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Urticaria Pigmentosa: Clinical and Dermoscopic Features

We present the case of 18-month-old boy with Urticaria Pigmentosa. Clinical feature was presented as generalized eruption of multiple brown maculopapular lesions on trunk and limbs of one year and 5 months duration. No subjective symptoms were present. First skin lesion occurred in the First month of life. Darier’s sign was positive. Dermoscopy showed a pigment network and a light-brownish blot. Diagnosis of mastocytosis was confirmed by histopathology.
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Predictive Value of ERCC1 Expression on Treatment Response to Cisplatin-Based Regimens in Small Cell Lung Cancer: A Retrospective Analysis

We aimed to determine whether the excision repair cross-complementation group 1 (ERCC1) expression predicts response to cisplatin-based chemotherapy in patients with small cell lung cancer (SCLC). This was a retrospective study, in which hospital files of 31 patients (29 males, 2 females; mean age, 62.26±7.71 years) were reviewed. All patients were treated with etoposide+cisplatin. The lung biopsy and mediastinal lymph node samples were applied anti-human monoclonal antibodies against ERCC1: immunohistochemical staining was considered positive if 25-100% of the cells showed nuclear staining, and negative if less than 25% of the cells showed negative or slight staining. Response to treatment was evaluated as regression (complete or partial response), progressive disease, or stable disease. Of the patients, 18 (58.1%) had limited-stage, and 13 (41.9%) had extensive-stage SCLC. Median follow-up duration was 15 months (range: 1-60 months). ERCC1 staining was positive in 9 of 31 patients (29.0%). In 12 patients (38.7%), tumor regression (complete or partial response) was obtained after chemotherapy. Tumor regression rate was higher in ERCC1 positive patients than those with negative ERCC1 expression (66.7% vs. 27.3%, p=0.036). In conclusion, high expression of ERCC1 was associated with higher response rate to cisplatin-based regimens in patients with SCLC.
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A Clinical Case Study of Paratesticular Rhabdomyosarcoma of Young Adult

Para-testicular rhabdomyosarcoma (RPT) is a rare tumor of children and adolescents. The diagnosis is made by the anatomopathological study. The treatment must be multimodal and involves surgery, chemotherapy and radiotherapy. We report the case of a 19-year-old adolescent in our department for an embryonic-type para-testicular rhabdomyosarcoma. Our aim is to expose a rare and unknown case that may be life-threatening. We would like to emphasize on the fact that paratesticular rhabdomyosarcoma need to be brought up in front of a tissular process expanding in the scrotum with normal testicules.
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Synchronous Papillary Carcinoma in Thyroglossal Duct Cyst and Thyroid Gland Associated to Untreated Midline Cervical Cleft: A Case Report

Thyroglossal duct cyst is the most common anomaly in thyroid development. Majority is benign, but 1% may be malignant. Papillary carcinoma is the most frequent thyroid cancer. The synchronous occurrence of thyroglossal duct cyst and thyroid carcinoma is rare and the association with another congenital malformation is extremely rarer
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Ampullary Localization of Unruptured Ectopic Pregnancy of Eighteen Weeks about a Case

Ectopic pregnancy is therefore implanted out of the normal implantation site of the uterine cavity. It is a surgical emergency that can compromise the vital prognosis and fertility of patients when the diagnosis is made at the stage of rupturing. Its incidence has doubled or even tripled in the world in the last two decades. Although it still remains the leading cause of maternal mortality in the first trimester by tubal rupturing accounting for 13% of maternal deaths this increase is closely linked to several factors such as sexually transmitted infections, history of salpingitis, tubal surgery, abortions, inert or progesterone associated IUD use and smoking. Tubal location is by far the most common (96 to 99% of cases). The clinical signs are therefore relatively late and the rupture of the tube is preceded by a fissure syndrome. We report a rare case of unruptured ampullary pregnancy that has evolved to 18 weeks.
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Squamous Cell Carcinoma of the External Auditory Canal: Case Report

Squamous cell carcinoma of the external auditory canal may masquerade as an infective process causing late diagnosis. A delay in treatment as a result of missed diagnosis would carry a poor prognosis as the disease progresses to an advanced stage. We present a case of a man with history of chronic otorrhea, who developed left sided otalgia associated with hearing loss. otoscopic examination shows a mass in her left ear and pus discharge which was initially treated as an infection. The biopsy of the mass was proven to be squamous cell carcinoma. High index of suspicion is necessary when encountering patients presenting with a mass in the ear canal with prior history of chronic otorrhea or cholesteatoma. Proper tissue biopsy is crucial. Early diagnosis is required for better prognosis for the patient.
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Hydroxyapatite Deposition Disease- Spontaneous Resolution of Significant Post Treatment Deposit

Calcific deposits are commonly seen on imaging done for other reasons. However, it can also present with periarthritis and adhesive capsulitis leading to severe disabling pain. Many theories have been proposed to explain the etiology and it is considered idiopathic by some. The management is also debatable, Barbotage being the most popular. In the majority of the cases it disappears spontaneously, requiring intervention like Barbotage and surgery only in a few cases. We present a case of a 45 year old female patient who had these calcific deposits in an unusual location of her right shoulder. These disappeared partially on conservative treatment. Subsequently, she developed severe pain in her right shoulder with restriction of all her movements. The pain was severe enough to interfere with her sleep. As a result she underwent barbotage. During the procedure an attempt was made to aspirate the calcific deposit in its entirety. This was not possible due to clogging of needle several times. There was complete resolution of pain following the procedure. However, post- procedure Magnetic resonance imaging (MRI) revealed a significant residual calcification which completely resolved 02 months after therapy with no recurrence.
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Granular Cell Tumor of the Tongue: 2 Cases Report and Review of the Literature

Granular cell tumor, also known as Abrikossoff tumor, is a rare lesion that arises from the nervous system. Most of these tumors are benign and only 1-2% are malignant. Although they can be found in any part of the human body, 45-65% appears in the head and neck region, mainly in the oral cavity. Here, we report 2 cases of granular cell tumor of the tongue, diagnosed by excisional biopsy. Until the present moment, both patients remain with no recurrence.
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Role of Serology and Histopathology in Diagnostic of Human Cystic Echinococcosis

Hydatid disease is an important emerging neglected disease worldwide, with significant geographic variation in seroprevalance. The disease is commonly diagnosed on basis of clinical suspicion, imaging and serology. This study was conducted to evaluate our experience with serology in diagnosing hydatid disease in terms of identifying the numbers of patients testing positive for antibodies against Echinococcus, and to study their clinical profile.
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Computer Modeling of Convective Mass Transfer of Glucose, Oxygen and Carbon Dioxide in the Neurovascular Unit

Glucose and oxygen are obligatory energy substrates for the brain and their continuous supply to the neurons, as well as the elimination of the end product – carbon dioxide, is of paramount importance for brain physiology and survival. Transport of these substrates from the brain capillaries to the neurons presents a challenging issue.
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The Dose and its Acute Toxicology: A Systematic Review Article in the First Phase of Experimental Pharmacology

Hundreds and thousands of acute toxicity studies are conducted in experimental pharmacology with assumption hypothesis every year. It is usually concluded with inadequately validated data during the period of investigation within 24 hours.
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Transient Bacteria Removal by Concentrated Sulfuric Acid for Cell Pollution

We found and recommended a method for rapid and effective sterilization by using concentrated sulfuric acid in cell culture.
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Kaempferol 3-glucoside from Azadirachta indica

World population up to 80 percent relies on traditional medicine. Currently use of medicinal plant/herbal medicine for treating various disorders and diseases is quickly evolving. Due to their less side effects. Azadirachta indica (Neem) is one such important medicinal plant widely used in ethno traditional medicine for centuries, which is cosmopolitan in distribution and belongs to the family Meliaceae. In India, it is extensively used in several native medical practices.
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Splenic Abscesses as a Complication of Urinary Tract Infection: Case Report and Literature Review

Granular cell tumor, also known as Abrikossoff tumor, is a rare lesion that arises from the nervous system. Most of these tumors are benign and only 1-2% are malignant. Although they can be found in any part of the human body, 45-65% appears in the head and neck region, mainly in the oral cavity. Here, we report 2 cases of granular cell tumor of the tongue, diagnosed by excisional biopsy. Until the present moment, both patients remain with no recurrence.
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Target Joint “New Concept of Identification”

The hallmark of hemophilia is hemarthrosis. All efforts must be made to early diagnose joint bleeding as soon as it occurs and treat it not later than within 2 h of onset by infusing the appropriate clotting factor. This will prevent the accumulation of blood in the joint as well as inflammation and a potential hemophilic arthropathy. Recurrent bleeding prevents the joint from regaining its range of motion, muscle strength, and normal appearance. These changes become permanent, leading eventually to osteoarthritis. A bleeds joint requires urgent and comprehensive management, especially in young patients, if permanent damage is to be prevented.
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Introduction to the special issue on ‘Nanostructures by Valve Metal Anodization’

With this special issue of JMSN we are pleased to present significant contributions to a fascinating topic in the field of materials nanostructing, which is the anodization of valve metals. By this treatment porous oxides of controlled geometry can be grown on the respective metal surfaces. To date, aluminum (Al) has been used most often, as confirmed in this special issue where nine out of ten contributions deals with its anodization.
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Ordered Growth of Anodic Aluminum Oxide in Galvanostatic and Galvanostatic-Potentiostatic Modes

The results are presented of obtaining anodic aluminum oxide with an ordered pore arrangement by employing two anodizing modes - galvanostatic mode and combined (galvanostatic + potentiostatic) mode, at high values of the current density and voltage. Use has been made of an oxalate electrolyte and a complex electrolyte comprising oxalic acid and phosphoric acid. Scanning electron microscopy has been used to investigate the surface morphology of the barrier and porous layers and to determine pore sizes and inter-pore distance.
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Anodic Porous Alumina Array for Cyanine Fluorophore Cy3 Confinement

Self-organized anodic porous alumina films with hexagonal pore lattice have attracted a considerable attention for biological arrays and confinement of various organic probes dyes in solutions. A molecular structure with axial symmetry in bis-heterocyclic indole chains and conjugate system, such as cyanine fluorophore Cy3 dye, was investigated here with respect to its fluorescence when loaded in the anodic alumina pores.
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Anodizing for Design and Function

Two basic reactions occur during the anodizing of aluminum: 1) the aluminum is consumed and 2) an oxide grows. By accepting this statement as true, the anodizing process can be viewed as a corrosion process, and anodizing can be modeled using the Tafel Equation. Anodizing process parameters of electrolyte chemistry and concentration, temperature, aluminum substrate resistance and current density are presented as they relate to the Tafel Equation and how they impact the anodic aluminum oxide structure and properties. Understanding this relationship is consequent in making anodizing an engineering process, one that enables tuning the structure such that it yields distinct characteristics to fulfill design and application requirements.
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Recent Developments in Human Odor Detection Technologies

Human odor detection technologies have drawn attention due to the wide possibility of potential applications they open up in areas such as biometrics, criminal investigation and forensics, search for survivors under rubble, and security checkpoint screening. Gas chromatography/mass spectrometry (GC/MS) has been the most successful and powerful analytical approach developed to date for human odor analysis, and hundreds of human odorants have been identified using this tool.
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Electronic-nose Applications in Forensic Science and for Analysis of Volatile Biomarkers in the Human Breath

The application of electronic-nose (E-nose) technologies in forensic science is a recent new development following a long history of progress in the development of diverse applications in the related biomedical and pharmaceutical fields. Data from forensic analyses must satisfy the needs and requirements of both the scientific and legal communities. The type of data collected from electronic-nose devices provides a means of identifying specific types of information about the chemical nature of evidentiary objects and samples under investigation using aroma signature profiles of complex gaseous mixtures containing volatile organic compounds (VOCs) released from manufactured products and parts of the human body. E-nose analyses also provide useful qualitative information about the physicochemical characteristics and metabolic conditions of human subjects without the need for time-consuming analyses to identify all chemical components in human-derived volatile mixtures.
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Analysis of Sweat Simulant Mixtures using Multiplexed Arrays of DNA-Carbon Nanotube Vapor Sensors

Carbon nanotube (NT) based electronic vapor sensors were tested against synthetic sweat solutions, consisting of 13 volatile organic compounds (VOCs) in saline, in order to probe the device ability to analyze and differentiate vapors derived from complex biological samples.
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Characteristic Human Scent Compounds Trapped on Natural and Synthetic Fabrics as analyzed by SPME-GC/MS

The collection of human odor volatiles is of interest to forensic applications as a path to investigate canine scent discriminations in legal investigations. A study using a selected array of previously identified human odor compounds has been conducted to determine the retention and release capabilities of five (5) natural and synthetic fabric types, cotton (mercerized fabric and gauze matrix), polyester, rayon and wool.
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The Effects of the Film Thickness and Roughness in the Anodization Process of Very Thin Aluminum Films

The anodization of aluminum foils having micrometer thickness is a common process and results in hexagonally self-ordered alumina membranes. However, anodic aluminum oxide (AAO) membranes fabricated from nanometer-thin films present new challenges to the anodization process, since aluminum films adheres poorly on supporting substrates and the smoothness of the film is highly related to the kind of substrate.
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Anodic Oxidation of Titanium in Sulphuric Acid and Phosphoric Acid Electrolytes

Anodisation of pure titanium has been carried out in sulphuric and in phosphoric acid solutions at potentials ranging from 50 to 150V. The SEM and AFM morphological analysis indicates that, within this potential range, oxidation in sulphuric acid solution produces better developed mesoporous oxide layers.
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Fabrication of Ordered Arrays of Anodic Aluminum Oxide Pores with Interpore Distance Smaller than the Pitch of Nano-pits formed by Ion Beam Etching

We investigated a method for preparation of ordered nanopore arrays with the interpore distance of 60 nm by guided self-organization of anodic aluminum oxide with a prepatterned array of pits in the starting Al film.
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Preparation of Large Area Anodic Alumina Membranes and their Application to Thin Film Fuel Cell

The design of an electrochemical reactor for the preparation of self-supported comparatively thin (up to 10 μm) and large area (up to 50 cm2) anodic alumina membranes is described allowing growth of porous alumina at high applied potential (up to 150 V) without burning.
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Fabrication of Vertical Cu2ZnSnS4 Nanowire Arrays by Two-Step Electroplating Method into Anodic Aluminum Oxide Template

Vertical Cu2ZnSnS4 (CZTS) nanowire arrays have been synthesized via two-step electroplating method into anodized aluminum oxide template. For deposition of CZTS nanowires, anodized aluminum oxide (AAO) was used as the growth mask for the growth of the nanowires. AAO templates with hole sizes of 70 nm in diameter were used in the experiments.
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Fabrication and Luminescence of Anodic Alumina with Incorporated Vanadyl Citrate Chelate Anions

Anodic aluminum oxide doped with vanadyl citrate chelate complex anions was formed by a two-step self-organized anodization in 2 wt. % sulfuric acid containing 0.04 M V2O5 and 0.08 M citric acid at voltage range 13-23 V, and at 0 and 15 oC. The combination of two temperatures and at least four voltages (depending on the applied temperature) was applied as the operating conditions of anodization.
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Synthesis of BaTiO3 Nanowires via Anodic Aluminum Oxide Template Method Assisted by Vacuum-and-Drop Loading

In this paper, we report on the synthesis of BaTiO3 nanowires via the anodic aluminum oxide template method. To fill in the precursors of BaTiO3 into anodic aluminum oxide templates, the vacuum and drop loading method developed in our previous study was used. Ba(CH3COO)2 (barium acetate) and C12H28O4Ti (tetraisopropyl orthotitanate) were used as Ba and Ti sources, respectively. Anodic aluminum oxide membranes with the through-hole diameter of ~200 nm were used as the template for BaTiO3 nanowires.
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Editorial Board Members Related to

Jack Ho WONG

Research Associate
School of Biomedical Sciences
Faculty of Medicine
The Chinese University of Hong Kong
Hong Kong

ALBA A. TRESPALACIOS

Professor
Department of Microbiology
Pontificia Universidad Javeriana
Colombia

Jing-Huei Lee

Professor
Department of Biomedical, Chemical, and Environmental Engineering
University of Cincinnati
United States

Burton M. Altura

Professor
Department of Medicine
Suny downstate medical center
United States

Jack Ho Wong

School of Biomedical Sciences
Chinese University of Hong Kong
Hong Kong

P. S. SURESH

Assistant Professor
Department of Bio-Sciences
Mangalore University
India

Konstantin N Konstantinov

Professor
Department of Internal Medicine
University of New Mexico
United States

Hung-Ming Chang

Professor
Department of Anatomy and Cell Biology
College of Medicine
Taipei Medical University
Taiwan

Guo-Zhang Zhu

Professor
Department of Biological Sciences
Marshall University
United States

Ana Cristina Lindsay

Associate Professor
Department of Nutrition
University of Massachusetts Boston
United States
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