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Double Stroke and Double Malignancy: A Case Report

Stroke associated with malignancy is rapidly increasing. Lesion types mainly resemble cardio embolic multiple ischemic lesions. We present a rare stroke patient with both ischemic and hemorrhagic lesions simultaneously. The etiology of stroke was found to be due to lung cancer and essential thrombocytosis. Differential diagnosis in this case can help for further investigation of strokes with malignancy.
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Familial Hypokalemic Periodic Paralysis with Myotonic Phenomenon : Case Report

Hypokalemic Periodic Paralysis (HypoPP) is a rare disease whereby voltage-gated ion channels are mutated and it is characterized by episodic flaccid paralysis concomitant to variations in blood potassium levels. Attacks usually happen after exercise or high carbohydrate meals. The diagnosis is made with laboratory data which helps to exclude other causes and confirm low serum potassium or myotonia on eletromyography (EMG).
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Bullous Lichen Planus: A Case Report with Review of Literature

Oral lichen planus is a chronic inflammatory mucocutaneous disease which frequently involves the oral mucosa. A 48-year-old male patient with the chief complaint of burning sensation in bilateral buccal mucosa, upper and lower labial mucosa diagnosed as Bullous lichen planus and treated with systemic prednisolone and Benzydamine oral rinse. Patient was followed for 6 months and was almost free of lesions. The case is reported with review of current modalities in the management of oral lichen planus.
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Atypical Granulomatous Lesion of Gingiva: A Case Report on Rare Manifestation of Tuberculosis in Oral Cavity

Primary tuberculosis lesion in oral cavity is a rare clinical entity. We report a case of gingival tuberculosis manifested as chronic ulceration with pus discharge.
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Primary Osteosarcoma of the Nasal Fossa: An Exceptional Presentation

Sarcomas of the head and neck are very rare accounting for approximately 1% of all head and neck neoplasms. Primary osteosarcomas of the nasal cavity are less than 0.5% of the osteosarcomas occur in this location. Because of the rarity of this presentation, we report a case of a 54 year old male with primary osteosarcoma arising de novo from the nasal cavity, presented with left epistaxis and bilateral nasal obstruction.
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Adenomatoid Odontogenic Tumor: Case Report

Adenomatoid Odontogenic Tumor (AOT) is a benign tumor, most common in the maxilla, characterized by slow, progressive, painless growth of firm consistency, the size of which usually does not reach large proportions.
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Ectopic Intra-Nasal Tooth: A Case Report

An ectopic tooth in a nasal cavity is a rare phenomenon. In most cases, no etiological explanation of teeth in that location has been suggested or found. We report the case of a 26-year-old man, who discovered, 5 years ago, an induration inside his right nasal pit, which caused an unilateral nasal obstruction, without rhinorrhea, with epistaxis, revealing an ectopic in intra-nasal tooth.
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Splenic Injury after Screening Colonoscopy; Could that Happen Twice? An Unusual Case Report

Iatrogenic splenic injury is a known but rare complication of colonoscopic procedures. Our department describes a very interesting case of the same complication that occurred twice on the same patient. The patient had an elective colonoscopy for microcytic anemia and shortly after the endoscopic procedure she developed excessive abdominal pain and had a syncope episode. She gradually became hemodynamically unstable and needed proper resuscitation. An abdominal tomography scan performed which surprisingly demonstrated active intra-abdominal bleeding pointing a ruptured spleen as the source of the hemorrhage. This finding surprised us given the fact that her past surgical history included a previous splenectomy for the same complication 14 years ago.
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Poor Metabolic Quality Embryo is Capable to Implant – A Case Report

There has been little advance in embryo selection criteria since the first IVF. To this day, we select embryos by morphological criteria, which provide little information as to the actual embryo quality.
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Treating Refractory Myasthenia Gravis with Rituximab – Case Report

Myasthenia gravis is an autoimmune disease characterized by motor plaque dysfunction due to antibodies against post-synaptic membrane proteins. Myasthenic symptoms classically wax and wane and are more intense at the end of the day, although they may be constant in severe pictures. Almost every patient have eyelid ptosis and double vision, and the majority of them also have proximal muscle weakness. Reversible cholinesterase inhibitors are the first-line treatment, but patients who do not achieve symptom control should receive immunosuppressive therapy, whose options include azathioprine, cyclosporine, mycophenolate, intravenous immunoglobulin and thymectomy, with different profiles of efficacy, safety and tolerability.
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Novel analytical technologies of Quality in the Sheep & Goat Dairy Sector

France, Greece, Italy, and Spain the major sheep and goat milk producers in Europe, got the initiative through an interim of 30 years (1985 – 2015), to organize - through IDF - 7 symposiums aiming at the upgrade of the Dairy Sector. One major interest was the milk quality. Stepwise, the efforts followed cow milk structural development in organizing the testing laboratory, the definition of quality in composition (fat, protein, lactose, total solids), in Hygienic (Total Bacteria Count, Somatic Cell Count, antibiotics residues and Aflatoxin M1 contamination), adulteration with water and detection of milk species. EU, by Decision 2002/657/EC, defined the rules for the Directive 96/23/EC, enumerated the testing methods, the demands in sampling procedures, the minimum limits of performance, the quality control (ISO 17025) and the interpretation of results. The equivalency of results from different laboratories, through ISO 17025, demanded the application of ISO analytical standards.
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A Case of Solitary Fibrous Tumor of the Mesorectum: Usefulness of Immunohistochemical Staining for a Differential Diagnosis from a Gastrointestinal Stromal Tumor

Extrapleural solitary fibrous tumors (SFT) and gastrointestinal stromal tumors (GISTs) are similar morphologically and on imaging studies. We report a case of a patient with a giant pelvic tumor, which was difficult to be diagnosed. A 71-year-old male presented to our hospital with a complaint of urinary retention. A radiological examination showed a giant pelvic tumor mass, which ventrally compressed the urinary bladder and rectum, and was supplied by vascular flow from the right internal iliac artery. The resected specimen was 15 × 10 cm, elastic soft, and solid pale yellow in color. Because the tumor was histologically composed of spindle-shaped cells and was CD34 positive, cytokeratin negative, epithelial membrane antigens negative and KIT negative, we first thought the tumor was a KIT-negative GIST.
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A Rare Case Report of Primary Pure Pleomorphic Liposarcoma of Breast with Cytological and Histopathological Findings

Sarcomas of a breast are rare tumors. Primary mammary liposarcomas are rarer still. The peak incidence of breast liposarcomas in adults occur between 4th and 6th decades. We report a case of primary breast pleomorphic liposarcoma in a 70 years old female patient. FNAC of the tumor was non-specific. However, histopathological along with immunohistochemical studies clinched the diagnosis.
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Quadrivalent Human Papillomavirus Vaccine and the Young Ovary: Review of Safety Research Following Two Case Series of Premature Ovarian Insufficiency

The quadrivalent virus-like particle vaccine against human papillomavirus (QHPV) is a population vaccine targeting peri-pubertal girls and boys. Focus on evaluation of adolescent ovarian safety arises from cases in primary care and published case series describing the development of menstrual dysfunction and idiopathic premature ovarian insufficiency (POI) following QHPV vaccination. A structured review of QHPV vaccine safety studies was performed to answer the question ‘has the ongoing ovarian safety of this vaccine in adolescents been assessed?’ The design, size, and process of pre-licensing safety trials in relation to their capacity to assess ovarian function were reviewed.
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A Case of Bulbar Amyotrophic Lateral Sclerosis with Mild Cognitive Impairment

It is still contentious whether amyotrophic lateral sclerosis (ALS)-Alzheimer’s disease (AD) cases comprise a combined disease or represent a coincidental association. We describe the case of a 78-year-old white male with a 12-month history of bulbar muscle weakness and mild cognitive impairment. Hallmarks of AD pathology were present and associated with diffuse congophilic angiopathy. The motor cortex did not show a loss of motoneurons. The anterior horns of the medulla oblongata and hypoglossal nuclei showed skein-like cytoplasmic inclusions and ubiquitin and TDP43 phosphate positive staining. No signs of FTLD were detected. The pathological results suggest that, in this case, ALS and AD pathology appeared to be independent.
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Editorial Board Members Related to case

Ana Cristina Lindsay

Associate Professor
Department of Nutrition
University of Massachusetts Boston
United States

Gillian Tully

Director
Principal Forensic Services Ltd
United Kingdom

Charles J. Malemud

Professor
Department of Medicine and Anatomy
Case Western Reserve University
United States

Wen-Quan Zou

Associate Professor
Departments of Pathology and Neurology
Case Western Reserve University School of Medicine
United States

Jack Ho WONG

Research Associate
School of Biomedical Sciences
Faculty of Medicine
The Chinese University of Hong Kong
Hong Kong

Lan Zhou

Assistant Professor
Department of Pathology
Case Western Reserve University
United States

Wen-Quan Zou

Associate Professor
Departments of Pathology and Neurology
Case Western Reserve University School of Medicine
United States

Lufang Zhou

Lufang Zhou
Assistant Professor
The University of Alabama
Birmingham
United Kingdom

NABIL F. BISSADA

Professor
Department of Periodontology
School of Dental Medicine
Case Western Reserve University
United States

Guey-Jen Lee-Chen

Professor
Department of Life Science
National Taiwan Normal University
Taiwan
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