Top Links

Articles Related to Molecular

Envisioning Molecular Network of Obesity by Omics Stratification

To date, Obesity is considered prime concern of public health with multi-dimensional factors engaged in metabolic discrepancy that is rooted from multifactorial causes (i.e., environmental intoxication or genetic abnormality), and the unmet landscape of health care system seeks for therapeutic or preventive measures. Compelling evidence support Omics as strategic tool of systemic biology is benefit to define wiring of molecular circuit in metabolic malfunction and evaluation of metabolic modulator such as synthetic drugs, stem cell replacement, and natural secondary metabolites from various resources.
View complete article: PDF  |  Full-text

Neurobiochemical Roles of Low Molecular Weight Antioxidants on Oxidative Stress Biomarkers and Severity of Ischemic Stroke in Wistar Rats

Purpose: To evaluate the neurobiochemical role(s) of low molecular weight (LMWA) antioxidants in the treatment of surgically- induced ischemic stroke (IS) in wistar rats.Methods: Ischemic stroke was induced in wistar rats using middle cerebral artery occlusion (MCAO). Neurological assessments were carried out using stair case, cylinder test and modified neurological severity score (mnss) methods. Low molecular weight antioxidants (vitamins C, E, α-lipoic acid, dimethyl sulfoxide and mannitol) were orally administered to the rats for two weeks in three different doses (22.5, 45 and 67.5 mg/kg).
View complete article: PDF  |  Full-text

Wildlife Forensic: Current Techniques and their limitations

The wildlife includes undomesticated and diverse forms of floral and faunal species, which is essential for ecological balance and human survival. The poaching and illegal trade has resulted in sharp decline of many wild species of flora and fauna around the world. The need of the time therefore is to utterly focus on wildlife protection for the sustainable development of biosphere and future viability of human beings. In this review we have focused on different techniques being utilized in wildlife forensic science for identification of wildlife species as well as their geographical origin. These techniques can be employed to control the wildlife crimes and convict the criminals involved in illegal trade of wildlife flora, fauna and their products. These techniques include footprints analyses, morphological and anatomical studies,
View complete article: PDF  |  Full-text

Structural, Elemental and Molecular Characterization of Normal And Osteoarthritic Human Articular Cartilage

The articular cartilage overlying the bone consists of a network of collagen fibres. This network is essential to cartilage integrity, usually suffering damage in degenerative joint diseases such as osteoarthritis. We have been applying a number of techniques to study the bone-cartilage interface and of changes occurring in this with disease. The bone-cartilage samples with disease were investigated for their structural, elemental and molecular properties. The bone-cartilage samples with disease were characterized by scanning electron microscopy- energy dispersive X-ray spectroscopy (SEM-EDX) and Fourier Transform infrared spectroscopy (FTIR) and Fourier transform (FT) Raman spectroscopy.
View complete article: PDF  |  Full-text

HIV-1 Molecular Characterization and Transmitted Drug Resistance Prevalence among Treatment-Naïve Individuals

The distribution of different human immunodeficiency virus type 1 (HIV-1) genotypes and the prevalence of transmitted drug resistance (TDR) mutations vary greatly across different Brazilian regions. This study aimed to describe the HIV-1 molecular diversity and TDR prevalence among treatment-naïve HIV-1 infected individuals in an urban area of Northeastern Brazil. DNA samples from 97 infected individuals were obtained and pol sequences were generated by Polimerase Chain Reaction (PCR) and direct sequencing. Bioinformatics tools were used to identify the presence of associated mutations with drug resistance, to reconstruct the phylogeny and to detect recombination.
View complete article: PDF  |  Full-text

Liquid Biopsy in Advanced Gastric Malignancy and Molecular Targeted Therapy; a Case Report and Update Pertaining Anti HER2-Neu Therapy

Human epidermal growth factor receptor 2 (HER2) is responsible for the pathogenesis and poor outcomes of several types of cancers, including advanced gastric and gastroesophageal junction cancer. Molecular-targeted drugs on the other hand, such as trastuzumab, prolong overall survival and progression-free survival in HER2-positive gastric cancer. The purpose of the case report is to evaluate the impact of delivering trastuzumab in advanced gastric cancer with concomitant HER2 mutation and amplification.
View complete article: PDF  |  Full-text

A Model Proposal for Long-Lasting Electromagnetic Forces-Biological System Interaction: Molecular Fatigue Damages

None of the known interaction models of electric and magnetic fields with the biological system can completely explain the effects which occur as a result of long-lasting exposure to electric and magnetic fields. We think that effects which cannot be explained by exposure to long-lasting, and albeit very low, electro-magnetic effects arise from molecular fatigue and the damage accumulation which occurs as a result of it.
View complete article: PDF  |  Full-text

Stability Analysis of Human Islet Amyloid Polypeptide and Its Mutated Oligomeric Forms

Human islet amyloid polypeptide (hIAPP), a 37 residue peptide hormone is an ingenious factor in pancreatic amyloid deposits found in cases with type-2 diabetes. Its aggregation into small toxic oligomeric species is presumed to be the reason for cells debilitation and demise in case of diabetic patients.
View complete article: PDF  |  Full-text

Prospective Evaluation of WHO and European Clinical, Molecular and Pathological (WHO-ECMP) Criteria for Myeloproliferative Neoplasms (MPN) of Various Molecular Etiology: Characteristics of JAK2V617F, MPL515 and CALR Mutated MPN

The WHO defined JAK2V617F mutated myeloproliferative neoplasms (MPN) consist of normocellular essential thrombocythemia (ET), ET with features of early PV (prodromal PV), ET with hypercelular megakaryocytic granulocytic myeloproliferation (ET.MGM), and various stages of polycythemia vera (PV) when the WHO and European Clinical and Pathological (WHO-ECMP) criteria are applied.
View complete article: PDF  |  Full-text

Pregnant Patients with Deep Venous Thrombosis: Management and the Incidence of Thrombophilic Risk Factors

There is lack of knowledge about anticoagulant therapy in pregnancy and an acceptable guide for their use is based on case series and the opinion of scientists. For this reason, we carried out a study on pregnant women suffering from acute deep venous thrombosis (DVT) using enoxaparin twice daily dose.
View complete article: PDF  |  Full-text

A New Bi-Functional Derivative of Polyethylene Glycol as Molecular Carrier for Eugenol and Ibuprofen

Eugenol (EU) and ibuprofene (IBU) were covalently bound to a bi-functionalized PEG, used as molecular carrier of drugs and the release kinetics of the two bioactive molecules was studied in vitro in buffer solution at pH 7.4, in simulated gastric fluid and in mouse plasma.
View complete article: PDF  |  Full-text

Molecular Mechanism Linking BRCA1 Dysfunction to High Grade Serous Epithelial Ovarian Cancers with Peritoneal Permeability and Ascites

Ovarian cancer constitutes the second most common gynecological cancer with a five-year survival rate of 40%. Among the various histotypes associated with hereditary ovarian cancer, high-grade serous epithelial ovarian carcinoma (HGSEOC) is the most predominant and women with inherited mutations in BRCA1 have a lifetime risk of 40-60%. HGSEOC is a challenge for clinical oncologists, due to late presentation of patient, diagnosis and high rate of relapse. Ovarian tumors have a wide range of clinical presentations including development of ascites as a result of deregulated endothelial function thereby causing increased vascular permeability of peritoneal vessels.
View complete article: PDF  |  Full-text

Clinical and Molecular Evaluation of a Case of Male Infertility and Azoospermia

Here we describe the case of a 35 year old male, with a harmonic phenotype, who sought medical assistance to assess the etiology of his infertility. As a result of clinical examination, karyotyping, FISH and molecular studies, we obtained the following karyotype: mos 45,X[18]/46,XY,idic(Y)q(11.2)[82]. Furthermore, the Y chromosome was characterized by the absence of the regions AZF2 (former AZFb, within the 11.22 band, and AZFc, within the 11.23 band), whereas the region AZF1 was conserved. Male infertility can be caused by several genetic alterations.
View complete article: PDF  |  Full-text

Nanotechnology Commercialization: Prospects in India

Nanotechnology manipulates and creates matter to formulate nanometer scale materials and objects. It is an interdisciplinary field that involves a wide range of scientific and engineering disciplines, and has societal implications.
View complete article: PDF  |  Full-text

Molecular Mechanisms of Mismatch Repair Genes in Cancer – A Brief Review

The DNA mismatch repair (MMR) system is necessary for the maintenance of genomic stability. The MMR system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops (IDLs) and heterologies generated during DNA replication and recombination.
View complete article: PDF  |  Full-text


Editorial Board Members Related to Molecular

Muhammad Nasir Afzal

Professor & Director
Department of physiology
College of Medicine, Alfaisal University
Saudi Arabia

Arcady Putilov

Chief Researcher
Research Institute for Molecular Biology and Biophysics
Russia

Qingzhong Kong

Associate Professor
Department of Pathology
Case Western Reserve University
United States

Akira Sugawara

Department of Molecular Endocrinology
Tohoku University Graduate School of Medicine
Japan

Jurgen Konig

Professor
Department of Nutritional Sciences
University of Vienna
Austria

Rodrigo Fernandez Valdivia

Assistant Professor
Department of Pathology
Wayne State University School of Medicine
United States

John V. Planz

Associate Professor
Department of Molecular and Medical Genetics
University of North Texas Health Science Center
United States

Tony Jun Huang

Professor
Department of Engineering Science and Mechanics
Pennsylvania State University
United States

LUIS CLAUDIO NASCIMENTO DA SILVA

Department of Parasitary Biology
Ceuma University
Rua dos Castanheiros Jardim Renascença 65075120 - São Luís
Brazil

Rammurti T. Kamble

Professor of Medicine
Baylor College of Medicine
United States
Submit Manuscript