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Mitochondrial Production of Perhydroxyl Radical (HO2 • ) as Inducer of Aging and Age-Related Pathologies

All organisms age, in the search of the universal mechanisms of aging Barja analyzed results obtained with various species of mammals and birds and concluded that only two known factors correlate in the right sense (inversely) with animal longevity in vertebrates: the long life span is associated with (a) low rates of mitochondrial reactive oxygen species production, and (b) low degree of fatty acid polyunsaturation of cellular membranes including the mitochondrial ones [Barja (2014) Prog Mol Biol Transl Sci. 127:1-27].
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Comparison between Polyacid-Modified Composite Resin and Conventional Composite Resin used for Primary Molars Restoration

Ten recently extracted primary molars, were used in this study for the measurement of the shear bond strength. Occlusal enamel was ground, leaving a flat dentin surface, on which a cylindrical specimen of each of the two tested materials was applied and light-cured according to the manufacturer’s instructions. Specimens were then mounted in self-cure acrylic resin. Ten specimens were used for the measurement of the compressive strength. The specimens were prepared in a special-cylindrical mold, then light-cured according to the manufacturer’s instructions. The compressive and shear bond strength of each specimen was measured using a Universal Testing Machine.Ten specimens of each of the two resin materials were used to measure the abrasion resistance. The test was performed by means of a toothbrushing machine and abrasive dentifrice slurry. The specimens were weighed before and after the test. Weight loss of the specimens were calculated after the test and reported as percent weight loss. Regarding microleakage test, Class V cavities were prepared in the buccal surface of 36 exfoliated or extracted human primary molars.
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DNA Polymerase as Therapeutic Intervention for Treating Patients with Multiple Sclerosis

In recent years, increasing evidence has pointed to the potential role of fibrinolysis in the pathogenesis of MS. Based on hypotheses describing the aggressive autoimmune responses observed in MS patients, a result of impaired between (t-PA and PA1-1) which are a key molecules in both fibrinolysis and extracellular proteolysis. The present study was done to investigate the therapeutic potential of polymerase enzyme in modulating the changes occurred between levels of Tissue- type plasminogen activator (t-PA) and its inhibitor (PAI-1) in patients with multiple sclerosis. A pilot study was carried out on a total of twenty-one patients (17 females, 4 males; aged 22-46 years) with demyelination suggestive of MS and clinically silent T2 brain lesions on magnetic resonance imaging (MRI).
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Novel analytical technologies of Quality in the Sheep & Goat Dairy Sector

France, Greece, Italy, and Spain the major sheep and goat milk producers in Europe, got the initiative through an interim of 30 years (1985 – 2015), to organize - through IDF - 7 symposiums aiming at the upgrade of the Dairy Sector. One major interest was the milk quality. Stepwise, the efforts followed cow milk structural development in organizing the testing laboratory, the definition of quality in composition (fat, protein, lactose, total solids), in Hygienic (Total Bacteria Count, Somatic Cell Count, antibiotics residues and Aflatoxin M1 contamination), adulteration with water and detection of milk species. EU, by Decision 2002/657/EC, defined the rules for the Directive 96/23/EC, enumerated the testing methods, the demands in sampling procedures, the minimum limits of performance, the quality control (ISO 17025) and the interpretation of results. The equivalency of results from different laboratories, through ISO 17025, demanded the application of ISO analytical standards.
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A Review: Fiber Reinforced Polymer Composite Helical Springs

NanotechnologyAbstractIntroductionIn order to successfully reduce the weight of a helical spring it is possible to optimize the material parameters or to use alternative advanced materials instead of conventional engineering ones. Springs are used for vibration damping in mechanical systems and are generally made of steel. As an alternative to material of steel springs in the scope of the study, mechanical behaviors of fiber reinforced polymer (FRP) composite helical springs have been investigated. The FRP composite material has made it possible to reduce the weight of helical spring without any reduction on load carrying capacity. Due to increasing competition and innovation in recent decades, vehicle industries show interest in replacing conventional steel spring with FRP composite helical spring which has advantages such as higher strength to weight ratio, higher stiffness, high impact energy absorption and lesser stresses. The study gives the brief look on the suitability of FRP composite helical springs on related mechanical systems. The objective of the present work is evaluation of the design, analysis and fabrication of FRP composite helical springs.
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Selected Compounds Modulate Various Inflammatory Biomarkers in Lipopolysaccharide-Induced Macrophages of PPAR-α Knockout Mice

Inflammation has been implicated in cancer, diabetes and cardiovascular disease. We have recently screened several compounds that modulate inflammatory biomarkers (TNF-α, IL-1β, IL-6, and nitric oxide) in response to a variety of stimuli. Our hypothesis is that compounds with those anti-inflammatory properties will be useful for treatment of diabetes, cardiovascular disease, and other diseases based on inflammation.
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Enzyme Assisted Extraction of Polyphenols from the Old Tea Leaves

Polyphenols are a main antioxidant in the old tea leaves. These bioactive compounds have been linked with a reduced of risk cardiovascular and cancer.
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Uterine Morcellator versus Resectoscopy in the Management of Heavy Menstrual Flow in Reproductive-Age Women

Submucous leiomyoma and endometrial polyps are the most challenging causes of heavy menstrual flow (menorrhagia) accompanied with infertility, and other clinical issues. There are different hysteroscopic modalities for management of heavy menstrual flow caused by submucous myomas and polyps including conventional hysteroscopic resectoscopy and a novel, recent uterine hysteroscopic morcellator.
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Synthesis and Characterization of Magnetite-Pectin-Alginate Hybrid Bionanocomposite

It is a one pot synthesis of hybrid bionanocomposite comprising of inorganic magnetite with stabiliser biopolymer pectin and alginate in co-precipitation method using sodium hydroxide and ammonium hydroxide as precipitating agents.
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Diagnostic Approaches towards Camelpox Disease

Camelpox is routinely diagnosed based on clinical signs, pathological findings and cellular and molecular assays.
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A One-Year Hospital Based Prospective Study of Sickle Cell Disease from One Capital Area of Kuwait by HPLC

Haemoglobinopathies are inherited disorders of haemoglobin synthesis that are responsible for significant morbidity and mortality all over the world.
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Association between Insertion/Deletion Polymorphism of ApoB Gene with Dyslipidemia and Obesity Risk in Patients with Type 2 Diabetes

Several studies have suggested that Insertion/Deletion polymorphism of ApoB gene is associated with obesity, dyslipidemia, diabetes and coronary heart disease (CHD).
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An Introduction to the Approaches of Novel Drug Delivery Systems for Acquired Immune Deficiency Syndrome (AIDS)

The currently available anti HIV agents have several drawbacks such as short half life, low bioavailability, poor CNS penetration and retention, hepatic first pass metabolism, undesirable side effects and frequent dosing regimen.
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Responses and Survival under Pegylated Interferon α2a Treatment for Patients with Post-MPN Acute Myeloid Leukemia and Acute Panmyelosis with Myelofibrosis

We report here for the first time the efficacy of pegylated interferon α2a (Peg-Ifn) as a therapy for patients with myelofibrosis and high blast counts. We treated four patients who were in an accelerated phase of myeloproliferative neoplasms or acute panmyelosis with myelofibrosis using only this drug.
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A Non-Contact Passive Approach for the Effective Collection of Target Explosive Volatiles for Canine Training Aid Development

The use of real explosive materials for canine training involves inherent dangers, toxicity risks exposure, and often limited availability of the training material all of which may affect the reliable training of canine teams. For this reason, the development of a training aid suitable for daily operations is beneficial to provide safe and effective explosive detection training that can provide for enhanced detection capabilities.
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Electronic-nose Applications in Forensic Science and for Analysis of Volatile Biomarkers in the Human Breath

The application of electronic-nose (E-nose) technologies in forensic science is a recent new development following a long history of progress in the development of diverse applications in the related biomedical and pharmaceutical fields. Data from forensic analyses must satisfy the needs and requirements of both the scientific and legal communities. The type of data collected from electronic-nose devices provides a means of identifying specific types of information about the chemical nature of evidentiary objects and samples under investigation using aroma signature profiles of complex gaseous mixtures containing volatile organic compounds (VOCs) released from manufactured products and parts of the human body. E-nose analyses also provide useful qualitative information about the physicochemical characteristics and metabolic conditions of human subjects without the need for time-consuming analyses to identify all chemical components in human-derived volatile mixtures.
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Characteristic Human Scent Compounds Trapped on Natural and Synthetic Fabrics as analyzed by SPME-GC/MS

The collection of human odor volatiles is of interest to forensic applications as a path to investigate canine scent discriminations in legal investigations. A study using a selected array of previously identified human odor compounds has been conducted to determine the retention and release capabilities of five (5) natural and synthetic fabric types, cotton (mercerized fabric and gauze matrix), polyester, rayon and wool.
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Editorial Board Members Related to poly

Kell Mortensen

Professor
Niels Bohr Institute
University of Copenhagen
Denmark

Kamyar Shameli

Senior Lecturer
Department of Environmental Engineering & Green Technology
Malaysia-Japan International Institute of Technology
Malaysia

Mohsen Meydani

Professor
Friedman School of Nutrition Science and Policy
Tufts University
United States

ALAA EL-DEEN BAKRY YASSIN

Associate Professor
Department of Pharmaceutical Sciences
King Saud bin Abdulaziz University for Health Sciences
Saudi Arabia

Ashik Hayat

Nephrologist
Department of Medicine and Nephrology
Taranaki Base Hospital
New Zealand

Scott Asbill

Professor
Department of pharmaceutics
Presbyterian College School of Pharmacy
United States

GIOVANNI D. DE PALMA

Professor
Department of surgery
University of Naples Federico II
Italy

Francesco Passamonti

Professor of Hematology
University Hospital Ospedale di Circolo
Fondazione Macchi, Varese
Italy

MICHAEL P. SHERMAN

Professor Emeritus
Department of Child Health
Division of Neonatology
University of California-Davis School of Medicine
United States

Mo SONG

Professor
Department of Materials
Loughborough University
United Kingdom
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