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Articles Related to HPLC

Separation and Detection of Monocrotophos by Chromatography Methods in Forensic Samples

Monocrotophos is a extremely hazardous organophosphate insecticide that is extensively used and easily accessible in India.
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Determination of N-Butylscopolamine in Human Plasma by Solid-Phase Extraction and UHPLC-ESI-MS/MS: Development, Validation and Application to a Bioequivalence Study

BioequivalenceA sensitive ultra performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS) method for measurements of N-butylscopolamine in plasma was developed and validated. A SPE extraction was proposed for the clean up of plasma and N-butylscopolamine-d9 was added as internal standard. The analyses were carried out using a phenyl column and mobile phase of acetonitrile:
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A Study on Chromatography Methods for the Separation and Detection of Certain Benzodiazepine Drug in Forensic Sample

Forensic Scientists are required to identify an ever increasing and more complex assortment of drugs and related compounds.
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Optimization of Pseudomonas aeruginosa for Chlorpyrifos Degradation using Response Surface Methodology

Chlorpyrifos is a hazardous organophosphate pesticide used worldwide thus its biodegradation is need of the time. In the present study 13 bacterial strains were isolated from collected soil samples of different agro climatic regions and out of them one bacterial strain was screened out as potent degrader of Chlorpyrifos on the basis of percentage degradation using high pressure liquid chromatography (HPLC).
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Novel analytical technologies of Quality in the Sheep & Goat Dairy Sector

France, Greece, Italy, and Spain the major sheep and goat milk producers in Europe, got the initiative through an interim of 30 years (1985 – 2015), to organize - through IDF - 7 symposiums aiming at the upgrade of the Dairy Sector. One major interest was the milk quality. Stepwise, the efforts followed cow milk structural development in organizing the testing laboratory, the definition of quality in composition (fat, protein, lactose, total solids), in Hygienic (Total Bacteria Count, Somatic Cell Count, antibiotics residues and Aflatoxin M1 contamination), adulteration with water and detection of milk species. EU, by Decision 2002/657/EC, defined the rules for the Directive 96/23/EC, enumerated the testing methods, the demands in sampling procedures, the minimum limits of performance, the quality control (ISO 17025) and the interpretation of results. The equivalency of results from different laboratories, through ISO 17025, demanded the application of ISO analytical standards.
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The Impact of Repeated Hb A2 Measurements on β-Thalassemia Trait Diagnosis

Hemoglobin A2 (Hb A2) is a minor component of the hemoglobin present in normal adult red blood cells, accounting for 1.5-3.5% of the total hemoglobin in healthy individuals.
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A One-Year Hospital Based Prospective Study of Sickle Cell Disease from One Capital Area of Kuwait by HPLC

Haemoglobinopathies are inherited disorders of haemoglobin synthesis that are responsible for significant morbidity and mortality all over the world.
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Effects of Age and Sex on Sickle Cell Disease Avascular Necrosis

Sickle cell disease (SCD) is a hemoglobinopathy. Based on genotypes, it is classified into sickle cell thalassemia (SCTh) and sickle cell anemia (SCA).
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Bioequivalence Study of Two Oral-Capsule Formulations of Pregabalin 300 mg in Healthy Mexican Adult Volunteers

Pregabalin is a ligand for the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. It has anticonvulsant, analgesic, and anxiolytic activity. The bioequivalence of a test formulation was evaluated with respect to its corresponding reference drug formulation of oral pregabalin 300 mg, administered as a capsule. This randomized-sequence, single-dose, single-blind, two-period crossover design under fasting conditions was done on 25 healthy Mexican adult subjects including both genders. There was a seven-day washout period.
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Simultaneous HPLC Assay of Paracetamol and Sulfapyridine as Markers for Estimating Gastrointestinal Transit of Amphotericin B-containing Nanoparticles in Rat Plasma

A simple and sensitive two-step reversed-phase HPLC method was developed and validated for determining amphotericin B, paracetamol and sulfapyridine in rat plasma using piroxicam as internal standard.
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A New Bi-Functional Derivative of Polyethylene Glycol as Molecular Carrier for Eugenol and Ibuprofen

Eugenol (EU) and ibuprofene (IBU) were covalently bound to a bi-functionalized PEG, used as molecular carrier of drugs and the release kinetics of the two bioactive molecules was studied in vitro in buffer solution at pH 7.4, in simulated gastric fluid and in mouse plasma.
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Relative Bioavailability of Ciprofloxacin Doses (750 and 1000) mg in Healthy Male Volunteers by Using HPLC Method

A new, stable and accurate high performance liquid chromatography ultraviolet spectrophotometric method for quantitation of Ciprofloxacin in human plasma was developed and validated.
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Reduction of Bitterness and Enhancing Palatability of Cetirizine Oral Liquid Dosage Forms by Cyclodextrins

The aim of this manuscript is to study cyclodextrins (CDs) as a potential excipient to suppress bitterness and enhance palatability of pediatric liquid preparations for Cetirizine, an extremely bitter drug. Natural α, β and γ CDs; and β CD derivatives such as hydroxyl propyl (HP), randomly methylated (RM) and sulfobutyl ether (SBE) β-CDs were screened in different molar ratios of 1:1, 1:2 and 1:3 for their inhibition of the extremely bitter taste of Cetirizine using the human gustatory sensation test.
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Topical Delivery System for Phytochemicals: Capsaicin and Capsicum Tincture

Capsaicin, an active ingredient of Capsicum fruit, is currently undergoing “revival” in the clinical management of pain. However, the choice of its formulation is rather limited to the use of “old-fashioned” tinctures and recently the patches. In an attempt to improve the therapeutic outcome and develop its skin-friendly formulation, we prepared the vesicle-based drug delivery system with capsaicin.
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Quantitative Analysis of 30 Drugs in Whole Blood by SPE and UHPLC-TOFMS

An Ultra-High Pressure Liquid Chromatography Time-of-Flight Mass Spectrometry (UHPLC-TOF-MS) method for quantitative analysis of 30 drugs in whole blood was developed and validated. The method was used for screening and quantification of common drugs and drugs of abuse in whole blood received from autopsy cases and living persons.
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Editorial Board Members Related to HPLC

Syed W. Shah

Associate Professor
School of Health Sciences
Universiti Sains Malaysia
Malaysia

Sayed M. Hassan

Senior Research Scientist
University of Georgia
USA

Kornélia Tekes

Professor
Department of pharmacodynamics
Semmelweis University
Hungary

Loai Aljerf

Professor
Department of Basic Sciences
Faculty of Dental Medicine
Damascus University
Syria

Ahmed S. Zidan

Associate Professor
Department of Pharmaceutics and industrial pharmacy
Zagazig University
Egypt

Olcay Kaplan

Faculty of Engineering
Department of Food Engineering
Munzur University

FRANCISCO FERNANDEZ CAMPOS

Professor Adjuant
Department of Pharmaceutical Technology
University of Barcelona
Spain

Scott Asbill

Professor of Pharmaceutics
College of Pharmacy & Health Sciences
Campbell University
United States
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