Recent Articles

Schistosomiasis is one of the most widespread parasitic diseases in the world. Spinal Cord Schistosomiasis (SCS) usually presents acutely or subacutely and classified into three clinical forms: medullary, myelo-radicular and conus-cauda equina syndrome. Despite the fact that Kuwait is not an endemic country for Schistosomiasis, many expats residing in this country are from endemic areas. We report a case of a 29 years old Egyptian male with conus-cauda equine syndrome with classic radiological findings and good response to treatment.

The discovery of antibiotics was one of the greatest achievements of medical science. The introduction of these drugs into medical practice has saved and continues to save millions of lives. At the same time, every year it becomes more and more obvious that antibiotics are not a universal remedy for inflammatory diseases, and their long-term use entails the emergence of new problems

The de-extinction of the dinosaur is a dubious possibility but its consideration brings forth some issues that are at least worthy of scientific discussion. In this review, we discuss two distinct issues that have implications for a de-extinct species such as a dinosaur: the ability, or lack thereof, to safely sedate a rare and potentially fractious animal capable of harming the veterinary staff tasked with its care; and, disease risks associated with a species that has been extinct for millions of years. To identify potential sedatives, comparative pharmacology will be needed to uncover the links between receptor pharmacology and the desired clinical outcomes of activating established alpha-2 adrenergic, opioid, and benzodiazepine receptors. Specific to disease control, it will be necessary to understand the unique susceptibility of the new species to current diseases as well as predicting their reservoir capacity for potential human and veterinary pandemic diseases. While the topics presented herein are not exhaustive, this review highlights some of the foremost research that should be conducted in order to serve the unique veterinary needs of a de-extinct species using the dinosaur as a paradigm. Addressing these issues should be considered if an intact dinosaur genome becomes available, regardless of the feasibility of dinosaur resurrection.

Sickle cell disease is a prevalent and severe monogenic disorder resulting from a homozygous missense mutation in the β-globin gene that leads to polymerization of hemoglobin S. Clinical manifestations of the disease can be critical with considerable morbidity and mortality. One treatment option for the disease is bone marrow transplantation. However this method is restricted to the patients with an appropriately matched donor. Gene therapy by either gene insertion or gene editing, utilizing patient’s own cell is a primary therapeutic option to cure sickle cell disease. However, very less clinical trials have been performed with genetic therapy for treating Sickle cell disease (SCD). Since a couple of decades significant progress has been made in the area of gene therapy for treating monogenic hemoglobin disorders. Numerous therapies are currently in clinical trial stages or in preclinical stages. The safety and efficacy of gene therapy has been greatly improved with the initial use of γ-retrovirus vectors, followed by next-generation lentivirus vectors, and latest gene editing techniques. Although the clinical interpretation of gene therapy has been successful, it involves some limitations including complex cellular abnormalities, inadequate transgene expression, and challenges in achieving effective and persistent inhibition of polymerization of hemoglobin S. This review intends to discuss gene therapy strategies specific to Sickle cell disease, present state of the field, and current status of the gene therapy clinical trials.

Statement of the Problem: Euthanasia is a desire to ease the suffering of the patient suffering from pain due to terminal illness and incurable. On the one hand, opponents of euthanasia argue that the value of the sanctity of life is a supreme value, which is also anchored in the basic law in Israel.

Over the years, all parts of a commercial refrigerator, such as the compressor, heat exchangers, refrigerant, and packaging, have been improved considerably due to the extensive research and development efforts carried out by academia and industry.

Despite the growing HIV burden, the disease continues to receive a relatively high public health priority in the Republic of Congo. To establish the knowledge, attitude, and practice on HIV/AIDS among general practitioners working in Brazzaville and to register their actual behavior in the prevention of HIV/AIDS. The study was a descriptive cross-sectional study. The sample size was 35 General Practitioners. A self- administered questionnaire was used to collect data in a four-week period in August 2017. Selected at random, were asked to participate. The data collected was analyzed using the Statistical Program for EpiInfo.

Although there are many researches on drug of abuse behavior using C. elegans as model organism, the precise targets and mechanism shared by C. elegans accompanied with behavioral responses to substance misuse is still scarce. This alternative model for rodents and other animal organism has been used to investigate genetic mechanism and specific genes coding drug-induced behavioral response. However, there is very few papers reported to summarize and analyze findings from original researches to identify target/genes underpinning responses to drug addiction.

The pathogenity of S. aureus strains are related with features like its adherence, various toxins, enzymes, structural and extracellular factors. In our study, the relationship between biofilm formation and lipase, protease, urease activity were investigated in S. aureus strains isolated from various clinical specimens sent to our microbiology laboratory.

Hepatitis E virus (HEV) is a single stranded, positive RNA virus belonging to the Hepeviridae family. HEV infection can cause an acute hepatitis that is self-limited. However, fulminant hepatic failure can occur in patients with underlying chronic liver disease, in the elderly, and in pregnant women. Genotypes 3 and 4 (HEV-3 and HEV-4) are present in humans and other animals, and are the main cause of autochthonous cases of hepatitis E in industrialized countries.

Good quality ribonucleic acid (RNA) needs to be obtained in order to study gene expression. Different RNA extraction methods have been described, but RNA quality and yield may vary among the different techniques and biological study species. To date, there is no standardized method for extraction and purification of RNA from Candida genus yeasts.

In this paper, the discussion will be on the physical quantities of generalized thermoelastic medium with double porosity under Lord and Shulman theory. The effect of rotation and gravity has been established. The half-space is considered of an isotropic homogeneous thermoelastic material.

This paper presents the development and implementation of a Biometric Based Door Lock System that will automatically unlock a door when a registered fingerprint is sensed. The method employed in accomplishing this involves the use of a fingerprint scannerR305 interfaced with ATMEGA 328 Arduino microcontroller to actuate the locking and unlocking process of a door.

In this study, low cost spatial and temporal in-situ measurement and water quality parameters of Marmaris bay are collected thought the coastal. The bathymetry of the Marmaris bay is mapped according to depth sonar measurement.

Nocardiosis is an acute, subacute, or chronic bacterial infection that is typically acquired through inhalation and usually presents with pulmonary, central nervous system, and cutaneous manifestations. In critically ill patients, Nocardiosis has an unusually high morbidity and mortality.

The aim of this study is to determine the physico-chemical properties, pasting profiles and sensory scores of complementary food from co-processed maize and carrot. TZE-YPOP-DT-STR-QPM and normal maize; SUWAN-ISR were selected for this study. Each variety was divided into two portions; a portion was co-milled with 20% carrot while the other portion was co-fermented with 20% carrot.

The focus of this research is aimed specifically at the application of near-infrared spectroscopy (NIRS) in exercise and sport science. NIRS is able to monitor the performance of muscle and cerebral tissue and evaluate their role during physical activity. By monitoring tissue oxygenation, an NIRS device is useful in several areas, which may benefit from its applications.

Low back pain is a global health issue, potentially affecting the individual’s functionality in daily life. Teaching is regarded as a human service occupation and in recent years it is been identified as a highly stressful occupation.

The experiment was conducted to investigate the effect of induced hyperlipidemia in SD rats fed with high fat diet (HFD) for 7 weeks on blood lipid profile and possible pathological changes in liver, stomach, intestine, heart, spleen, lung and kidney. There were significant differences in most rats which induced hyperlipidemia throughout the experimental period with the blood lipid levels and histopathology.

Ethiopian agriculture is dominated by smallholder farmers with an average per capita land holding of less than a hectare in which the production system mainly depends on rain fed. In order to characterize the climate of Mieso, Melkassa, and Adami Tulu located in Central rift valley (CRV) of Ethiopia.