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Articles Related to toxic

Impaired Driving Associated with the Synthetic Cannabinoid 5F-ADB

Synthetic marijuana compounds are more potent than ∆9-tetrahydrocannabinol (∆9-THC) and are known to produce a wide variety of clinical symptoms including cardiac toxicity, seizures, and death. Erratic driving by a 45 y/o male was witnessed in the fall of 2017 and roadside evaluation of the driver by the responding law enforcement officer concluded that the driver was intoxicated. Comprehensive analysis of the cigarettes by gas chromatography-mass spectrometry detected the synthetic cannabinoid 5-fluoro-ADB (5F-ADB or 5F-MDMB-PINACA). Validated forensic liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods were used to detect the 5-fluoro ADB metabolite 7 (26.37 ng/mL) in the driver’s blood sample. No other drugs were detected. This case report is one of the first to conclusively show that designer synthetic cannabinoids, commonly referred to as “K2” and “Spice”, can significantly impair driving at relatively low concentrations.
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The Roles of IL-33 and TGF-Β1 in the Pathogenesis of Stevens-Johnson Syndrome/ Toxic Epidermal Necrolysis: Potential Biomarkers for Disease Severity

MicroscopyStevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a disease continuum of potentially life threatening, severe allergic drug reactions which result in cellular apoptosis in the skin, mucous membranes, and ocular surface. The exact pathophysiologic mechanisms leading to this apoptosis is unclear but genetic predisposition and abnormal immune regulations play a role.
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Cisplatin-Gemcitabine Related Cardiomyopathy in Non-Small Cell Lung Cancer NSCLC Patient: A Case Study

Gemcitabine is a pyrimidine analog and cisplatin is a platinum agent, they are usually combined to form a chemotherapeutic doublet used to treat different types of oncological cancers, including non-small cell lung cancer (NSCLC). Although these agents are not known to cause such events, few cases related to possible cardiotoxicity side effects have been reported ; including angina, chronic heart failure, arrhythmias, and cardiac ischemia. A 52-year-old African male presented with Stage IV lung adenocarcinoma metastatic to the bone, pleura and lymph node, EGFR wild type. Patient has a history of hypertension, diabetes, and atrial fibrillation and on rate control medications. He was treated initially with cisplatin-gemcitabine, after which he developed cardiomyopathy.
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Biological Effect Tetra-Branched Anti-TNF-Peptide and Coating Ratio-Dependent Penetration of the Peptide-Conjugated Cerium3/4+ Cation-Stabilized Gamma-Maghemite Nanoparticles into Rat Inner Ear after Transtympanic Injection Visualized By MRI

Jing.Zou@staff.uta.fi
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Ventricular Arrhythmia Due to Yellow Phosphorus Poisoning

Ratol paste (Yellow Phosphorus) is a local and systemic toxin affecting almost all the organs of the body especially liver, kidney, brain and heart. There is no specific antidote for yellow phosphorus poisoning. Heart is one of the many organs affected by the YP. However cardiac toxicity following acute ingestion of YP has been reported rarely.
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Fatal road accidents in Spain: psychoactive substances in killed drivers in 2014

Road traffic accidents (RTAs) are often related to impairment by alcohol or drugs. The objectives of this study is to present toxicological data on drivers killed in traffic accidents in Spain in 2014 from a sample of 614 drivers and 240 (out of 614) with positive results for alcohol, illicit drugs and psychoactive medicinal drugs.
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Treosulfan Plus Fludarabine – Encouraging Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation in Multiple Myeloma

Allogeneic transplantation (Allo-SCT) in multiple myeloma is controversial mainly due to the relatively high non-relapse mortality (NRM). The aim with this retrospective single-center study was to evaluate recent transplants particularly after conditioning with treosulfan plus fludarabine (TreoFlu).
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A Non-Contact Passive Approach for the Effective Collection of Target Explosive Volatiles for Canine Training Aid Development

The use of real explosive materials for canine training involves inherent dangers, toxicity risks exposure, and often limited availability of the training material all of which may affect the reliable training of canine teams. For this reason, the development of a training aid suitable for daily operations is beneficial to provide safe and effective explosive detection training that can provide for enhanced detection capabilities.
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A Review on Nanoprobes for Sensing, Imaging and Disease Detection

This review focuses on imaging, visualization and detection of diseases using nanoprobes. Several currently available nanoprobes such as fluorescent nanoprobes, upconversion nanoparticle probes, supermagnetic iron oxide nanoprobes, and polymer- and liposome based nanoprobes are discussed.
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The Vicky Calder Case: A Review

Vicky Calder stood trial twice for the attempted murder of her ex-de facto partner, David Lloyd, by means of deliberate poisoning with acrylamide. Lloyd was left blind, paralysed from the neck down and was unable to speak without mechanical assistance after he fell into a coma following a mysterious ailment.
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Histological and Immunohistochemical Study on the Toxic Effects of Anthracene on the lung and liver of Adult Male Albino Rats and the Possible Protective Role of Ocimum gratissimum Extract

Anthracene is the simplest tricyclic aromatic hydrocarbon. It has been identified in surface and drinking water, ambient air; exhaust emissions, smoke of cigarettes and cigars and in smoked foods and edible aquatic organisms. It is primarily used as an intermediate in the production of dyes.
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Lead (Pb) Toxicity Trigger Schizophrenia in Battery Workers of North Region of India

Total production of Pb acid batteries in India is about 8 million per year and nearly 10,000 Kg of Pb is consumed in the production of batteries.
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Melatonin Effectively Preserves Cognitive Function in Club Drug Intoxicated Rats

Excessive exposure to club drug gamma-hydroxybutyric acid (GHB) would cause cognitive dysfunction in which impaired Ca2+-mediated neuroplasticity in hippocampus may play an essential role in the pathogenesis of this deficiency. Considering melatonin is positive for neuroplastic regulation, the present study aims to determine whether melatonin would exert a neuro-protective effect on cognitive function following GHB.
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Stability Analysis of Human Islet Amyloid Polypeptide and Its Mutated Oligomeric Forms

Human islet amyloid polypeptide (hIAPP), a 37 residue peptide hormone is an ingenious factor in pancreatic amyloid deposits found in cases with type-2 diabetes. Its aggregation into small toxic oligomeric species is presumed to be the reason for cells debilitation and demise in case of diabetic patients.
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Warfarin-Induced Tissue Necrosis (WITN): Case Report and Literature Review, A Proposed Name Change

Warfarin is the most frequently prescribed oral anticoagulant in the United States. Its indications range from treatment of deep venous thrombosis and pulmonary emboli to the prophylaxis and treatment of thromboembolic conditions associated with atrial fibrillation and cardiac valve replacement. While bleeding is the most commonly encountered complication warfarin induced skin necrosis (WISN) can be a rare complication. Extensive skin and deeper tissue necrosis may be encountered requiring multiple surgical debridement and reconstructive procedures along with the medical management.
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Editorial Board Members Related to toxic

HENGYI XU

Associate Professor
State Key Laboratory of Food Science and Technology
Nanchang University
China

Ramesh C. Gupta

Professor of Chemistry
School of Agricultural Sciences and Rural Development (SASRD)
Nagaland University
India

Trevor Archer

Department of Psychology
Uppsala University
Sweden

Ana Rita Ramalho Figueiras

Faculty of Pharmacy
University of Coimbra
Portugal

Mariusz Cycon

Department of Microbiology and Virology
School of Pharmacy with the Division of Laboratory Medicine
Medical University of Silesia
Poland

DUARTE NUNO VIEIRA

Professor
Portuguese National Institute of Legal Medicine and Forensic Sciences
University of Coimbra
Portugal

Osman Erkmen

Professor
Department of Food Engineering
University of Gaziantep
Turkey

Anuradha Ratna

Department of Medicine
University of Massachusetts Medical School
USA

Magdy Kharoshah

Forensic Medicine Authority
Ministry of Justice
Egypt

Desheng Pei

Professor
Chongqing Institute of Green and Intelligent Technology
Chinese Academy of Sciences
China
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