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Articles Related to Molecular

Homology Modelled Structure of Glutaredoxin 2 from Chlamydomonas reinhardtii

Different types of Glutaredoxins (GRXs) that play a major role in cellular anti-oxidative reactions have been studied for their structure and function from various organisms. Glutathione (GSH), an anti-oxidant with several medical benefits, binds to GRXs. This work has structurally characterized GRX2 from C. reinhardtii (CrGRX2) using biophysical, molecular modelling, and isothermal titration calorimetry (ITC) techniques. CrGRX2 adopts the classical GRX-Trx fold consisting of five β-strands surrounded by four α-helices that bind to GSH with moderate strength through a cysteine residue. The residues involved in the interaction closely match with those observed for E. coli and human counterparts, indicating that the cellular GSH-GRXs antioxidant system is highly conserved.
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Potential Molecular Players Against to SARS-CoV-2: A Glyco-Perspective

COVID-19 is caused by SARS-CoV-2 and is associated with the increasing number of cases and deaths and has been declared a pandemic by WHO. The treatment strategy focused on preventing the S protein from binding and penetrating the ACE-2 receptor. In addition, S protein-related molecules such as peptides, blockers, and inhibitors that inhibit S protein cleavage are considered candidate therapeutics.
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Microscopic Characteristics of Nanoparticles inside the Liquid Suspension by Molecular Dynamics Simulation

Conveying nanopowder or nanoparticles are involved in the numerous industry fields, but discontinuous and unstable transportation often takes place, and even the pipes clogged because of nanoparticle aggregation. Understanding in detailed the microscopic characteristics of nanoparticles suspended in the base fluid will play a vital role.
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Repair of the Molecular Machinery of the Cell at the Nanoscale

In a cellular environment, if any interruption happened due to the initiation of diseases or disorders in cellular events, it can immediately upset the cellular proceedings, and affect the normal life of the cells and tissues. Vital needs are there to repair the cells and tissues. To regain the normal functioning style of cells and associated cellular environment.
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Phenotypic and Genotypic Study of ESBL and MBL Encoding Genes and Molecular Typing in Acinetobacter Baumannii Strains Isolated from Hospitalized Patients

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Envisioning Molecular Network of Obesity by Omics Stratification

To date, Obesity is considered prime concern of public health with multi-dimensional factors engaged in metabolic discrepancy that is rooted from multifactorial causes (i.e., environmental intoxication or genetic abnormality), and the unmet landscape of health care system seeks for therapeutic or preventive measures. Compelling evidence support Omics as strategic tool of systemic biology is benefit to define wiring of molecular circuit in metabolic malfunction and evaluation of metabolic modulator such as synthetic drugs, stem cell replacement, and natural secondary metabolites from various resources.
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Neurobiochemical Roles of Low Molecular Weight Antioxidants on Oxidative Stress Biomarkers and Severity of Ischemic Stroke in Wistar Rats

Purpose: To evaluate the neurobiochemical role(s) of low molecular weight (LMWA) antioxidants in the treatment of surgically- induced ischemic stroke (IS) in wistar rats.Methods: Ischemic stroke was induced in wistar rats using middle cerebral artery occlusion (MCAO). Neurological assessments were carried out using stair case, cylinder test and modified neurological severity score (mnss) methods. Low molecular weight antioxidants (vitamins C, E, α-lipoic acid, dimethyl sulfoxide and mannitol) were orally administered to the rats for two weeks in three different doses (22.5, 45 and 67.5 mg/kg).
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Wildlife Forensic: Current Techniques and their limitations

The wildlife includes undomesticated and diverse forms of floral and faunal species, which is essential for ecological balance and human survival. The poaching and illegal trade has resulted in sharp decline of many wild species of flora and fauna around the world. The need of the time therefore is to utterly focus on wildlife protection for the sustainable development of biosphere and future viability of human beings. In this review we have focused on different techniques being utilized in wildlife forensic science for identification of wildlife species as well as their geographical origin. These techniques can be employed to control the wildlife crimes and convict the criminals involved in illegal trade of wildlife flora, fauna and their products. These techniques include footprints analyses, morphological and anatomical studies,
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Structural, Elemental and Molecular Characterization of Normal And Osteoarthritic Human Articular Cartilage

The articular cartilage overlying the bone consists of a network of collagen fibres. This network is essential to cartilage integrity, usually suffering damage in degenerative joint diseases such as osteoarthritis. We have been applying a number of techniques to study the bone-cartilage interface and of changes occurring in this with disease. The bone-cartilage samples with disease were investigated for their structural, elemental and molecular properties. The bone-cartilage samples with disease were characterized by scanning electron microscopy- energy dispersive X-ray spectroscopy (SEM-EDX) and Fourier Transform infrared spectroscopy (FTIR) and Fourier transform (FT) Raman spectroscopy.
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HIV-1 Molecular Characterization and Transmitted Drug Resistance Prevalence among Treatment-Naïve Individuals

The distribution of different human immunodeficiency virus type 1 (HIV-1) genotypes and the prevalence of transmitted drug resistance (TDR) mutations vary greatly across different Brazilian regions. This study aimed to describe the HIV-1 molecular diversity and TDR prevalence among treatment-naïve HIV-1 infected individuals in an urban area of Northeastern Brazil. DNA samples from 97 infected individuals were obtained and pol sequences were generated by Polimerase Chain Reaction (PCR) and direct sequencing. Bioinformatics tools were used to identify the presence of associated mutations with drug resistance, to reconstruct the phylogeny and to detect recombination.
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Liquid Biopsy in Advanced Gastric Malignancy and Molecular Targeted Therapy; a Case Report and Update Pertaining Anti HER2-Neu Therapy

Human epidermal growth factor receptor 2 (HER2) is responsible for the pathogenesis and poor outcomes of several types of cancers, including advanced gastric and gastroesophageal junction cancer. Molecular-targeted drugs on the other hand, such as trastuzumab, prolong overall survival and progression-free survival in HER2-positive gastric cancer. The purpose of the case report is to evaluate the impact of delivering trastuzumab in advanced gastric cancer with concomitant HER2 mutation and amplification.
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A Model Proposal for Long-Lasting Electromagnetic Forces-Biological System Interaction: Molecular Fatigue Damages

None of the known interaction models of electric and magnetic fields with the biological system can completely explain the effects which occur as a result of long-lasting exposure to electric and magnetic fields. We think that effects which cannot be explained by exposure to long-lasting, and albeit very low, electro-magnetic effects arise from molecular fatigue and the damage accumulation which occurs as a result of it.
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Stability Analysis of Human Islet Amyloid Polypeptide and Its Mutated Oligomeric Forms

Human islet amyloid polypeptide (hIAPP), a 37 residue peptide hormone is an ingenious factor in pancreatic amyloid deposits found in cases with type-2 diabetes. Its aggregation into small toxic oligomeric species is presumed to be the reason for cells debilitation and demise in case of diabetic patients.
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Prospective Evaluation of WHO and European Clinical, Molecular and Pathological (WHO-ECMP) Criteria for Myeloproliferative Neoplasms (MPN) of Various Molecular Etiology: Characteristics of JAK2V617F, MPL515 and CALR Mutated MPN

The WHO defined JAK2V617F mutated myeloproliferative neoplasms (MPN) consist of normocellular essential thrombocythemia (ET), ET with features of early PV (prodromal PV), ET with hypercelular megakaryocytic granulocytic myeloproliferation (ET.MGM), and various stages of polycythemia vera (PV) when the WHO and European Clinical and Pathological (WHO-ECMP) criteria are applied.
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Pregnant Patients with Deep Venous Thrombosis: Management and the Incidence of Thrombophilic Risk Factors

There is lack of knowledge about anticoagulant therapy in pregnancy and an acceptable guide for their use is based on case series and the opinion of scientists. For this reason, we carried out a study on pregnant women suffering from acute deep venous thrombosis (DVT) using enoxaparin twice daily dose.
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Editorial Board Members Related to Molecular

Domenico Rubello

Director
Department of Nuclear Medicine and PET/CT Centre
Santa Maria della Misericordia Hospital
Italy

Marcelo L. Rodriguez-Puebla

Associate Professor
Department of Molecular Biomedical Sciences
North Carolina State University
United States

Francesco Passamonti

Professor of Hematology
University Hospital Ospedale di Circolo
Fondazione Macchi, Varese
Italy

Syed W. Shah

Associate Professor
School of Health Sciences
Universiti Sains Malaysia
Malaysia

Lan-Szu Chou

Associate professor
Department of Bio-Agriculture Sciences
National Chiayi University
Taiwan

MAHENDRA PRATAP SINGH

Toxicogenomics and Predictive Toxicology Division
India

Gyorgy Nagy

Associate Professor
Faculty of Medicine
Semmelweis University
Hungary

QIANG LIU

Professor
School of Life Science
University of Science and Technology
China

LAURA IRIS COSEN-BINKER

Assistant Professor
Department of Molecular and Cell Biology
Boston University
USA

Alain L Fymat

President/CEO and Professor
International Institute of Medicine and Science
Rancho Mirage
California
USA
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