Articles Related to dh
Haosmc Growth on Various Sustainable Nano/Micropatterned Surface Topographies Utilising Reusable Surface Templatin
The aim of controlling/regulating cellular processes by surface patterning of biomaterials is a crucial concept in emerging research fields, where the precise fabrication of micro-nano surface topographies is required at manufacturing scales to meet
consumer demand. Photolithography is typically employed for surface patterning; however, the high cost, process complexity, and lack of environmentally friendly and sustainable methodologies represent steep barriers for many researchers. Soft
lithographic methods have been utilised extensively as a potential alternative for traditional photolithography, yet a photolithographic step is still required for initial template fabrication. Here, we demonstrate the use of repurposed optical consumer items such as DVDs, diffraction glasses, and gratings that would otherwise be thrown away after their useful lives, being used here as a sustainable approach as templates for the formation of complex nano-patterns. By replicating these templates in polydimethylsiloxane (PDMS) and polylactic acid (PLA), we show the varied interactions of human aortic smooth
muscle cells (HAoSMC) to these surfaces. Notably, it was demonstrated that, in comparison to nonpatterned substrates,
HAoSMC interaction (adhesion, spreading, and viability) was higher on DVD patterned surfaces compared to diffraction
glass and grating patterned surfaces according to the results from cell metabolic activity (MTT and Alamar Blue), and proliferation (total DNA) assays. We demonstrate that a simple, reusable, inexpensive, yet robust technology could be a powerful
tool in improving our understanding of cell-surface interactions and for the potential development of medical devices with
micro- and nanoscale low or high adhesion features
Adherence to Antiretroviral Medication and Factors Affecting it Among HIV-- Positive Patients Receiving it at Adama General Hospital
Before the development of highly active antiretroviral medication, AIDS and related illnesses caused a great deal of suffering and death. All of the AIDS-related morbidities and mortality have considerably decreased thanks to modern medication, especially in industrialized nations. However, this accomplishment is still elusive in underdeveloped nations, particularly in those in sub-Saharan Africa. This failure can be attributed to a number of factors. Poverty, ignorance about the treatment, and inadequate therapy adherence are at the top of this list.
Denture Barcoding - The Clever Way
Forensic Odontology is the means to identify a person from their dental remains. Various methods are there for identifying an individual. In this study, the main aim is to identify an edentulous person making a positive identification by means of Barcode. A Barcode is a machine-readable code in the form of numbers and a pattern of parallel lines of varying widths, printed on a commodity. The study focuses on creating dentures with identification marks/labels using patient’s identity proofs such as Aadhar Card, PAN card, Voter ID card. And these will be incorporated in the denture after acrylization using cost effective and minimally altering method. This is an attempt to incorporate identity marks in dentures that can be provided by a General Dental Practitioner on day-to-day basis.
Mucoadhesive Drug Delivery Systems-An Overview
The term mucoadhesion can be defined as a phenomenon of interfacial molecular attractive forces in the layer of surface of a biological
membrane and the natural or synthetic polymer, which allows the polymer to the adhere the surface of that membrane for an extended as well
prolonged period of time. Since the last four decades, the conception of mucoadhesion has achieved a important precious interest in the
various fields of pharmaceutics
Ergonomics improvement in a dairy manufacturing plant comparing a voice feedback system that replaced a wireless handheld system
The study reports on improved order selection ergonomics, feedback delivery, productivity, and worker satisfaction by
replacing a wireless handheld device system with a voice feedback system. ‘Order selectors’ at a dairy manufacturing plant
are tasked with selecting dairy products for store orders (e.g. grocery stores, convenience stores). In the new voice feedback
system, workers listened to instructions via a headset and spoke directly into a microphone, receiving immediate voice
feedback.
Short-Term Usage Time and Rate of CPAP Predict Long-Term CPAP Adherence in Patients with Obstructive Sleep Apnea
Objective: Obstructive sleep apnea (OSA) is a highly prevalent disease associated with various morbidities worldwide.
Although continuous positive airway pressure (CPAP) is the cornerstone of therapy, adherence to CPAP directly affects
its efficacy. Methods: We retrospectively investigated consecutive patients who were diagnosed with OSA and placed on CPAP the-
rapy within an approximate ten-year period. Using patient characteristics and short-term usage, the predictors of adhe-
rence to CPAP were evaluated.
Level of Adherence to Antiretroviral Therapy Among People Living with HIV/AIDS in Ekiti State
Introduction: The use of anti-retroviral drugs slows down disease progression in Human Immunodeficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS) and this has improved the quality of life and life expectancy of Persons Living with HIV/AIDS (PLWHA). However, optimum use of antiretroviral drugs (adherence) by PLWHA is the key to achieving viral load suppression and preventing drug resistance in them.
Objective: This study determined the level of adherence to Anti-Retroviral Therapy (ART) among PLWHA in Ekiti State.
Methodology: A cross-sectional study was conducted on 320 PLWHA in Ekiti State University Teaching Hospital, Ado-Ekiti and 300 PLWHA in Federal Teaching Hospital, Ido-Ekiti aged 18 years and above using ARV for at least six months prior to the study. Quantitative data were collected from the participants using a structured questionnaire while sixteen in-depth interviews were conducted among purposively selected PLWHA in both study centres to further elicit qualitative information on determinants of adherence. Quantitative data were analyzed with SPSS 22 using descriptive statistics while content analysis was used for qualitative data. Regression analysis was done to identify determinants of adherence at p value < 0.05.
Results: About 60% of the PLWHA had high level of ART adherence while 18.9% had low adherence. Most of the respondents were female (66.0%), married (76.1%) and Christians (89.4%) and had post-secondary education (43.4%). Respondents’ age (X2=32.483), educational status (X2=2.473), marital status (X2=40.083), occupation (X2=57.951) and distance from the clinic (X2=13.181) significantly influenced the level of adherence. Patient factors such as forget timing of the medication, pill burden and feeling better, psychosocial factors like stigmatization, non-disclosure of status and depression; and healthcare factors such as long clinic waiting time and absence of support are some of the barriers to optimum ART adherence.
Conclusion: Counseling on drug adherence and psycho-social support to PLWHA will further improve their level of adherence to medication.
Factors Influencing Adherence to Hydroxyurea Treatment Among Children with Sickle Cell Disease at the Mother and Child Center of the Chantal Biya Foundation
Introduction: Sickle cell disease (SCD) is a genetic hemoglobin disease for which there are many treatment options. Evidence supports the efficacy and cost-effectiveness of hydroxyurea (HU). Nevertheless, its use and adherence to treatment remain suboptimal, hence, the necessity to assess the factors influencing this observance.
Objectives: The objective was to evaluate the factors influencing observance to HU in children with sickle cell disease from the Mother and Child Center of the Chantal Biya Foundation (MCC of the CBF).
Materials and Methods: This was a descriptive and analytical cross-sectional study from January to June 2020. Children on HU for at least six months, and followed up at MCC of the CBF were included. Data collection was done using a pre-tested questionnaire. The level of compliance was assessed using the Morisky’s observance grid, where 8 points was considered as “good”; 6-7 points as “fair”, and <6 as “poor”. Data were stored in CSPro version 7.0 software, and subsequently analyzed using the SPSS version 20.0 software.
Results: Of 142 patients recruited, the level of patient observance was considered “good” in 2.1%, fair in 26.1% and poor in 71.8%. Logistic regression analyses suggested that using hydroxyurea to prevent complications was the only factor that favored good medical adherence [OR=0.37; CI (0.14-0.987)] (p=0.047). Poor compliance was mainly associated with the fear of infertility and and other sides effects associated with the use of HU.
Conclusion: Children with SCD in this study have poor compliance with HU. Implementing IEC sessions would make it possible to raise patient/parent awareness and reverse this trend.
Therapy-related Myeloid Neoplasms after Pediatric Solid Cancer in a Single Reference Cancer Center in Brazil
Pediatric cancer overall survival has increased due to improvements in treatment. However, long-term adverse effects are a challenge for this population. Secondary myeloid neoplasm (MN) is one of the complications of solid tumor treatment. Therapy-related myeloid neoplasms (t-MN), therapy-related acute myeloid leukemia (t-AML), and therapy-related myelodysplastic syndrome (t-MDS) are the most common events. The aim of this study was to report a large pediatric sample and the relevance of t-MN after pediatric solid tumor therapy. We conducted a retrospective study between 2000-2016 in a cohort of pediatric patients treated for solid tumors who developed a secondary MN by medical records review and analysis. Seven from 2178 pediatric patients who were previously treated for solid tumors, were diagnosed with t-MN in a reference cancer center in Brazil. The median age at primary tumor diagnosis was 12.8 years old. Osteosarcoma, atypical primitive neuroectodermal tumor (PNET), Ewing sarcoma, and retinoblastoma were the most frequent solid tumors associated with t-MN. Three patients had a story of familiar cancer, and one patient with osteosarcoma had Li-Fraumeni syndrome confirmed. The median latency period to secondary MN was ten months and the prevalence rate was 0.32%. Two patients developed t-MDS and five, t-AML. All these patients received cytotoxic agents’ high doses that may have been associated with t-MN development. t-MN initial control, as well as unfavorable cytogenetic abnormalities, may have contributed to the poor outcome. We described the rarity of t-MN related to previous solid tumor therapy in a large pediatric sample in a Brazilian Cancer Center and their poor prognosis.
Treatment of Erdheim-Chester Disease with High Dose Pegylated IFN-α: a Case Report and Literature Review
Erdhein-chester disease is a rare non-Langerhans histocytes that can involve multiple systems, with bone involvement as the most common. We reports a 39-year-old female who visited the hospital due to pain in both lower limbs, combined with clinical manifestations, imaging, and laboratory tests, Erdhein-Chester disease was prelimi narily diagnosed. The diagnosis was confirmed by the presence of BRAF V600E mutation and tissue cells on biopsy of the right tibia. We discussed the disease based on literature review, aiming to improve the understanding of clinicians.
ABHD6 Inhibition Rescues a Sex-Dependent Deficit in Motor Coordination in The HdhQ200/200 Mouse Model of Huntington’s Disease
Huntington’s Disease is associated with motor behavior deficits that are lessened by few therapeutic options. This preliminary study tested if pharmacological inhibition of α/β-hydrolase domain containing 6 (ABHD6), a multifunctional enzyme expressed in the striatum, rescues behavioral deficits in HdhQ200/200 mice.
Forensic Medical Aspect in Siddha Medical System-Comparative Study
Siddha medical system is creating to re-erect of whole world by their facts on human being of health status of living now.
Can Myofascial Treatment with Pulsating Vibrations Improve Mobility for Patients with Frozen Shoulder? A Case Study
Thousands of patients are annually diagnosed with Frozen Shoulder (FS) or adhesive capsulitis, where the joint capsule contracts and becomes less flexible. The condition is painful, with reduced range of motion (ROM) in the shoulder and arm and causes great suffering, often with difficulty sleeping and greatly reduced work ability. The treatment given today is partly conventional treatment with cortisone or NSAID preparations as well as physiotherapy and other therapeutic treatment which usually have limited effect. The study investigates whether myofascial treatment, using a device generating deep pulsating vibrations, can provide increased ROM and facilitate for these patients. 23 patients diagnosed with FS were included in the study. Three treatments were performed, within set time intervals. The ROM was measured before and after each treatment, pictures were taken with a thermography camera and angles were measured. The result showed that 87 percent got an increased ROM by 30 degrees or more, that 52 percent of the patients improved
ROM by 60 degrees or more, and that 30 percent regained full ROM. 61 percent of the patients also reported improved quality of sleep. The study indicates that this treatment could possibly improve ROM and well-being for patients with FS. Further studies are recommended to evaluate and validate these findings. A validated treatment of FS could mean great socioeconomic benefits and an increased quality of life for patients diagnosed with FS.
Discovery of Potent Drug Candidates of Adhatoda vasica Against Target Proteins IL- 4 and IL- 13 of Asthma – An in Silico
Bronchial-Asthma, Adhatoda-vasica, In-Silico, IL- 13, IL- 4
Preparation and Performance Analysis of High Temperature Resistant and High Strength Alcohol Soluble Phosphate/Phenolic Hybrid Adhesive
A kind of alcohol-soluble phosphate adhesive was prepared by using phosphate solution as raw material. A hybrid high temperature and high strength adhesive was prepared by adding phenolic resin. The wetting condition of water-soluble and alcohol-soluble phosphate adhesive on the surface of hydrophobic material, the composition and mechanical properties of the adhesive were analyzed by means of liquid drop shape analyzer (DSA), X-ray diffraction instrument and universal tensile force machine. The results show that the
alcohol-soluble phosphate adhesive has good wetting effect on hydrophobic materials and has excellent high temperature resistance and mechanical properties.
Editorial Board Members Related to dh
Jiban Shrestha
Scientist
Nepal Agricultural Research Council
National Commercial Agriculture Research Program
Nepal
Nepal Agricultural Research Council
National Commercial Agriculture Research Program
Nepal
SANJEEV KUMAR SINGH
Professor
Department of Bioinformatics
Alagappa University
India
Department of Bioinformatics
Alagappa University
India
Ana Rita Ramalho Figueiras
Faculty of Pharmacy
University of Coimbra
Portugal
University of Coimbra
Portugal
VOJTECH HAINER
Associate Professor
Institute of Endocrinology
Obesity Management Center
Prague
Czech Republic
Institute of Endocrinology
Obesity Management Center
Prague
Czech Republic
JOE DEUTSCH
Associate Professor
Department of Health, Nutrition and Exercise Sciences
North Dakota State University
United States
Department of Health, Nutrition and Exercise Sciences
North Dakota State University
United States
RIYADH KHUDHAIR LAFTA AL-JUBOORI
Professor
University of Washington
United States
University of Washington
United States
A. F. M. Motiur Rahman
Associate Professor
Department of Pharmaceutical Chemistry
College of Pharmacy, King Saud University
Saudi Arabia
Department of Pharmaceutical Chemistry
College of Pharmacy, King Saud University
Saudi Arabia
Syed Aitizaz Uddin
Deputy Chief Cardiac Surgery
Pediatric Cardiac Surgeon
Madinah Cardiac Center
Saudi Arabia
Pediatric Cardiac Surgeon
Madinah Cardiac Center
Saudi Arabia
Baljean Dhillon
Professor of clinical ophthalmology
University of Edinburgh
United Kingdom
University of Edinburgh
United Kingdom
Stephen Michael Kavic
Associate Professor
Department of Surgery
University of Maryland School of Medicine
United States
Department of Surgery
University of Maryland School of Medicine
United States