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Articles Related to Clinical

Correlation of Hemostatic Parameters with Poly (ADP-ribose) Polymerase-1 (PARP-1) Polymorphisms, Mutations, Laboratory, and Clinical Characteristics in 114 Patients with Philadelphia-Negative Myeloproliferative Neoplasms

Patients with Philadelphia-negative myeloproliferative neoplasms (PN-MPN) are at a higher risk for venous thrombosis. Thromboelastometry may prove efficient to evaluate the patient’s thrombotic risk. In this study, based on data from 114 patients with PN-MPN from a single center in Greece, hemostatic profile was assessed with routine coagulation tests, Rotational Thromboelastometry (ROTEM® ), and Platelet Function Analyzer (PFA)-100 and correlated with clinical, laboratory, treatment characteristics, gene mutations and polymorphisms of poly (ADP-ribose) polymerase-1 (PARP-1)
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ED Patients with Shock have only Few Clinical Characteristics Related to Etiology

The aim of this study is to describe clinical variables and comorbidities in patients with shock, at arrival to the emergency department, and evaluate the diagnostic validity for different shock etiologies. This was a retrospective cohort study with tertiary analysis of data previously published in two other studies. The study population was all patients with shock, arriving to the emergency department at Odense University Hospital between 2000 and 2011. Shock was defined as systolic blood pressure ≤100mmHg and one or more organ failures. Patients were grouped according to discharge diagnoses and this method was manually validated through patient records. The diagnostic value of 26 clinical variables and 10 comorbidities were described and tested.
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Analysis on Clinical Features and Risk Factors of Death in Yunnan with Acute Mushroom Poisoning

Mushroom poisoning has become a global public health problem. However, effective treatment of toadstool poisoning and risk factors evaluation are a trouble for clinicians. A total of 137 mushroom poisoning cases were reported, of which 70 (52%) were female. Mortality was 13.1% (18). A latency of ≥6 h was seen in 87 cases (63.50%), with a mortality of 89% (16). Direct bilirubin (DB) ≥34.2 μmol/L was seen in 16 patients, and 124 cases (90.0%) occurred from June to August (summer).
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Clinical Stabilization of a Patient with Amyotrophic Lateral Sclerosis Due to Comprehensive Management

Amyotrophic lateral sclerosis (ALS) is a progressive nervous system disease that affects nerve cells in the brain and spinal cord, resulting in paralysis, inevitably, death. We herein report a case of a 67-year-old woman diagnosed with Amyotrophic Lateral Sclerosis (ALS) for one year presented with type II respiratory failure who has been under comprehensive management and kept using Non-Invasive Ventilator (NIV) for more than four months in a stable condition. In this report, we try to discuss the multidisciplinary approach to optimize the functioning of the patients and to care the patients with ALS in order to improve their quality of life (QOL).
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Non-Polio Enterovirus Meningitis in Children-Clinical Spectrum, Viral Serotypes and Outcome: Unusual Community Outbreak Experience at a Tertiary Care Centre from Oman

Enterovirus meningitis is one of the commonest viruses causing meningitis in children which is underdiagnosed. The epidemiology of EV infections is not well studied in the Middle East and Arab Gulf Region. No Study was conducted in Oman to explore more about viral meningitis. This study will help to review enterovirus meningitis in order to guide management and patient care in Oman and will help to decrease the cost of treatment by avoiding unnecessary investigations.
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Case Study: SAT, A New Treatment for Clinical Goat Endometritis

Endometritis is a common disease in peripartum livestock leading to economic losses. A two-year-old, primiparous Egyptian Baladi doe suffered from mucopurulent endometritis. In a standing position using a new treatment called SAT, 10 ml of boiling water (≈100 oC) was slowly injected within the uterine lumen. Peripheral blood and cervical discharge samples were collected before injection (bi) and at 8, 24, 48, 96, 144 and 216 hrs. post injection (pi) and were sent to the lab.
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Drug Therapy Problems and Clinical Outcomes Among Patients with Human Epidermal Growth Factor Receptor 2 (HER2) Positive Breast Cancer on Trastuzumab-Based Therapy in a Kenyan Tertiary Health Facility

Breast cancer ranks first among the most commonly diagnosed cancers in Kenyan females and globally. Treatment is challenging because it is a heterogeneous disease with several subtypes. There has been a significant change in the treatment of Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer subtypes following the introduction and widespread use of HER2 targeted therapies.
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Clinical Features and Management of Eosinophilic Asthma

Asthma is a common chronic airway disease affecting about 334 million people worldwide, and an estimated 7 million children globally. Approximately 10% of patients with asthma have severe refractory disease, which is uncontrolled despite using high doses of inhaled corticosteroids and other modifiers. Among these patients are patients with eosinophilic asthma. Eosinophilic asthma is a phenotype of asthma that is usually very severe and persistent, with frequent exacerbations. It is characterized by the presence of high levels of eosinophils, and CD+4 Th2 cells in the lungs and airways. Eosinophils play a pivotal role in the pathogenesis and severity of asthma. Most patients with eosinophilic asthma respond to the classic stepwise guided treatment. However, 50% of patients with eosinophilic asthma are refractory to corticosteroids and long-acting β2-agonists. Currently, there are targeted personalized biologics for these patients. These biotherapeutics include IgE, interleukin and interleukin receptor monoclonal antibodies,they have added advantageous steroid-sparing effects.
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Epidemiological, Clinical and Radiographic Profile of Thoracic Manifestations Associated with Sickle Cell Anemia in Adults at Teaching Hospital Yalgado Ouédraogo in Ouagadougou at Burkina Faso

Sickle cell anemia is a public health priority, but do its chest manifestations always require a chest radiography ? Our study aims to determine the epidemiological, clinical and radiographic profiles of the thoracic manifestations in the drepanocytic adult in the city of Ouagadougou (BURKINA FASO).
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Cognitive Enhancers Derived from Edible Crops

The concept of an effective cognitive boosting nootropic supplement is gaining traction with consumers, neuroscientists and regulators alike and it is therefore unsurprising that scientifically validated Nootropics are highly prized. New research demonstrates edible crops could be useful sources to mine for new nootropics; plant extracts enriched with an array of cognitive enhancing metabolites. There is merit in investigating these plant species. Metadata has identifies consuming specific fruit and vegetables positively affects cognitive function; therefore these same edible crop plants present as opportunities for developing nootropic formulations. This hypothesis is supported by positive data obtained through clinical testing [e.g. extracts of tomato (Solanum lycopersicum), herbs from the Genus Salvia, cocoa (Theobroma), tea (Camellia sinensisor) and coffee (Coffea Arabica). This review will discuss clinically tested cognitive enhancers derived from edible crop species and discuss their use alongside other classes of nootropics.
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A Case of Lambda AL Type Skeletal Amyloidosis with Vascular Myopathy Achieved Clinical Response after Autologous Stem Cell Transplant

Amyloidosis involving the vascular musculoskeletal system is rare and currently, there is no standard treatment protocol for the treatment of skeletal muscle AL amyloidosis associated with vascular myopathies. Furthermore, the data on the efficacy and safety of autologous stem cell transplant is unclear. In this rare case, a biopsy-proven diagnosis of AL type amyloidosis with an unusual presentation of proximal muscle weakness significantly improved with high dose melphalan followed by autologous stem cell transplantation. The patient achieved and maintained remission for a year post-transplant
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Relationship between Blood Ethanol Concentration, Ethyl Glucuronide and Ethyl Sulfate and Clinical Signs of Alcohol Intoxication

Ethyl glucuronide (EtG) and ethyl sulfate (EtS) are markers for screening previous alcohol consumption and indicating recent drinking in cases of suspicion of driving under the influence of alcohol.
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Clinical Complications, Incidental Neoplasms and Recurrence in Surgical Management of Multi Nodular Goiter

Thyroid tissue samples of 200 patients who underwent total thyroidectomy, near total thyroidectomy and subtotal thyroidectomy for surgical management of multinodular goiter were designed our study. The surgical procedures were performed between January 2016 and December 2018 in general surgery department MUST University. Preoperative ultrasound-guided fine needle aspiration cytology and the postoperative surgical specimens were delivered to pathology lab at MUST University 6th of October city, Giza. Patients with thyroid neoplasms, thyroiditis, toxic and recurrent goiter were excluded from the study. Personal and demographic data were collected and analyzed. Postoperative clinical complications and incidental neoplasms were evaluated. All the patients were followed up over 1 year for expected clinical complications, recurrence of goiter and appearance of neoplasms.
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Clinical Relevance of Serum Retinol in Patients with Cirrhosis of Liver

Vitamin A has multitude of function and liver plays pivotal role in its metabolism. Diseases of liver of various etiology and severity may affect vitamin A status.
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Treatment of Acute Corneal Hydrops with Full-thickness Penetrating Subtotal Keratoplasty (PKP): Clinical Case

The article is devoted to the description of the successful treatment of acute keratoconus by the method of full-thickness penetrating subtotal keratoplasty (PKP).
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Editorial Board Members Related to Clinical

Rafik Ragheb

Program Chair and Faculty for Medical Laboratory
Anderson College
Canada

Nathan Newman

Associate Professor of Athletic Training
Athletic Training Program Director
Drake University
USA

Antonina Argo

Associate Professor
Department of Medical Biotechnology and Forensic Medicine
University of Palermo
Italy

Yun Dai

Associate Professor
Department of Medicine
Virginia Commonwealth University
United States

Akram Asbeutah

Assistant Professor
Department of Radiologic Sciences Jabriya
Kuwait University
Kuwait

John Patrick F. Bebawy

Associate Professor
Department of Anesthesiology
University of Loyola
Chicago USA

Mohemid Al-Jebouri

Professor
Department of Microbiology
University of Tikrit
Iraq

Jeffrey Michael Venstrom

Assistant Professor
Department of Medicine
University of California, San Francisco
United States

MAITRI SHAH

Associate Professor
Department of Obstetrics and Gynecology
Government Medical College
MS University of Baroda
India

MICHAEL VAN DOREN JOHNSTON

Professor
Department of Neurology and Pediatrics
Johns Hopkins University School of Medicine
United States
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