Articles Related to Hemoglobin S
Hemoglobin SC Disease with COVID-19 Presenting with Multiple Infarcts and Acute Splenic Sequestration Crises
Hb SC disease is a type of hemoglobinopathy that can be viewed as a hybrid of hemoglobin S and C. In this disorder there is co-inheritance of one Hbs gene and one HbC gene resulting in a milder phenotype than sickle cell anemia (SCA). Whereas SCA clinical features have been extensively studied, very few studies have been dedicated specifically to HbSC disease as most cases are reported to be silent or of mild severity. As the pandemic continues to evolve with the novel Sars-CoV-2 virus we have learned it can lead to thrombotic complications which could be fatal if not detected early. Of those requiring admission to the intensive care unit, most carry multiple comorbidities (hypertension, diabetes mellitus etc.) leading to worse clinical outcomes. Here, we present a case of a young adult patient with silent hemoglobin SC disease who tested positive for SARS-CoV-2 leading to multiple infarcts, splenic sequestration and respiratory failure. The concurrence of a hemoglobinopathy and COVID-19 should warrant heightened clinical suspicion for unusual outcomes. Hence, providers must remain vigilant while treating any patient with any hemoglobinopathy in the setting of COVID-19.
A One-Year Hospital Based Prospective Study of Sickle Cell Disease from One Capital Area of Kuwait by HPLC
Haemoglobinopathies are inherited disorders of haemoglobin synthesis that are responsible for significant morbidity and mortality all over the world.