Recent Articles

Globally, primary liver cancer ranks sixth in terms of morbidity among all cancer types, and it is the second most common tumor of the digestive tract. Furthermore, it is responsible for the fourth highest number of cancer-related deaths [1]. Among the various histological types of primary liver cancer, hepatocellular carcinoma (HCC) exhibits the highest incidence rate

This study aims to identify the risk factors for axillary lymph node metastasis (ALNM) and establish a novel nomogram for predicting the possibility of an ALNM model based on clinicopathological and characteristics of tumor location. A three-dimensional(3D) model was also established to accurately describe the location of tumors prone to axillary lymph node metastasis.

Hepatocellular carcinoma (HCC) is a common malignant tumor, and hepatitis B virus (HBV) is the main pathogenic factor. The occurrence of HBV-associated hepatocellular carcinoma (HBV-HCC) is a complex process caused by multi-gene and multi-step interactions. The synergistic effect of multiple cancer-promoting mechanisms accelerates the evolution of the disease from inflammation to tumorigenesis

Gastric cancer is a malignant tumor originating from gastric mucosal epithelium. And more than 90% of them are gastric adenomas. At present, surgical treatment is the main method to cure gastric cancer. We found that many genes may play a role in the occurrence and cell transformation of malignant in gastric cancer, including APOA2

Thyroid cancer (TC) is one of the most prevalent endocrine malignancies with an increasing incidence worldwide. Though therapeutic effect is relatively good in the vast majority of TC patients, the anaplastic thyroid cancer (ATC) remains one of the most malignant tumors. This study aimed to investigate the role of SETDB2, an epigenetic regulator, in the dedifferentiation of TC cells

Oral submucous fibrosis is a potentially invasive condition which leads to lockjaw and inability to eat. The pervasiveness rate oforal submucous fibrosis in India is 0.2-2.3% in males and 1.2-4.6% in females [II. Timely diagnosis and appropriate treatment is necessary to cease the advancement. A case oforal submucous fibrosis occurring in 38year old male patient is presented in this paper. The patient was advocated on the ill-effects of areca nut and chances of malignant transformation and treatment was given for the same.

Foreign body ingestion is a common occurrence among children and adultswith certain risk factorsincluding advanced age and psychiatric diseases. However, in clinical practice we encounter healthy adults who are diagnosed with unintentional foreign body ingestion and are suspicion would help clinicians for prompt diagnosis in such cases.

We present a case of total esophageal reconstruction with a free Jejunal flap in a patient with a history of esophagectomy and two previous failed attempts at reconstruction. Despite the technique here described offers a reliable option when the stomach and colon are not available, the success of the reconstruction might be compromised by the onset of a perforated ulcer at the gastric blind pouch related to previows failed gastric pull-up (GPU) After a major reconstructive surgery of long hours, gastric pouch may develop ulcer with perforation and fatal empyema due to Stress, although the severe complication is rare. Surgeons performing esophageal reconstruction should be aware of the risks related to the presence of the blind pouch, The indications and limits of the reconstructive technique used as well as the rapid development of this unexpected and severe complication are discussed.

Cirrhosis is an end-stage liver disease. Patients with cirrhosis characterized by manifestations of portal hypertension and impairment of liver function. When the natural course of the disease progressed from compensated status to decompensated one, life expectancy of the patients would be shorted obviously. Complications including refractory ascites, spontaneous bacterial peritonitis,variceal bleeding.

lymphoproliferative disorders and opportunistic infections in IBD patients treated with immunomodulators is a concern, EBV status. Combination therapy (thiopurines plus biologics such as anti-Tumour Necrosis Factor (TNF) agents) is perceived to have higher complication rates and there is more concern about the risk of lymphoproliferative disease than for patients on single modality therapy. We present two reports of patients treated with combination therapy for IBD who presented with lymphoma within weeks of each other and review the evidence for the increased risk with this therapy.

HIV/AIDS occupy a special place among other diseases. It is Incurable and frightening disease, causing anger and denial.

Summary: Recent studies suggest a potential relationship between helicobacter pylori (HP) infection and small intestinal bacterial overgrowth (SIBO). The state of the digestive tract microflora is not often taken into account in the treatment of children with chronic gastroduodenal pathology associated with HP. The purpose of this study was to determine the frequency of SIBO in children with duodenal ulcer disease (DUD) and functional dyspepsia associated with HP

Objective and Design: The aim of this project was to evaluate the influence of inflammatory cytokines IL- and IL-8 on gastric •pithelial-mesenchymal transition in gastric epithelial cells.

Spinal muscular atrophy is an autosomal recessive disorder characterized by degeneration of alpha motor in anterior horn cells of brain and spinal cord, which results in muscular atrophy, hypotonia, fasciculations, areexia, paralysis and even death in most severe cases. The underlying cause of this disease is biallelic loss of survival motor neuron 1 (SMN1) gene. Depending upon the clinical features & patient's age, SMA is classied into dierent distinctive sub types.

Escherichia coli is the commonest Bacteria for urinary tract Infection do regulate its transcription predominantly at the stage of initiation by repressors and/or activators.

Out of 31 patients evaluated by serology for Echinococcosis during the study period, 7 (22.58%) were seropositive. Liver was the most frequent site involved (24 patients; 77.77%). Second organ the lung 5(16.13%) bone 1(3.23%) and the optic 1(3.22%). Of the respectively

lesion, known as invasive or aggressive candidiasis, can be extremely refractory to treatment. confused by the fact that the patient was a chain smoker, and also because the initial MRI images were strongly suggestive of an invasive malignancy. When clinical and radiological signs exactly mimic a malignancy, the picture is confusing.

According to UNASID report in 2018 Women continue to account for a disproportionate percentage of new HIV infections among adults (aged 15 and older) in sub-Saharan Africa: they represented 59% of the 980 000 million [820 000–1 100 000] new adult HIV infections in 2017 with available data

The study was approved by the The Medical Ethics Committee of the Cardiovascular Institute and our Hospital. All meth ods were performed in accordance with relevant guidelines and regulations. The written informed consent was obtained from the patients

Abstract coordinates are needed in some applications for polygons with concave vertices. Such elements do not have rational barycentrics and mean-value coordinates (Floater, 2003) [1