Recent Articles

Human female- derived osteoblast- like cells in culture (hObs) and the cell lines (SaOS2 and hFOB) express mRNAs involved in bone biology and physiology such as estrogen receptor α (ERα) and α (ERα), vitamin D receptor (VDR), 1α, 25 (OH) vitamin D3 hydroxylase (1OHase) and 12 and 15 lipoxygenases (12LO and 15LO). These mRNAs are modulated by estrogenic compounds. Since the skeletal protective effects of estrogens are not discernible in diabetic women, we tested the estrogenic modulations of these parameters in cells grown in growth medium containing high glucose (HG; 9.0g/L; 44mM) compared to normal glucose (NG; 4.5g/L; 22mM). HG significantly increased DNA synthesis (DNA) and creatine kinase specific activity (CK). Stimulations of DNA but not of CK by estradiol-17β (E2), by 4, 4’, 4’’-[4-propyl-(1H)-pyrazol-1, 3, 5- triyl] tris-phenol (PPT; ERa specific agonist), or by 2, 3-bis (4-hydroxyphenyl)-propionitrile (DPN; ER β specific agonist), were modulated by HG. HG Itself up regulated the expression of mRNA of 12LO and 15LO and to less extent ERβ and VDR, but had no effect on ERα and 1OHase mRNA expression. The different hormonal treatments modulated the expressions of VDR, 1OHase, 12LO and 15LO mRNAs which were reduced in HG, whereas the induction of their products 1α, 25 dihydroxy-vitamin D3 (1,25D) and 12- and 15- hydroxyeicosatetraenoic acid (12 and 15 HETE) were only slightly affected by HG. The exact mechanism of HG effects on bone cell responses and its relationship to human bone physiology is not yet clear.

The mental health as field of action for the physiotherapists is an important challenge that implies formation and investigation. The alterations of the mental health on a global scale are nowadays a problem of public health that it makes necessary that the professionals of the area of the health have a deeper knowledge on the topic to act of way adapted from the prevention and intervention.

Autism Spectrum Disorders (ASD) is regular heterogeneous neurodevelopmental disorder with symptoms like disability in social association, repetitive behavior interest and activities. Etiology of autism and different speculations of ASD were proposed keeping in mind the end goal to clarify the pathophysiology of ASD.

Late recourse to nephrology consultation remains a topical issue which concerns both developed and developing countries such that a majority of the patients are seen to be at an advanced stage of chronic kidney diseases. The aim of this study is to assess the clinical and paraclinical profile of patients referred for primary nephrological consultation.

In his Phenomenology of Spirit, Georg Hegel suggests that to be moral is to act in accordance with the moral tradition of one’s own country. 1 Hence, for Hegel, individuals act morally to the extent that they bear witness to the traditional moral climate in which they are situated. Thus understood, acting morally is a social phenomenon, comprised of attitudinal ebbs and flows that are nuanced by the changing moral traditions with which they inextricably interrelate. This much has proven particularly true with regard to the evolution of western attitudes toward death and [1,2] dying. 2 Indeed, significant traditional changes from the Middle Ages to the present day have transformed the hidden perceptions of death and dying (“thanatological apprehension”) of history into the increasingly rapid and perceptible expressions of [3] today.3

microRNAs play critical roles in cancer metabolisms. miRNA-181a-5p is significantly down-regulated in non-small lung cancer tissue and mesenchymal like lung cancer cells. Epithelial-mesenchymal transition mechanisms and cancer metabolism are controlled by the same signaling pathway.

Administration of exogenous progesterone or progestin can suppress estrous behavior in mares. Compounded long-acting formulations of progesterone are widely available. The objective of this study was to determine if a long-acting injectable progesterone formulation would suppress behavioral estrus in mares. Five mares were monitored daily by rectal palpation and transrectal ultrasonography to insure that all mares were cycling normally. Endogenous progesterone was removed through lysis of the corpus luteum seven days post-ovulation with prostaglandin F2 alpha (PGF2α). Two days following PGF2α administration, mares received 2 g of long-acting progesterone intramuscularly. Estrous behavior was determined daily by individually exposing mares to a stallion beginning two days before injection of long-acting progesterone until ovulation occurred. Serum progesterone concentrations were significantly elevated (>2 ng/mL) for 10 days following treatment with a long-acting injectable progesterone. Behavioral estrus suppression during this period was minimal and not significant. All mares developed local injection site reactions and half the mares developed febrile responses following treatment. In conclusion, the long-acting compounded formulation of progesterone elevates progesterone concentrations for 10 days but does not suppress estrous behavior to a stallion. Due to the side effects associated with this treatment, long-acting formulations of injectable progesterone are not appropriate for use in performance horses.

Phenylbutazone (PBZ) is commonly used in equine patients for treatment of orthopedic injuries. Phenylbutazone may adversely affect bone healing because of suppression of prostaglandin production. We hypothesized that administration of the prostaglandin analog misoprostol would enhance bone healing and mitigate the untoward effects of PBZ on bone response to injury in horses. The objectives of this study were to determine whether the administration of misoprostol would enhance bone healing and whether concurrent administration of PBZ and misoprostol would mitigate the untoward effects of phenylbutazone. Twenty horses were randomly assigned to one of four groups (n=5 per group): Group 1 (untreated control), Group 2 (phenylbutazone alone), Group 3 (misoprostol, alone), or Group 4 (concurrent treatment with phenylbutazone and misoprostol). A 4.5-mm diameter uni-cortical bone defect was created in one metacarpal III bone of all horses. Fluorochromic bone labels were administered intravenously on Days 0, 7, and 14. Computed tomographic osteoabsorptiometry and histomorphometric analyses were performed on the harvested metacarpal bones. Phenylbutazone treatment caused a decrease in endosteal new bone formation. Administration of misoprostol appeared to mitigate the magnitude of the PBZ effect on new bone formation (endosteal in-growth, p

One of the tropical fruits with high economic value is pineapple. Smooth cayenne (smooth leaf) and Red Spanish (Rough leaf) are the two cultivars of pineapple grown in the world. They grow in the soil and resemble epiphytes in that their roots are intolerant of poor soil aeration.

Bats (order Chiroptera) are one of the diverse mammal groups and distinguishing from other mammals by their real flight. Bats have long been postulated to play essential roles in agriculture including arthropod suppression, seed dispersal, pollination, biological indicator, organic fertilizer provider (guano) and improving soil structure, etc.

Ticodendron incognitum the only species of the Ticodendraceae family was discovered in Costa Rica in 1989 and currently there are no reports on its chemical composition or biological activity.

The use of organic fertilizer as an alternative to inorganic fertilizer increased among subsistence farmers in rural areas in meremieti. Despite the fact that, no clear recommendation exist for the application of rate of organic fertilizer on vegetable. Field experiment was conducted to evaluate the different combination of organic and inorganic fertilizer on yield and yield component of cabbage.

Part of the study was to assess the concentration of secondary metabolic (total: phenolic, flavonoid, and proanthocyanidin, tannin) and the antioxidant activities in methanol (MeOH) and methanol-water (MeOH-H2O) extract of GnA.

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune inflammatory disease. Several indexes can measure SLE activity, and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) is one of them. The aim was to associate SLEDAI with inflammatory biomarkers present in serum (C3, C4, CH50, C-reactive protein, and creatinine), proteinuria (urine 24h) and urine NGAL in SLE patients. This study included 43 SLE patients who were arranged in two groups according to the value of SLEDAI. One group, SLEDAI 0-4 (n=25), included SLE patients with low activity, and the other group, SLEDAI >4 (n=18), included SLE patients form moderate to high activity. Level of urine NGAL (uNGAL) was determined by ELISA, and the data were analyzed using GraphPad Prism 5.

Aeric syndrome during a multiple trauma reflects the severity of this latter, which made mention to extra thoracic or intra thoracic lesion. This requires a good diagnostic and therapeutic strategy. We report the case of a young patient admitted to emergency in an array of closed multiple traumas where the etiological diagnosis was rare and unknown. This case highlights that a careful questioning and a good examination in admission can reveal earlier the diagnosis, the thing that was not well led in our case, because the patient was mute, anxious, and not cooperating making unnoticed rape history.

Obesity is a contemporary phenomenon that consumes an enormous and substantial public expense regarding health for needy countries. The amount spent only for the cost with the treatment of obesity for the SUS (The Unified Health System) was estimated around half a billion of reais in 2011 (Oliveira, 2013) [1]. In this scenery, the purpose towards prevention and control initiatives concerning these outlines must really become fundamental. This study has aimed to analyze the efficacy developed by a multidisciplinary team during a period of 12 months (from 2016 to 2017). The intervention has consisted in a number of periodic consultations supervised by this special team within food directions and physical training. All the data were synthesized and analyzed statistically through the Mcneunann Test, regarding the significance degree of p< 0.05. It has been observed in such results that most of the participants belong to feminine sex having from 45 to 81 years of age, a low schooling and a short monthly income. For the present, what must be said is that the intervention was wholly effective providing reduction of corporal measures, improvement in the quality of the diet consumed, besides a strengthening in the social network, empowering for the participants, further the expansion of knowledge about topics relative to food and nutrition. So, it can finally be suggested that initiatives towards obesity control are indeed effective and important and must be promoted everywhere.

Significant work has been attempted to better comprehend the attributes and mechanisms suggested in simulation and data mining in precedent research. More prominent understanding causes not only give progresses in numerous fields but also enable experts to better consider the last target.

The identification of altered splicing signatures in Myelodysplastic Syndromes (MDS) could likely provide key markers for diagnosis, prognostication and development of novel therapeutics. This review presents an insight into role of spliceosomal gene mutations in the pathogenesis of MDS, emphasizing on their clinical and prognostic significance. We also discuss emerging studies delineating the functional consequences of these mutations and pointing towards the emergence of a new leukemogenic pathway involving spliceosomal dysfunction.

To evaluate the quality of life and the impairment of the emotional function of women with breast cancer under chemotherapeutic treatment, in relation to sociodemographic and clinical characteristics. Observational, longitudinal, and analytical research; conducted between 2013 to 2015 with 67 women in three stages of chemotherapy treatment in a public referral teaching hospital in Paraná. Two questionnaires, one for socio-demographic and clinical data, and the Quality of Life Questionnaire-C30 were used for data collection.