BOTULISM is a neuro-paralytic intoxication illness caused by the ingestion of neurotoxins of Clostridium botulinum with contaminated water or food . The Gram-positive spore-producing bacterium Cl. botulinum is found worldwide and can survive in spore form for up to 30 years in numerous substrates in the environment [2-4]. Cl. botulinum is classified into 7 or 8 different types (A, B, C (C1, C2), D, E, F, G) depending on the antigen properties of the botulinum neurotoxins (BoNT) produced, with intoxication mostly appearing in cattle following the ingestion of neurotoxins of type C and D and, less frequently, of type B [5-9].
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Capsaicin, an active ingredient of Capsicum fruit, is currently undergoing “revival” in the clinical management of pain. However, the choice of its formulation is rather limited to the use of “old-fashioned” tinctures and recently the patches. In an attempt to improve the therapeutic outcome and develop its skin-friendly formulation, we prepared the vesicle-based drug delivery system with capsaicin.
Pharmacy Compounding Quality Control and Pharmaceutical Development Strategies for Seventeen alpha Hydroxyprogesterone Caproate in Prevention of Preterm Delivery
Seventeen alpha hydroxyprogesterone caproate (17-OHPC) is the only FDA-approved drug labeled for prevention of preterm delivery. This drug is also available as a compounded product from licensed compounding pharmacies. This article reviews the FDA approval history and pharmacy compounding quality control data of 17-OHPC, as well as briefly discusses possible future pharmaceutical development strategies for 17-OHPC.
Recently, the pathogenesis of coronary atherosclerosis - a primary cause of cardiovascular disease – studied in a swine model has been investigated by considering in particular the effects of a high cholesterol diet lasting 8 or 16 weeks.