Recent Articles

Solution blow spinning (SBS) o ers an easily adaptable alternative that has the potential to generate on-demand conformal nano ber mats directly on a wide range of targets. e present study demonstrates the facile fabrication of polycaprolactone (PCL)-gelatin nano bers using only a commercial airbrush and compressed gas. e PCL content increased mechanical strength, and gelatin content enhanced cell adhesion, proliferation, and acceleration of the biodegradation rate. An animal study was then used to demonstrate some of the possible surgical applications, including use as a surgical hemostatic, as a surgical sealant, and in tissue reconstruction

Inflammation arises through a complex network of dozens of molecules (including interleukin, interferon, chemo-kine, tumor necrosis factors, and acute-phase proteins) and many cell types (including monocytes, granulocytes, mast cells, and lymphocytes) [1-3]. Among the numerous cytokines involved in inflammation, the interleukin 1 (IL-1) family is involved in almost all types of inflammation and is an important inflammatory therapeutic target [1,2,4]. Interleukin 1 (IL-1) family members are central mediators of innate immunity and inflammation. In systemic or local pathological conditions such as tissue injury [5-7]

Laboratory studies of the patient suggested the existence of measles virus infection after the measles vaccination, EBV infection, combined with its iron protein, abnormal level of lipid, and hemophagocytes in the bone marrow smear indicated that the patient caught a EBV related hemophagocytic lymphohistiocytosis syndrome co-infected with measles.

Twelve patients with complex pelvic acetabular fractures were randomly divided into 3D group and conventional group, 6 cases in each group. Before operation, all patients completed routine examinations such as whole blood analysis, coagulation analysis, electrolyte of liver and kidney function, blood glucose, complete set before blood transfusion, urine analysis, electrocardiogram, color

The infection of Human Papillomavirus has remained the major health problem globally, with striking disparities between low-, middle-, and high-income countries in rates of infection, the attendant viral disease impacts, and access to preventive measures. This systematic review has looked into key health indicators in terms of prevalence and incidence of infection, the burden of cervical cancer, vaccination coverage, and screening programs across these economic categories in light of human papillomavirus infection

Immunosenescence describes the decrease in immune function with advancing age, a phenomenon that is associated with changes in the B and T lymphocyte populations. CD8+ T cells display the most dramatic phenotypical and functional changes within the T cell compartment whereby the cohorts of effector and memory T cells expand while the total population and diversity of naive T cells both decline.

Background and objectives: The early differentiation between infectious and non-infectious sepsis remains a challenge due to the lack of a reliable, ready available and quick biomarker of bacterial sepsis. This study aims to determine the diagnostic accuracies of procalcitonin (PCT), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) as individual and combined predictors of bacterial sepsis, when compared to the gold standard microbiological cultures

Background: This study aimed to elucidate the relationship between fast foods and snack consumption with the health-relat ed quality of life (HRQoL) among overweight and obese children of ‘My Body is Fit and Fabulous’ at school (MyBFF@s chool) intervention program.

Background: Obesity induces insulin resistance, increases serum free fatty acids (FFAs), and causes renal problems includ ing albuminuria. Adipocyte insulin resistance has an important effect on occurrence of whole-body insulin resistance, which is correlated with fasting free fatty acids and fasting insulin levels. Bariatric surgery (BS) improves albuminuria, free fatty acid and insulin levels. We investigated whether albuminuria associates with adipocyte insulin resistance and whether following BS a reduction in albuminuria relates to the improvement of adipocyte insulin resistance.

Irrigation is a pivotal phase in the correct performance of an endodontic treatment, because it represents an essential support for mechanical instrumentation. The removal of the smear layer occurs through the combined use of instrumentation protocols and an appropriate irrigation methodology. Unfortunately, despite effective instrumentation, some areas such as septa, isthmuses and lateral canals are not easily reachable by irrigating solutions, and consequently bacterial contamination in these areas remains a constant concern. To address this challenge, we considered using a gel composed of hyaluronic acid (generically referred to together with its salts as HAS), nano-micro-structured silicon dioxide (SiO2 ) and antimicrobial agents. Hyaluronic acid gives the gel optimal viscosity, reducing the iatrogenic effects of endodontic treatment and promoting tissue repair processes, even inside the microtubules after sealing the root canal.The presence of nano-micro-structured silicon dioxide offers numerous advantages, including the slow release of disinfectant agents, a cleansing action and physical lubrication with micro-abrasion during the opening and reaming phases of the root canal. The combined effect of hyaluronic acid and silicon dioxide ensures excellent adhesion of the gel to the instruments, significantly improving the performance of endodontic treatment.

he term MINOCA denotes all those cases of myocardial infarction with an angiographic immagine of epicardial coronary arteries free of angiographically significant lesions. To date, the percentage of MINOCA in the AMI population is estimated to be between 3% and 15% (1). This subclass was introduced in 2018 by the European Society of Cardiology with diagnostic criteria based on the fourth universal definition of AMI.1

This article addresses the inefficiencies of the current healthcare credentialing process that contribute to workforce shortages by proposing a blockchainbased system. Leveraging blockchains unique features, the proposed system aims to reduce time, cost, and labor, off¬ering significant time savings

The average annual incidence of inhospital cardiac arrest (IHCA) in Europe ranges from 1.5 to 2.8 per 1000 hospital admissions [1]. Individual countryspecific studies reported rates of 1.6 in the United Kingdom [2], 1.7 in Sweden [3], 1.5 in Italy (Piedmont region) [4], and 2.8 in Poland [5]

Background and Objective: Septic shock remains an impatient cause of morbidity and mortality. Early restitution of the circulation improve tissue oxygen delivery and increase survival. This study is a prospective randomized single center study its main objective is to investigate the therapeutic value of hypertonic saline in patients with septic shock. Methods: Fifty-two critically ill patients admitted with septic shock divided into two groups, the first group received isotonic saline (control group) starch, while the second received hypertonic saline 5%. Results: The mean central venous pressure in the first and third hours of the intervention in the isotonic saline group was significantly higher than the hypertonic saline group. (Respectively, P=0.024 and P=0.014). The average pH and BE in the second and third hours of the intervention in the isotonic saline group were significantly higher than the hypertonic saline group. (Respectively, P=0.032 and P=0.040). The average bicarbonate in the third hour of the intervention in the isotonic saline group was significantly higher than the saline group. (P=0.008). Also, the average optic nerve diameter in the third hour of the intervention was 4.4±0.1 in the isotonic saline group and 4.2±0.2 in the hypertonic saline group, and there was a significant difference between the two groups in this hour. Conclusion: Our study results showed that hypertonic saline administration in septic shock patients is safe and can be used as an adjuvant resuscitation fluid therapy as i it has a preventive ability in causing tissue edema compared to isotonic crystalloid solutions.

Introduction: Hemorrhagic cerebrovascular accident (HCVA) is a medical or medico- surgical emergency requiring treatment in neurovascular or intensive care units. The aim of this work was to determine the prognostic factors of hemorrhagic stroke in young subjects in intensive care in the 3 university hospitals of Abidjan. Methods: This is a descriptive and analytical retrospective study covering, which extends from January 2018 to December 2022, taking into account. All patients aged 18 to 50 admitted to intensive care for a hemorrhagic stroke during the study period. Results: 146 patients including 100 men were included. The average age was 43 years old. High blood pressure was the main modifiable risk factor. The average Glasgow score was 8.2 and 98% of cases presented with impaired consciousness. Grade 3 hypertension was found in 73 patients on admission. The main location of the hemorrhage on imaging was parenchymal and 45% of subjects had an ICH score greater than or equal to 3 in almost 50% of cases. Nicardipine was the antihypertensive of choice. 103 patients were intubated and ventilated. 52% underwent neurosedation 13% underwent neurosurgery. The average length of hospitalization was 8.3 days during which 72.6% of patients presented complications, mostly infectious. Mortality remains high at 66.44% of cases. We listed as prognostic factors, inaugural deep coma, inaugural grade 3 arterial hypertension, ICH severity score greater than or equal to 3, renal failure and length of stay less than 7 days. Conclusion: Hemorrhagic strokes in young subjects remain a common condition in our country. Mortality in intensive care is high and is linked to clinical and neurological severity, biological disorders, the occurrence of complications and the length of stay in intensive care

Background: Blood is a specialized connective tissue with a complete and unchangeable identity. It provides one of the means of communication between cells of different parts of the body and the external environment. In modern medicine, blood transfusion is an important procedure to replace blood loss. At least 30 common antigens and hundreds of other rare antigens have been found in human blood cells and shown to be linked to anemia and other diseases.

Background: First-line treatment of primary central nervous system lymphoma (PCNSL) includes high-dose methotrex ate-based polychemotherapy (HD-MTX). Nevertheless, HD-MTX is associated with renal toxicity, potentially compromis ing chemotherapy completion and prognosis. Our objective was to identify early predictive factors of HD-MTX delayed elimination.

Classical Hodgkin's lymphoma (cHL) is a common neoplasm in persons living with the human immunodeficiency virus (HIV).

Thalassemia was not uncommon in north of China. Patient Concerns: The clinical data of 21 northern birthplace thalassemia patients were collected. Diagnosis: They were di agnosed as carrier thalassemia.

Although ibrutinib has shown significant therapeutic advantages in the front-line treatment of chronic lymphocytic leukaemia compared to current chemotherapy drugs, the fundamental question of whether ibrutinib improves anticancer ef ficacy and tolerability in patients with untreated or relapsed/refractory NHL, especially for specific histological subtypes, re mains unanswered