Top Links

Articles Related to Interleukin

Interleukins Indicators Impacting the Outcomes of Ischemic Stroke

A prospective clinical cohort study covers 108 IS patients. 93 (86,1%) patients were released from the hospital with improvements, but 15 (13,9%) patients did not survive. The study was carried out in the most acute (1st day of hospitalization) and acute (7 days of hospitalization) phases of the IS. The level of interleukins in blood serum was defined by enzyme immunoassay method.
View complete article: PDF  |  Full-text

Clinical Features and Management of Eosinophilic Asthma

Asthma is a common chronic airway disease affecting about 334 million people worldwide, and an estimated 7 million children globally. Approximately 10% of patients with asthma have severe refractory disease, which is uncontrolled despite using high doses of inhaled corticosteroids and other modifiers. Among these patients are patients with eosinophilic asthma. Eosinophilic asthma is a phenotype of asthma that is usually very severe and persistent, with frequent exacerbations. It is characterized by the presence of high levels of eosinophils, and CD+4 Th2 cells in the lungs and airways. Eosinophils play a pivotal role in the pathogenesis and severity of asthma. Most patients with eosinophilic asthma respond to the classic stepwise guided treatment. However, 50% of patients with eosinophilic asthma are refractory to corticosteroids and long-acting β2-agonists. Currently, there are targeted personalized biologics for these patients. These biotherapeutics include IgE, interleukin and interleukin receptor monoclonal antibodies,they have added advantageous steroid-sparing effects.
View complete article: PDF  |  Full-text

Evaluating the Effect of Oprelvekin on Cardiac Repolarization in Subjects with Chemotherapy-Induced Thrombocytopenia: An Observational Chart Review of a Phase 2 Clinical Trial in Laredo, Texas

This study tested for the cardiac effects of Oprelvekin, recombinant human interleukin-11, a thrombopoietic growth factor, in patients afflicted with chemotherapy-induced thrombocytopenia (platelet count<50,000 cells/ul). Chart-reviews of patients fulfilling the inclusion criteria of: 18-75 yrs of age, non-myeloid malignancy, with adequate hematologic, hepatic and renal parameters and normal electrocardiograms that were enrolled in this phase 2 trial were analyzed. Patients of child-bearing potential agreed to be on a reliable form of birth control for the duration of the study. Results on 4 patients suggest that Oprelvekin does not cause atrial nor ventricular arrhythmia, a rare severe cardiac side effect, in treating patients with chemotherapy-induced thrombocytopenia.
View complete article: PDF  |  Full-text

Mitochondrial Actions for Fat Browning and Energy Expenditure in White Adipose Tissue

White adipose tissue (WAT) is an endocrine organ with crucial role in the development of obesity and related diseases. White adipocytes have less mitochondria than brown adipocytes; nevertheless, there is an increasing body of evidence showing that mitochondrial parameters play a relevant role in WAT physiology, such as proliferation, differentiation and triacylglycerol storage levels.
View complete article: PDF  |  Full-text

Canakinumab in the Treatment of Erosive Hand Osteoarthritis: A Case Series

Erosive hand Osteoarthritis (EOA) is a common and debilitating form of hand OA for which there are no proven or efficacious therapies. Interleukin-1 beta (IL-1β) plays a prominent role in OA joint inflammation. Canakinumab is a selective IL-1β inhibitor.
View complete article: PDF  |  Full-text

Immunosenescence in Humans: Changes to the Aged T Lymphocyte Population in Response to Persistent Cytomegalovirus Infection

Immunosenescence describes the decrease in immune function with advancing age, a phenomenon that is associated with changes in the B and T lymphocyte populations. CD8+ T cells display the most dramatic phenotypical and functional changes within the T cell compartment whereby the cohorts of effector and memory T cells expand while the total population and diversity of naive T cells both decline.
View complete article: PDF  |  Full-text

The Effect of Interleukin-6-Type Cytokines and Adiponectin on MAPK Activation in the Immortalized Human Chondrocyte C28/I2 Line and Normal Human Chondrocytes

The C28/I2 line of immortalized juvenile human chondrocytes was employed to determine the extent to which recombinant human (rh) interleukin-6 (rhIL-6), the interleukin-6-like cytokine, rh-oncostatin M, and the adipokine, rh-adiponectin, activated extracellularsignal regulated kinase (ERK1/2), p38α mitogen-activated protein kinase (p38α MAPK) and c-Jun-amino-terminal kinase (JNK).
View complete article: PDF  |  Full-text

Evaluation of The Immunomodulatory In Vivo Activity of Laminaria Hyperborea Fucoidan Relative to Commercial (1,3/1,6)-Β-D-Glucans from Yeast and Mushrooms

A fucoidan with high ester sulfate content (38-40% by weight) has been isolated in a commercial scale process from Laminaria hyperborea harvested from the western coast of Norway. This is the first characterization of a fucoidan from this species of macroalgae. Ultra purified samples with negligible endotoxin levels were evaluated for cytokine expression in cultured human mononuclear cells.
View complete article: PDF  |  Full-text

Beta (1-3)(1-6)-D-glucan with strong effects on immune status in chicken: potential importance for efficiency of commercial farming

In face of the challenge of the emergent new diseases and the current efforts of the governments to ban growth-promoting antibiotics and to improve conditions and overall health of the farmed animals, new opportunities are created for natural, highly effective, cost affordable immunomodulators.
View complete article: PDF  |  Full-text

The Fatal Alcoholic Ketoacidosis as a Dilemma in the Differential Diagnosis in Unexpected Deaths

48-years old man was found dead at home, lying in his bed. There was a bucket with liquid vomited remnants with no addition of fresh or digested blood found near the bed and an empty bottle of alkaline mineral water often used to attenuate the gastric pain.
View complete article: PDF  |  Full-text

New Adipocytokines

They are cytokines secreted by adipose tissue considered to be immunomodulating agents, however they can be more accurately put into the larger, growing list of adipose-derived hormones.
View complete article: PDF  |  Full-text  | Digital
 
 

Thoroughbred Race Horses Management: A Key Role of the Veterinarian

The veterinarian must confront many situations when working with thoroughbred horses in which he must solve and make decisions that lead to balance between the animal and trainer / owner of the horse, the above should be resolved in an ethical and professional manner.
View complete article: PDF  |  Full-text  | Digital
 
 


Editorial Board Members Related to Interleukin

Mahmoud Younis Mohammed Taha

Department of Dental Basic Sciences
College of Dentistry
Mosul University
Iraq

Jonathan R. Keller

Principal Investigator
Hematopoiesis and Stem Cell Biology Section
Center for Cancer Research
National Cancer Institute
United States
Submit Manuscript


Open Access Journals

View All Journals