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Articles Related to asthma

Clinical Features and Management of Eosinophilic Asthma

Asthma is a common chronic airway disease affecting about 334 million people worldwide, and an estimated 7 million children globally. Approximately 10% of patients with asthma have severe refractory disease, which is uncontrolled despite using high doses of inhaled corticosteroids and other modifiers. Among these patients are patients with eosinophilic asthma. Eosinophilic asthma is a phenotype of asthma that is usually very severe and persistent, with frequent exacerbations. It is characterized by the presence of high levels of eosinophils, and CD+4 Th2 cells in the lungs and airways. Eosinophils play a pivotal role in the pathogenesis and severity of asthma. Most patients with eosinophilic asthma respond to the classic stepwise guided treatment. However, 50% of patients with eosinophilic asthma are refractory to corticosteroids and long-acting β2-agonists. Currently, there are targeted personalized biologics for these patients. These biotherapeutics include IgE, interleukin and interleukin receptor monoclonal antibodies,they have added advantageous steroid-sparing effects.
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Discovery of Potent Drug Candidates of Adhatoda vasica Against Target Proteins IL- 4 and IL- 13 of Asthma – An in Silico

Bronchial-Asthma, Adhatoda-vasica, In-Silico, IL- 13, IL- 4
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Oral Health in Asthmatics: A Review

Asthma is a chronic inflammation of airway tract characterized by airway obstruction and hyper responsiveness presenting with symptoms of wheezing, coughing, chest tightness and dyspnoea. It is a serious health issue with the worldwide occurrence. Antiasthmatic drugs have unfavorable effects on oral health causing dental caries, xerostomia, dental erosion, periodontal disease and orofacial deformities. This review concludes that asthma drastically affects oral health but preventive measures can help to improve quality of life.
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Effects of Transfer Point Glucan #300 Supplementation on Children exposed to Passive Smoking - Placebo-driven Double-blind Clinical Trials

In this study, we focused on the effect of β-glucan supplementation of children with chronic respiratory problems. We measured the levels of cortisol, salivary IgE and cotinine in 56 children and evaluated the effect of 30 day supplementation with 100 mg/day oral dose of yeast-derived β-glucan. Our results showed strong decrease of cotinine and cortisol levels in saliva of β-glucan-supplemented children.
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Reduction of Bitterness and Enhancing Palatability of Cetirizine Oral Liquid Dosage Forms by Cyclodextrins

The aim of this manuscript is to study cyclodextrins (CDs) as a potential excipient to suppress bitterness and enhance palatability of pediatric liquid preparations for Cetirizine, an extremely bitter drug. Natural α, β and γ CDs; and β CD derivatives such as hydroxyl propyl (HP), randomly methylated (RM) and sulfobutyl ether (SBE) β-CDs were screened in different molar ratios of 1:1, 1:2 and 1:3 for their inhibition of the extremely bitter taste of Cetirizine using the human gustatory sensation test.
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Editorial Board Members Related to asthma

Grant Dewson

Laboratory Head
Cell Signalling and Cell Death Division
Walter & Eliza Hall Institute of Medical Research
Australia

Muhammad Nasir Afzal

Professor & Director
Department of physiology
College of Medicine, Alfaisal University
Saudi Arabia

VICTORIA J VIEIRA-POTTER

Assistant Professor
Department of Nutrition and Exercise Physiology
University of Missouri
United States
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