pulmonary embolism. Three of them had bacterial, while two had fungal infection which was proven after blood cultures. After resuscitation, stabilization and preoperative workup, tricuspid valvectomy was performed on these patients because of the destructive and irreparable nature of the native valve. Fortunately, all had uneventful recovery after surgery. Pre-operatively these patients were treated with antibiotics and antifungals, and continued thereafter for almost 4 to 6 weeks in the post-operative period. Postoperatively there was significant tricuspid regurgitation in a subset of patients who had a follow-up. The Left Ventricular (LV) function remained normal to moderate with a moderate pulmonary artery pressure. These patients were discharged on antibiotics and anti-failure medications as per the GDMT.
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A Case of Frosted-Branch Angiitis Associated with Poststreptococcal Uveitis Syndrome

The case was a 7-year-old girl who had complained of bilateral blurry vision for 1 week. Five weeks earlier, she suffered from a flu-like episode with fever, sore throat, and skin rash, and received an irregular dose of oral amoxicillin for 4 days after a diagnosis of scarlet fever. Our clinical examination revealed bilateral panuveitis with frosted-branch angiitis.
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Editorial Board Members Related to RDI

Douglas Wilson

School Medicine Pharmacy and Health
Durham University

Shereen Mohamed Mohamed Olama

Department of Rheumatology and Rehabilitation
Faculty of Medicine
Mansoura University

Frank F. Seghatol

Assistant Professor
Division of Cardiology
University of Alabama
United States

Jean-François Desaphy

Associate Professor
Department of Pharmacy & Drug Sciences
University of Bari

Richard Lobo

Associate Professor
Department of Pharmacognosy
Manipal College of Pharmaceutical Sciences

Sotiris C. Stamou

Assistant Professor
Department of Cardiothoracic Surgery
University of Iowa Hospitals and Clinics
United States

Shahrel Azmin Suandi

School of Electrical & Electronic Engineering
Universiti Sains Malaysia


Department of Anesthesiology
University of Oklahoma
United States

Solomon Ike Okosun

Associate Professor
Department of Population Health Sciences
School of Public Health
Georgia State University

Abdelwahab Omri

Department of Chemistry and Biochemistry
Laurentian University
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