Recent Articles

Large numbers of nations are associated with utilization of anti-toxins regardless of remedy (OTC medications). This DDD/ ATC value contributes to improved antibiotic use quality. The principal objective is to direct improvement of sane medication use of strategies and to give a standard technique for information for future evaluation.

Occasional constipation is associated with infrequent bowel movement and difficulty in passing stools without any obvious symptoms. Ginger has been used traditionally to manage various gastric conditions like constipation, dyspepsia, belching, bloating, epigastric discomfort, indigestion, nausea, and vomiting. The current study evaluated the effects of a standardized Ginger extract (GE) on objective and subjective markers of occasional constipation in a randomized, double-blind, parallel, placebo-controlled design

: Obesity is a global epidemic with serious consequences for countries. Objective: This work aims to systematically review the available evidence on the relationship between basal metabolism (BM), body composition, and physical activity (PA) with central obesity. Methodology: The search strategy was carried out using Web of Science, PubMed, Google Scholar, and SciELO following the PRISMA guidelines. The STROBE checklist and the Jadad scale were also used for quality assessment.

In literature are reported various use of activated charcoal AC and derivates in biopharmaceutical purifications.Aim of this work is to verify impurity proficle when using this technology.Various commercial products are reported here but it is not the scope of this work put in relation with any toxicological reaction: only to describe the technique used in this field.Because various drugs and bioproduct need purification steps it is if of interest to see some material science peculiarity

Nanocrystal technology has showed significant potential for commercial applications and advancements as a novel pharmacological method to increasing the water solubility of certain poorly soluble medicines. Nanotechnology is the most effective method for solving the solubility issues with medications in BCS classes II and IV. This article is primarily concerned with the methods of preparing nanocrystals by means of Precipitation Lyophilization Homogenization (PLH) Technology. In particular, emphasised combinative technology could improve particle size reduction. Technology, equipment, and medication physicochemical qualities affect particle size reduction success

Allergic bronchopulmonary aspergillosis (ABPA) is an idiopathic inflammatory disease of the lung, characterized by an allergic inflammatory response to colonization of the airways by Aspergillus fumigatus or other fungi. Untreated or inadequatetreatment may lead to poor outcome in patients. Raised level of serum IgE of more than 1000 IU/ML have been considered as one if theimportant diagnostic criteria for ABPA, however relation of serum IgE withs severity ofdiseases is lacking. This study was conducted to find out level of serum IgE in patients ofABPA and to find out corelation of Serum IgE with duration of symptoms and diseasesseverity.

This study was conducted to compare the bioavailability of two tablet formulations containing 200 mg Lacosamide (one Lacosamide 200 mg film-coated tablet marketed in Italy as Ollat®, one Vimpat® coated tablet). 20 healthy subjects were enrolled in a single-center, randomized, single-dose, laboratory-blinded, 2-period, 2-sequence, crossover study, with a minimum washout period of 7 days. All the 20 subjects completed the study. Plasma samples were collected up to 72.0 hours post-dosing. Lacosamide levels were determined using a validated high-performance liquid chromatography with tandem mass spectrometry (HPLC/MS/MS) method

Pneumonia is most prevalent and acute respiratory disorder. Chest radiography is the gold standard to confirm the clinical condition and the progress. The use of AI in diagnostic workflow proved to be useful. In this study, quantitative assessment by the AI device is compared with the qualitative assessment by the radiologists.

Dental dyschromias have several origins among them we cite fluorosis. Dental fluorosis is defined as a qualitative anomaly of the enamel, resulting histologically in hypomineralisation due to excessive ingestion of fluorides during amelogenesis. Clinically, it takes the form of opacities in the enamel. These opacities may affect homologous teeth symmetrically, and generally affect several groups of teeth. Topographically, isolated or confluent white lines or discrete white patches are observed. Interpretismatic spaces are wider, resulting in porous and permeable enamel. On the one hand, this explains the post-eruptive dyschromias, where exogenous pigments penetrate the pores and transform the white opacities into brown. It is classified into 3 categories: mild, moderate and severe. So that this case was moderate fluorosis and appropriated for the treatment with enamel microabrasion. Differential diagnosis for this condition includes: enamel hypoplasia, amoelogenesis imperfecta, and dental caries.

Respiratory Syncytial Virus is an etiological cause of lower respiratory tract infections. Due to the controversial therapeutic approach, it has a significant share in the causes of hospitalizations and even fatal outcomes concerning children up to two years of age. The elderly patients, especially the immune compromised and those with co-morbidities, are at a great risk of developing severe conditions because it is often not considered as pathogen. Those are the reasons which determine the necessity of prophylaxis of the abovementioned target groups of patients - children up to two years of age and adults over 65 years of age.

The transdermal drug delivery system is technique that provides drug through the intact skin. Skin penetration enhancement techniques have been developed to increase the bioavailability of drug substance. These review describes various transdermal patches available in market, types of patches, basic components, polymer used in formulation. The novel drug delivery method do well and complete with those already on the market the main problem that requires consideration include device design and safety, efficacy, ease of handling and economical. Transdermal drug delivery system represent the most attractive method among these because of its low rejection rate, magnificent, ease of administration and better convenience and compliance with patient. This review article provide an overview of transdermal drug delivery system contains various innovative dosage forms. In comparison transdermal patch are effective due to its easy to apply and non-invasive.

Using longitudinal data that tracks bulimic behavior among young girls (National Heart, Lung, and Blood Institute Growth and Health Study), we examine (1) whether the persistence in bulimia nervosa (BN) can be attributed to slow learning about the deleterious health effects of BN or if it reflects tolerance formed from an addiction; and 2) whether bulimic behavior is consistent with addiction criteria as stated in the Diagnostic and Statistical Manual of Mental Disorders DSM-IV. To address the endogeneity of past behavior, we use instrumental variables, and show that past BN positively and significantly impacts current BN after controlling for individual heterogeneity. When accounting for BN ”stock,” the parameter estimates of past behavior are not negative, which casts doubt on the importance of learning. Making the case for treating BN as an addiction has important policy implications. First, it suggests that the timing of educational policy and treatment is crucial: preventive educational programs aimed at instructing girls about the deleterious health effects of BN, as well as treatment interventions, will be most effective if provided in the early stages. Second, it would put those exhibiting BN on more equal footing (from a treatment reimbursement perspective) with individuals with drug or alcohol addictions.

Stress of the endoplasmic reticulum (ER) is induced by the accumulation of misfolded proteins in this organelle. It can be triggered by biotic and abiotic stress (particularly heat), but also by chemical treatments (such as DTT and tunicamycin) at a laboratory scale. To respond to this stress, various cellular mechanisms are involved, including the highly conserved protein repair pathway, the UPR (Unfolded Protein Response). This pathway aims to restore protein homeostasis in cells. In cereals, seed storage proteins (SSP) represent one of the characteristics that determine grain quality and are of great interest to agriculture. Unlike dicots, the dynamics of the UPR induction pathway in monocots are poorly documented in the literature.

Background: Despite their good efficacy, antiretroviral drugs often induce adverse effects, in particular hypersensitivity reactions (HSR) which cause significant discomfort leading to the abandonment of treatment and then to therapeutic failure in some HIV-positive patients. Therefore, in this study, we aimed to assess the association between immune responses and hypersensitivity reactions (HSR) induced by antiretroviral treatment in people who living with HIV-1 (PLHIV-1), through the distribution of immune cells and cytokine profiles.

Despite Taiwan’s title as one of the most efficient recycling systems, individual recycling habits contribute to these efficient recycling systems. Despite Taiwan’s successful strategy of demolishing waste through incineration, improper recycling at a grassroots level, such as students’ municipal solid waste recycling habits, result in recycling contamination, and improper waste recycling could lead to the release of toxic fumes into the atmosphere. This study compares the recycling practices and recycle bin setups of a public school and a private international school to determine important factors that could contribute to decreasing waste recycled improperly. The results show that immediate feedback if a student recycled improperly as well as clear recycling signs were essential factors to decrease recycling mistakes.

Supraventricular tachycardia is the most common type of tachyarrhythmia seen in childhood. First-line treatments (adenosine, esmolol-propranolol, digoxin, electrical cardioversion) usually suppress tachycardia, but rarely tachycardia is resistant and requiring Class IC and/or Class III agents, such as amiodarone, sotalol, propafenone, and flecainide.

Introduction: Tanzania aims for 95% of persons living with HIV (PLHIV) to know their serostatus by 2023. Methods: An uncontrolled before-after study design was conducted between March 2018 (pre-intervention phase) and July 2018 (post-intervention phase). A total of 183 participants (males=89; females=94) were recruited for this study. Data were collected at baseline and at the one-month and three-month follow-ups using a pre-and post-test semi-structured questionnaire. Descriptive data are presented using measures of central tendency and their respective measures of dispersion. No comparative statistical analysis was performed.

Among surgical cases of bronchoplasty with complete pulmonary preservation, those that require anastomosis of three stomas are rare. Usually, a double-barrel type reconstruction is performed by suturing two distal bronchi together and then anastomosing them to the proximal bronchus. However, the procedure is technically difficult because of the difference between the stomal diameter of the proximal bronchus and that of the two distal bronchi, and the tension at the anastomosis site is imbalanced. Herein, we present a rare surgical case of a bronchoplasty with complete pulmonary preservation in whom we performed an anastomosis between three stomas using a modified Montage-type technique. The advantage of this technique is that it allows free trimming of the anastomosed side-to-side stoma before anastomosis with the third bronchus, thus decreasing the tension at the anastomosis site and improving the outcome. We believe, this technique is superior to the other known techniques.

Pathologists are frequently involved in the diagnosis of sarcoidosis on conventional biopsies and cytology specimens. Histology generally does not pose difficult tasks in the correct clinical and imaging scenario, but atypical forms of sarcoidosis exist, and in these cases, the diagnosis may become difficult. The final diagnosis always requires the careful integration of the histology with the clinical, laboratory, and radiologic findings. The differential diagnoses of sarcoidosis includes granulomatous infections, hypersensitivity pneumonitis, pneumoconiosis, autoimmune diseases, drug reactions, chronic aspiration, and even diffuse fibrosing diseases. In this study, we discuss the histomorphological aspects of Sarcoidosis, along with radiological, biochemical and clinical aspects. The most important finding is the presence of non caseating granulomas by histology which needs to be interpreted in the light of appropriate clinico-radiological and laboratory findings. This study emphasises the role of the pathologist and discusses the differential diagnosis.