Acetylsalicylic acid (ASA), a well-recognized non-steroidal anti-inflammatory drug (NSAID), is well known for the treatment of fever, pain alleviation and inflammatory conditions, especially for the prevention of cardiovascular complications and disorders. However, ASA has been reported to cause hepato- and gastro-toxicities.
NIH Funded Articles
- Wake-up Strokes Are Similar to Known-Onset Morning Strokes in Severity and Outcome
- Predictors of Obstructive Sleep Apnea Risk among Blacks with Metabolic Syndrome
- Molecular Mechanism Linking BRCA1 Dysfunction to High Grade Serous Epithelial Ovarian Cancers with Peritoneal Permeability and Ascites
- Acculturation and Subclinical Atherosclerosis among U.S. South Asians: Findings from the MASALA study
- Objectively Coding Intervention Fidelity During A Phone-Based Obesity Prevention Study
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Predicting Multi-Drug Inhibition Interactions based on Signaling Networks and Single Drug Dose-Response Information
Inhibiting multiple pathways/targets with combination drug therapies is widely used to maximize therapeutic benefit in many diseases. Therapeutic success can often be improved by concurrently and/or sequentially inhibiting multiple pathways/targets by combining drugs with different mechanisms of action.
Periodic Micro Hole Texturing with Metal Assisted Chemical Etching for Solar Cell Applications: Dependence of Etch Rate on Orientation
AuthorSurface texturing is an indispensable process for solar cell fabrication. The interaction of the surface with the incoming sunlight is controlled by texturing in such a way that the absorption is maximized through multiple interactions. Wet and dry etching techniques have been used to create textured surfaces on solar cells. Other than standard alkaline texturing used by the industry, metal assisted etching (MAE) appears to be a promising texturing technique with greater potential application for multi-crystalline solar cell fabrication. It is possible to achieve both random and periodic patterns with MAE which is relatively cheaper than dry plasma etching techniques. In this study, periodic hole patterns with micron sized diameters and periodicity were aimed to be achieved.
Gonad removal has been implicated as a risk factor for the development of canine hemangiosarcoma. With gonad removal, there is a loss of negative feedback to the anterior pituitary, resulting in persistently elevated concentrations of luteinizing hormone (LH). LH receptors can be found in gonadal and extragonadal tissues, including the bladder and skin. The aim of this study was to investigate if LH receptors were expressed in canine splenic hemangiosarcoma. Splenic tumor samples submitted to the Oregon State Veterinary Diagnostic Laboratory from referring veterinarians were with routine immunohistochemical methods. In addition, survival time following hemangiosarcoma diagnosis was obtained from the referring veterinarians. Five of the eight splenic hemangiosarcomas (62.5 %) were positive for LH receptor expression. LH receptor cellular localization in splenic hemangiosarcoma was cytoplasmic and granular, similar to the positive control canine skin sections (Figure 1C). There was no positive staining in the negative controls. LH receptor is expressed in a proportion of HSAs but further study need to be done to assess the significance of this finding.