Articles Related to Apoptosis

Autophagy is an abnormal physiological process in the body that deals with the destruction of cells in the body as it maintains homeostasis or normal functioning by protein degradation and turnover of the destroyed cell organelles for new cell formation. Non-essential parts like damaged proteins are recycled and invading microorganisms and toxic compounds are removed. As per the physiological process, if the human body does not undertake regular bouts of autophagy, process ends up with dysfunction, metabolically inflexible mitochondria.

View complete article: PDF  |  Full-text

Inhibiting multiple pathways/targets with combination drug therapies is widely used to maximize therapeutic benefit in many diseases. Therapeutic success can often be improved by concurrently and/or sequentially inhibiting multiple pathways/targets by combining drugs with different mechanisms of action.

View complete article: PDF  |  Full-text

Polymorphonuclear (PMN) neutrophil leukocytes are cells of innate immunity recognized in a peripheral blood smear because of their particular multilobed nucleus. Ring shaped nucleous are typical in rats and mice, being described in some pathologies in humans as well as in healthy subjects.

View complete article: PDF  |  Full-text

In relation to assisted mammalian reproduction, the goal of cryopreservation is to preserve without significant loss of viability a stock of gametes and/or embryos with a view to thawing those cells for use in in vitro reproduction treatments. There are numerous cryopreservation protocols, which vary in terms of cryoprotectant used, storage temperature, freezing and thawing rates, and the particular cells that they are suitable for preserving.

View complete article: PDF  |  Full-text

Immunohistochemistry (IHC) was used to determine the protein levels of p27, CD117 and ki67 in tumor tissue of xenograft. After treatment of Fan, the morphologic changes were observed by DAPI staining, Hoechst staining and TUNEL detection under fluorescent microscopy.

View complete article: PDF  |  Full-text

A monoclonal antibody (Mab) designated as GHR106 was generated against the extracellular domain (N1-29 synthetic peptide) of human gonadotropin releasing hormone (GnRH) receptor. It is a first-in-class GnRH analog and can serve as a drug candidate for potential applications in the treatment of human cancers and/or fertility regulations.

View complete article: PDF  |  Full-text

Seventeen alpha hydroxyprogesterone caproate (17-OHPC) is the only FDA-approved drug labeled for prevention of preterm delivery. This drug is also available as a compounded product from licensed compounding pharmacies. This article reviews the FDA approval history and pharmacy compounding quality control data of 17-OHPC, as well as briefly discusses possible future pharmaceutical development strategies for 17-OHPC.

View complete article: PDF  |  Full-text

Salmonella is a causative agent for a wide variety of pathological diseases in humans, cattle, poultry and other farm animals and hence Salmonella infections are a major cause of concern to humans, veterinary animals and to food industry.

View complete article: PDF  |  Full-text  | Digital

They are cytokines secreted by adipose tissue considered to be immunomodulating agents, however they can be more accurately put into the larger, growing list of adipose-derived hormones.

View complete article: PDF  |  Full-text  | Digital

Mitogen-Activated Protein Kinase (MAPK) pathway is a signal transduction pathway that functions in a wide range of physiological and pathophysiological cellular events including cell proliferation, differentiation, apoptosis, migration, inflammation, metabolic disorders and diseases.

View complete article: PDF  |  Full-text  | Digital