Recent Articles

Only 10% of people diagnosed with multiple myeloma are under 50, and 2% of people are under the age of 40. Here we pre sent the case of a 24-year-old female admitted to the hospital for recurrent genital infections, severe anemia and a normal phosphocalcique balance. The myelogram studies revealed normochromic normocytic non-regenerative anemia, as well as a 12% marrow infiltration by abnormal plasma cells. Immunological analysis by immunofixation revealed a homogeneous band in the gamma-globulin zone. After the 5th chemotherapy cycle, the 6-month follow-up assessment showed complete remission.

Introduction: Erythrocyte fetomaternal incompatibility is defined by the binding of erythrocyte alloantibodies of a pregnant woman to fetal antigens, inherited from the father. Alloantibodies are produced by the immune system after prior contact with these same antigens during transfusion, transplant or previous pregnancy.

Introduction: in childhood and adolescence, behaviors are acquired that can influence the rest of to human being's life. At this age, eating habits can well shaped, with to view you reducing childhood obesity, which has increased every year in Brazil and around the world. During the school period, students consume foods that directly influence their weight and depending on their socioeconomic level, choices can well significant in the quality of consumption.

physiological changes during pregnancy modulate the endocrine system. This study was carried out with the aim of establishing thyroid specific reference range and prevalence of thyroid dysfunction in pregnant women in their first semester in mild- to moderate iodine deficient area.

Cereal crops like rice provides food and sustain health in animal consumers. Its edible caryopsis besides being a source of energy also act as the main nutritional foundation especially for mankind. This paper reviewed the structural complexity of caryopsis, distribution pattern of various nutrients present and their medicinal properties

The fashion to consume fast food among pre university students is growing at a faster rate. They are also being consumed because of their taste and high calories, although they lack essential nutrients. The present study was done to assess the knowledge of health and environment of fast food consumption among Under Graduate College students.

Background: The solitary median maxillary central incisor is a rare anomaly associated with numerous craniofacial and oral developmental disorders, such as a single central incisor located in the midline of the maxilla and abnormalities such as facial dysmorphia and congenital stenosis. Objective: To present a clinical case report of an infant patient with solitary median maxillary central incisor who underwent surgery to correct pyriform aperture stenosis and subsequent rapid maxillary expansion using a microimplant-assisted Journal of Paediatrics and Neonatal Disorders 2 Annex Publishers | www.annexpublishers.com Volume 8 | Issue 1 rapid palatal expander. Results: The early diagnosis and interventions performed on the patient allowed an increase in nasal airflow with a positive response in the rehabilitation of respiratory and swallowing functionality. Conclusion: The microimplant-assisted rapid palatal expander device use in an infant proved to be a safe and effective procedure.

There is growing evidence suggesting a correlation between multiple copies of transcription factor-3 (TCF3) and various malignancies, yet its impact on patients with breast cancer remains uncertain. The present study utilized the Cancer Genome Atlas (TCGA) database, Gene Expression Omnibus (GEO) database, and the UALCAN database to obtain expression profiles and clinical data from patients with breast cancer. A comparative analysis was performed to assess the differential expression levels of TCF3 in breast cancer tissues as compared to normal breast tissues. TCF3 was found to be overexpressed in breast cancer and exhibited significant associations with T stage, age, race, PAM50 subtype, histological type, ER, PR and menopause status. Subsequently, analyses were performed to determine functional enrichment. The enriched pathways encompassed xenobiotic metabolism by cytochrome P450, chemical carcinogenesis-DNA adducts, extracellular matrix organization, cornified envelope formation, collagen biosynthesis and modifying enzymes, as well as immunoregulatory interactions between lymphoid and non-lymphoid cells. Single-sample gene set enrichment analysis (GSEA) was utilized to evaluate the infiltration of immune cells. The methylation status of TCF3 was analyzed using the UALCAN and MethSurv databases. The overexpression of TCF3 is a significant contributor to decreased disease-specific survival (DSS) and progression-free interval (PFI). Likewise, the low methylation status of TCF3 is also associated with an adverse prognosis. Finally, the differential expression of TCF3 between tumor and normal tissues was validated using data from multiple sources, including GSE22820 dataset, 49 pairs of tumor and paracancerous samples sequencing data, and CPTAC dataset. Moreover, proteomic analysis of the CPTAC dataset showed that TCF3 expression was associated with alterations of multiple tumor-related pathways. Therefore, TCF3 may serve as a new tumor-related biomarker.

Domestic violence, traditionally perceived as a female-centred issue, significantly impacts male victims as well, yet remains underreported and under-researched. Domestic violence against men is a widely neglected problem with few studies ex amining its prevalence and effects on married men of different populations.

We tend to picture a pharmacy as familiar aisles and a waiting prescription counter. But for my generation of aspiring health care professionals, that image is shifting long before that. The future of medicine, particularly in critical areas like specialty pharmacy, is emerging as a dynamic, tech-intensive health innovation hub. Specialty pharmacy tackles complex treatments for cancer, multiple sclerosis, rare diseases and many others, and is poised for a major change

There is growing evidence suggesting a correlation between multiple copies of transcription factor-3 (TCF3) and various malignancies, yet its impact on patients with breast cancer remains uncertain. The present study utilized the Cancer Genome Atlas (TCGA) database, Gene Expression Omnibus (GEO) database, and the UALCAN database to obtain expression profiles and clinical data from patients with breast cancer. A comparative analysis was performed to assess the differential expression levels of TCF3 in breast cancer tissues as compared to normal breast tissues. TCF3 was found to be overexpressed in breast cancer and exhibited significant associations with T stage, age, race, PAM50 subtype, histological type, ER, PR and menopause status. Subsequently, analyses were performed to determine functional enrichment. The enriched pathways encompassed xenobiotic metabolism by cytochrome P450, chemical carcinogenesis-DNA adducts, extracellular matrix organization, cornified envelope formation, collagen biosynthesis and modifying enzymes, as well as immunoregulatory interactions between lymphoid and non-lymphoid cells. Single-sample gene set enrichment analysis (GSEA) was utilized to evaluate the infiltration of immune cells. The methylation status of TCF3 was analyzed using the UALCAN and MethSurv databases. The overexpression of TCF3 is a significant contributor to decreased disease-specific survival (DSS) and progression-free interval (PFI). Likewise, the low methylation status of TCF3 is also associated with an adverse prognosis. Finally, the differential expression of TCF3 between tumor and normal tissues was validated using data from multiple sources, including GSE22820 dataset, 49 pairs of tumor and paracancerous samples sequencing data, and CPTAC dataset. Moreover, proteomic analysis of the CPTAC dataset showed that TCF3 expression was associated with alterations of multiple tumor-related pathways. Therefore, TCF3 may serve as a new tumor-related biomarker.

Puerperal infection is a public health threat which may lead to maternal death and poor neonatal outcomes. Chlorhexidine is a representative antiseptic that is effective against the bacteria colonized in the reproductive tract of women. But researcher’s attitude towards the antimicrobial effects of chlorhexidine on pregnant women are conflicting. We sought to evaluate the preventive effect of chlorhexidine on puerperal infection and neonatal outcomes.

Ovarian cancer is responsible from more than 150.000 death annually worldwide. This cancer is detected in the late stage, and is characterised with poor prognosis, therefore most cases result with death. The diagnosis and the treatment of the disease have to be improved for a better quality of life for patients. MicroRNAs are the noncoding RNAs in the length of 19-24 nucleotides which show suppressor effect on target genes. miRNAs are included in the pathology of various diseases including cancer. miRNAs being as the biomarker candidates in diagnosis, and their use in treatment as the inhibitors of the molecules mimicking the miRNA showed that they may be used as the new therapeutic target and agents. We detected with our group in our prior study conducted with disconcordant ovarian cancer twins that many miRNA molecules were different in ovarian cancer compared with the molecules in healthy sibling. The expression level of miR-142-3p that was selected from the miRNAs detected in the previous study was compared, and investigated in a wider ovarian cancer group, and in healthy control group. miR-142-3p expression level was investigated using the real-time PCR method in the present study involving 147 patients, and 100 healthy control group. The differences in the expression levels of miR-142-3p detected in the peripheral blood lymphocytes of ovarian cancer patients, and healthy control were statisticaly evaluated. The expression level of miR-142-3p was detected to have increased 3.11 fold in ovarian cancer patients compared with the levels in healthy controls, and the difference was statistically significant (p:0.00). These results suggest that miR-142-3p that was found significantly increased in the peripheral blood samples of ovarian cancer patients compared with the healthy controls might be used as a sensitive, noninvasive biomarker in the early diagnosis, and treatment and follow up of ovarian cancer.

Ovarian cancer is responsible from more than 150.000 death annually worldwide. This cancer is detected in the late stage, and is characterised with poor prognosis, therefore most cases result with death. The diagnosis and the treatment of the disease have to be improved for a better quality of life for patients. MicroRNAs are the noncoding RNAs in the length of 19-24 nucleotides which show suppressor effect on target genes. miRNAs are included in the pathology of various diseases including cancer. miRNAs being as the biomarker candidates in diagnosis, and their use in treatment as the inhibitors of the molecules mimicking the miRNA showed that they may be used as the new therapeutic target and agents. We detected with our group in our prior study conducted with disconcordant ovarian cancer twins that many miRNA molecules were different in ovarian cancer compared with the molecules in healthy sibling. The expression level of miR-142-3p that was selected from the miRNAs detected in the previous study was compared, and investigated in a wider ovarian cancer group, and in healthy control group. miR-142-3p expression level was investigated using the real-time PCR method in the present study involving 147 patients, and 100 healthy control group. The differences in the expression levels of miR-142-3p detected in the peripheral blood lymphocytes of ovarian cancer patients, and healthy control were statisticaly evaluated. The expression level of miR-142-3p was detected to have increased 3.11 fold in ovarian cancer patients compared with the levels in healthy controls, and the difference was statistically significant (p:0.00). These results suggest that miR-142-3p that was found significantly increased in the peripheral blood samples of ovarian cancer patients compared with the healthy controls might be used as a sensitive, noninvasive biomarker in the early diagnosis, and treatment and follow up of ovarian cancer.

Ovarian cancer is responsible from more than 150.000 death annually worldwide. This cancer is detected in the late stage, and is characterised with poor prognosis, therefore most cases result with death. The diagnosis and the treatment of the disease have to be improved for a better quality of life for patients. MicroRNAs are the noncoding RNAs in the length of 19-24 nucleotides which show suppressor effect on target genes. miRNAs are included in the pathology of various diseases including cancer. miRNAs being as the biomarker candidates in diagnosis, and their use in treatment as the inhibitors of the molecules mimicking the miRNA showed that they may be used as the new therapeutic target and agents. We detected with our group in our prior study conducted with disconcordant ovarian cancer twins that many miRNA molecules were different in ovarian cancer compared with the molecules in healthy sibling. The expression level of miR-142-3p that was selected from the miRNAs detected in the previous study was compared, and investigated in a wider ovarian cancer group, and in healthy control group. miR-142-3p expression level was investigated using the real-time PCR method in the present study involving 147 patients, and 100 healthy control group. The differences in the expression levels of miR-142-3p detected in the peripheral blood lymphocytes of ovarian cancer patients, and healthy control were statisticaly evaluated. The expression level of miR-142-3p was detected to have increased 3.11 fold in ovarian cancer patients compared with the levels in healthy controls, and the difference was statistically significant (p:0.00). These results suggest that miR-142-3p that was found significantly increased in the peripheral blood samples of ovarian cancer patients compared with the healthy controls might be used as a sensitive, noninvasive biomarker in the early diagnosis, and treatment and follow up of ovarian cancer.

Coronary stent fracture is a rare complication of stent implantation. The reported incidence of stent fracture among present drug-eluting stents from various studies ranges from 1% to 8%. Coronary stent dislodgement and embolization is also a rare complication in the current era of percutaneous coronary angioplasties

Tuboculosis is an infectious disease commonly in China especially in immunodeficiency patients. But multiple sites tuberculosis infection stays rare. We let's report A rare case: pulmonary tuberculosis with skeletal and lymphatic tuberculosis and successfully treated.

Solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms, with pancreatic involvement being exceptionally uncommon. This case corresponds to a 67-year-old woman who consulted for pancreatic mass causing biliary obstruction and imaging studies suggested pancreatic adenocarcinoma or a neuroendocrine tumor. Histopathological analysis of a biopsy identified spindle-cell proliferation without atypia or necrosis and a characteristic

Background: Traditional neuron models rely on the all-or-none principle of action potentials, often overlooking the grad ed, energy-dependent dynamics that underlie real neural behavior. This limited view may contribute to our difficulty in un derstanding complex neurodegenerative disorders.

Guillian Barre Syndrome (GBS) is the most common cause of minor flaccid paralysis in the world and post-polio eradica tion is the most common cause on the Indian subcontinent as well. It affects 0.6-4 people per 1 lakh people per year. Guil lian-Barre syndrome should be distinguished by a variation associated with inflammation of the cortical area of brain of chronic inflammatory polyneuropathy predicting prognosis and clinical course. Children have a better prognosis than adults and usually recover after a different period. However, in the Pressing event of the disease, the damage can be severe and can lead to long-term residual disability which can hamper quality of life especially in young population.in such sce narios ,use of early rehabilitation may prove to be of good effect. This article gives an effective overview of the effect of the physical therapy in improving quality of life.:The objective of This article was to perform a summary of the currentKnowl edge-base on outcome and its determinants in using early rehabilitation programme as a part of GBS management.