Articles Related to safety

Gestational diabetes mellitus (GDM) is associated with an increased maternal and fetal risk of complications. Other than lifestyle modifications and diet, little prevention can be done towards this maternal complication. Through a preclinical approach and a retrospective clinical trial, we investigated the effects of maternal supplementation with a nutraceutical composition based on resveratrol (RSV) and alpha-lipoic acid (ALA) on insulin resistance and GDM status

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Sugarcane is a vital cash crop grown in about 200 tropical and sub-tropical countries around the world. Due to its high rates of occupational diseases, accidents, and fatalities the agro industry is regarded as one of the most hazardous industries despite being one of the essential sectors globally regarding food supply and workforce. Most of the world's cane sugar crop is produced In Low- and Middle-Income Countries (LMIC), such as Sudan, where agriculture and farming are still the main sources of income and managing occupational health and safety is challenging

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That unemployment, poverty, artisanal mining, and community vulnerability are interwoven is re-emphasizing the reality of life. This study assesses the effect of artisanal mining activities on River Kpapi and the adjoining settlements in Minna putting into consideration Sustainable Development Goal 8 (SDG8). Observatory field survey was carried out on the entire river channel, and laboratory analysis of water samples taking to determine its hydro-chemical and Water Quality Index (WQI) characteristics using the silver nitrate method of the American Public Health Association (APHA) and the Water Quality Index (WQI)

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There are no guidelines for pharmacological treatment of COVID-19 disease, but several drugs are being tested every day in search of an optimal therapeutic strategy. The drugs that have been tested, so far, include some antiviral drugs such as danoprevir, favipiravir, darunavir, nelfinavir, remdesivir, umifenovir and the combination lopinavir/ritonavir. Others are drugs targeting inflammatory mediators such as meplazumab, siltuximab, tocilizumab, azithromycin and corticosteroids. Also included in this array of tested drugs are those with pleiotropic actions against SARS-CoV-2 infection like chloroquine/hydroxychloroquine, ivermectin and nitazoxanide, postulated as inhibitors of several phases of virus life cycle. Upon diagnosis of SARS-CoV-2 infection, it is pertinent to embark on a treatment approach based on potential antiviral options, adequately managed under proper medical situation. We suggest that, in addition to the antiviral option efforts, drugs targeting inflammatory mediators should be considered.

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WLAN (wireless local area network) is used as an important worldwide communication-technique. By this, always there is an electromagnetic field exposure. In contrast to the ICNIRP-safety guidelines, whereby no bioeffect is possible by these low-energetic electromagnetic fields, we found artificial signals in the nervous system in dependence on WLAN- exposure.

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Patient safety has become a priority issue in health policy and healthcare management around the world. Assessing physician’s attitudes about issues relevant to patient safety is the first stage of developing a safety culture. This study aimed to measure patient safety culture among physicians in Abderrahman Mami hospital, Ariana, Tunisia.

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The aim of this study was to assess the potential acute adverse effects associated with the use of anti-glaucoma medications among glaucoma patients with Glucose-6-Phosphate Dehydrogenase deficiency.

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We aimed to assess the level of knowledge regarding food additives among medical and engineering students.This cross-sectional descriptive study included students from Inonu University Medicine and Engineering Faculty. The sample size was calculated considering the prevalence rate of food additive knowledge as 22.3%, with a 95% confidence interval, 80% power and 918 individuals. A questionnaire was used to collect the socio-demographic characteristics of the students and their knowledge regarding food additives. Scores for knowledge regarding food additives were created; eight questions were posed to the students, and each known correct answer was given a score of 1. Pearson’s chi-square test, Mann–Whitney U test and Kruskal–Wallis test were used for data analysis.Mean age of the students was 21.74 ± 2.56 years, and 51.7% of them were males. Knowledge level regarding the definition of food additives was not different between genders (p > 0.05). Medical students had significantly higher knowledge levels (92.2%) about the definition of food additives compared to those of engineering students (80.4%) (p < 0.05). More males (52.8%) than females (49.3%) and more medical students (51.6%) than engineering students (50.7%) stated a significantly higher rate of daily consumption of processed foods containing additives (p < 0.05). The median scores of knowledge regarding food additives were not significantly different between gender and faculty (p > 0.05).The present study demonstrated that the rate of the participants who knew the definition of food additives as well as those who perceived food additives to be unsafe were high. Although the knowledge levels on FAs of the students were high in general, it was observed that the frequency of food consumed daily was high This suggests that further research and effective interventions are required to ensure that knowledge turns into behaviour.

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The microbiological purity of the finished products based on bio-activated seed and grain requires special attention, as the level of moisture in bio-activated raw materials is 42-44%, which is a pleasant environment for the development of microorganisms. Therefore, the search for effective ways to increase the microbiological safety of sprouted raw materials and finished products on their basis is always actual.

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Packaging material should meet many requirements for safe preservation of food and extend shelf life. Utilization of nanoparticles to prepare active packaging films has been widely investigated. This review deals with food packaging films modified with nano titania to enhance mechanical, barrier and antibacterial properties of the packages.

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The therapeutic failure rate of eradication therapy for Helicobacter pylori (Hp) is increasing due to bacterial resistance; tobacco smoking can increase such a rate even more. We explored the role of adding moxifloxacin to the standard sequential eradication therapy for Hp in decreasing the therapeutic failure rate among the tobacco smokers.

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We identified 8 eligible trials that enrolled 1392 infants. There was significant effect of prophylactic fluconazole on fungal colonization (RR, 0.31, 95%C1:-0.24 to 0.41; P<0.00001). Effect of prophylactic fluconazole on IFI in VLBW infants: RR: 0.42(95%CI 0.23 to 0.76; P=0.004.). However, prophylactic fluconazole did not reduce mortality in VLBW infants (RR 0.76, 95% CI 0.58 to 1.01; P = 0.06). Studies did not report significant adverse reactions.

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The present study evaluated the efficacy and safety of biosimilar infliximab in patients with active rheumatoid arthritis on a stable dose of methotrexate. Subjects were assigned randomly to either study infliximab or reference infliximab product in an approved dose of 3 mg/kg as an intravenous infusion at week 0, followed by similar doses at Weeks 2, 6 and 14. Primary efficacy endpoint was the proportion of subjects achieving ACR20 criteria at week 16 and secondary efficacy assessment included proportion of subjects achieving ACR20, ACR50 and ACR70 at week 16. In the open-label phase, all responders were followed till week 54. The non-responders entered a follow-up phase for immunogenicity and safety for an additional 3 months.

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Despite several studies having highlighted that candidaemia and invasive fungal disease (IFD) are associated with high mortality and increased costs, there are currently few published studies which provide an insight into real-life practice of invasive candidal diseases. In a medium-sized district general hospital in the UK we sought to compare the efficacy, safety and treatment cost of micafungin versus caspofungin and low dose of liposomal amphotericin B (L-AmB) 1mg/kg/day for the treatment of confirmed candidaemia or clinically diagnosed invasive fungal disease (CDIFD). In the present retrospective audit, a total of 126 patients with candidaemia or CDIFD were reviewed from hospital records and 94 were included in our audit.

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The quadrivalent virus-like particle vaccine against human papillomavirus (QHPV) is a population vaccine targeting peri-pubertal girls and boys. Focus on evaluation of adolescent ovarian safety arises from cases in primary care and published case series describing the development of menstrual dysfunction and idiopathic premature ovarian insufficiency (POI) following QHPV vaccination. A structured review of QHPV vaccine safety studies was performed to answer the question ‘has the ongoing ovarian safety of this vaccine in adolescents been assessed?’ The design, size, and process of pre-licensing safety trials in relation to their capacity to assess ovarian function were reviewed.

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