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Articles Related to MIC

Economic Prospects in the Production of Bee Venom and Bee Venom Products from the Aspect of Application in Medical and Cosmetological Therapies

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Leptin Receptor Gene Variant Rs1137101 and Ghrelin Gene Variant Rs696217 are Associated with Body Mass Index in Brazilian Population: A Case-Control Study

Introduction: Obesity is a multifactorial condition influenced by environment and genetic factors. Controlling appetite and satiety involves complex interactions between the hypothalamus, which is responsible for homeostasis regulation energy, and hormones that regulate appetite including leptin and ghrelin. Leptin plays an important role in the regulation of food intake and energy expenditure, generating an increase in energy burning and decreasing food intake. And ghrelin is directly involved in the regulation of short-term energy balance. Objectives: To verify frequency, biochemical profile and Body Mass Index (BMI) variations according to SNPs in LEPR and GHRL gene. Subjects and Methods: 163 both genders subjects were classified into Study Group (SG): 103 subjects with obesity; Control Group (CG): 60 non-obese. Blood samples were collected to perform DNA extraction and biochemical profile analysis. Statistical significance was established at p < 0.05. Results: The genotype and allele frequency were similar between groups for both polymorphisms. The _/A genotype of the GHRL rs696217 polymorphism was associated to increased BMI in SG compared CG (p = 0.003) and increased triglycerides (TG) and very low density lipoprotein (VLDLc) values in CG (p < 0, 05). The _/A genotype was also associated with increased fasting glucose compared to CC genotype only in CG (p = 0.031). Considering the LEPR rs1137101 polymorphism, AA genotype subjects presented higher BMI compared to _/G genotype subjects (p = 0.024). No difference between biochemical profile variables related to LEPR rs1137101 polymorphism was found. Conclusion: AA genotypes of the LEPR rs1137101 polymorphism and _/A of the GHRL rs696217 polymorphism suggest being risk factors for BMI and the latter is associated with fasting glucose, VLDLc and TG variation.
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Elexacaftor/Tezacaftor/Ivacaftor Improves Glycemic Control in Pediatric Patients with Cystic Fibrosis-Related Diabetes

Cystic fibrosis (CF) is an inherited disorder caused by genetic mutations encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) is a CFTR modulator shown to improve lung function in certain patients with CF. We undertook this study to determine its effects on glycemic outcomes in pediatric patients with cystic fibrosis-related diabetes (CFRD). We reviewed the medical records and identified two subjects, referred to as subject A and subject B, with CFRD on insulin therapy at Duke University Hospital between 2019-2020 who were on treatment with ELX/TEZ/IVA for at least one year. The mean hgbA1C pre- and post- treatment was 5.65% (5.6-5.7) and 5.05% (5.0-5.1) respectively with a mean reduction of 0.6% (p value 0.01). Improvement in hgbA1C occurred in the absence of increased insulin requirements, subject B remained on a similar insulin regimen whereas subject A was able to come off insulin completely. In addition, improvements in BMI z-score were seen in both groups with a mean BMI z-score of -0.30 pre-treatment (-0.71-0.11) and z-score of +0.28 post-treatment (0.11-0.45).
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Isolation of Microorganisms Associated with Palm Oil Contaminated Soil

Aim: Palm oil processing generally generates lots of wastewater (palm oil mill effluent), this is usually discharged into the environment in the untreated form and subsequently causes several environmental issues. There is therefore need to isolate microorganisms that can be used to clean up the palm oil contaminated environment especially the soil. Methods and Results: Palm oil contaminated soil was obtained from Oba Adeyemi palm oil mill in Oyo, Oyo State, Nigeria, other soil samples which were purposely contaminated with palm oil, were obtained from Ajayi Crowther University Oyo, Oyo State. Isolation, characterization and identification of microorganisms were carried out using morphological and biochemical characterization. The isolates were preliminarily screened for lipolytic activities, this was confirmed by growth on the mineral salt medium after 7 days, signifying hydrolysis. One of the prominent isolates was further identified by sequences analysis of 16S rRNA genes. Forty-one bacterial isolates were identified, which included species of Bacillus (80 %), Pseudomonas (20 %) in the oil mill contaminated soil sample and Bacillus spp. (100 %) in the purposely contaminated soils. Twenty-nine fungal isolates including species of Aspergillus, Oidiodendron, Geotrichum, Penicillum, Saccharomyces were isolated with Aspergillus fumigatus having the highest frequency of occurrence (37.5 %) in artificially contaminated soil and Saccharomyces spp. having the highest frequency of occurrence (91 %) in palm oil contaminated soil from the palm oil mill. Sequencing of the 16S rRNA of one of the prominent isolates showed that it was identified as MN607220 Saccharomyces cerevisae. All the bacterial and fungal isolates had lipolytic activities except Bacillus mycoides and Oidiodendron sp. respectively. Nine of the ten Saccharomyces sp. had lipolytic activities. Conclusion: These screened organisms could therefore be employed for the cleanup of palm oil contamination in the environment. Significance and Impact of Study: Thereby ridding the environment of possible toxic effects especially in areas of need like Malaysia
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Distribution of Dengue Virus Serotypes during the COVID 19 Pandemic in Sri Lanka

Background: Dengue virus (DENV) infection is highly endemic in Sri Lanka with frequent epidemics. Knowledge on DENV serotype distribution will provide important information on impending epidemics. Understanding the disease burden of DENV infection during COVID-19 pandemic is highly important. Objective: To analyze the incidence of DENV infection and serotype distribution among clinically suspected patients with DENV infection during COVID-19 pandemic in Sri Lanka. Study Design: This retrospective study analyzed 1796 plasma samples from patients with clinically suspected DENV infection received at Medical Research Institute (MRI), for testing of DENV RNA, from May 2019 to April 2021. Detection of viraemia and serotypes was performed using a commercially-validated serotyping real-time Reverse Transcriptase Polymerase Chain Reaction (RT-PCR). Demographic and clinical details were recruited from accompanying request forms. Results were analyzed using descriptive statistics and chi square testing. Results: Of the samples 69.2% (n=1243) became positive for DENV RNA with 55.34% (n=688) belonging to patients under 16 years and 20.99%(n=261) to patients with severe infection. The vireamic rate ranged from 31.9% to 80.12% during different quarters of the study period. DENV-2 was detected in 40.2% (n=500) followed by DENV-3(37.97%,n=472) and DENV-1(15.44%,n=192) while co-infection with two different serotypes was observed in 5.79%(n=72). DENV3(47.5%,n=124) and DENV-2(39.46%, n=103) exhibited high percentage of positivity among patients with severe infection. Conclusions: Incidence of Dengue virus infection in Sri Lanka showed a noticeable decrease during study period. DENV2 and DENV-3 exhibited dominance with re-emergence of DENV-1 and co-infection with multiple serotypes. DENV-2 and DENV-3 were detected with severe infection predominantly.
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Biomarkers of Microbial Dysbiosis as Causative Agent of Acute Diarrhea in Dogs

Dysbiosis is microbial imbalance and mostly common in gastrointestinal tract [1]. There is a significant different of microbial communities in diarrheic cases more than healthy dogs’ comparison of gender & clinical signs. Clostridium species is mostly commonly genus found infectious animal cases of diarrhea and moreover in dog in other hand unclassified genus of Ruminococcaceae Bacteroidetes and Faecali bacterium were isolated. The microbiome functional gene content of (PICRUSt) with elevation gastric enzymes & increase titers infra structural proteins in acute diarrhea. Studies and data for dysbiosis with different intestinal disorders in dog associated with acute diarrhea or chronic is very limited. Current study to evaluate microbial dysbiosis. The fecal microbiome, characterized by 655 pyrosequencing of the different genes, AU/CG. There was lower range of bacterial isolates from cases of acute diarrhea compared to animal variation with statistical analysis. Altered microbial imbalance in gut occur with the microbial communities for gastric infection.
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Ethnobotanical Study of ARTEMISIA IFRANENSIS J. DIDIER in Timahdite Region (Central Middle Atlas of Morocco)

With the purpose of valorizing the aromatic and medicinal plants, essentielly the Asteraceae family, and ethnopharmacological heritage in the area of Timahdite province of Ifrane, Morocco. An fieldwork has been carried and consists of conducting an ethnobotanical survey on Artemisia ifranensis J. Didier, endemic species, in the region of Timahdite, located in the Moroccan Middle Atlas. The Ethnobotanical study realised in June-July 2012 beside 82 different respondents permitted to describe their medicinal use at the local scale based on the local Known-how, and constitute a source of very precious information for the area studied and for subsequent researches for the domains of the phytochemistry and pharmacology in order to search for new natural substance. In tyhis study, the survey targeted men (70 %) and women (30 %), aged 30 to 50 years and The data Analysis showed that the overall level of schooling of the town was low (64% of the illiterate). The results of the study also had allowed to notice that the leaves was the usual used part (61 %). Most remedies are prepared in decoction (72%). Either, the survey revealed that the medicinal specie was mainly used against diseases of the digestive tract (63%), as well as for other treatment of various diseases as dermatological affection, and for relieving headaches or neuralgia. Moreover, it also comes out from it that the conservation and the sustainable management of the medicinal species identified should be ensured through a management plan.
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Does Pre-Workout Supplement Consumption Affect Enamel Microhardness?

The aim of this study was to compare in vitro the micro hardness of enamel exposed to the erosive effects of three pre-workout drinks. Forty blocks (4mmx4mm) of bovine enamel were randomly selected and divided among the following pre-workout drinks (n=10): G1: Universal Shock Therapy®, G2: 1.M.R Vortex™, G3: Jack3Dmicro™, G4: Control (distilled water). The enamel microhardness was evaluated before (T1) and after (T2) the in vitro erosive test (5 min/3 times/5 days) using a Vickers digital microduremeter (load 100g/penetration 15s). The data was analyzed using descriptive statistics (mean, ±sd) and for comparison testing, using the Kruskall Wallis test and the t Student test (p≤ 0.05). All groups showed a reduction in micro hardness after the erosive test (p =0.001).1.M.R Vortex™ drink showed a large decrease in micro hardness (%SMH:34,92%). Pre-workout drinks significantly decreased the superficial micro hardness of enamel
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Demographic and Socioeconomic Influence on Antenatal Care Utilization Among Pregnant Women in Wa Municipality of The Upper West Region of Ghana

Introduction: It remains unclear if benefits of antenatal care can be attributed to the amount and content of care or to uncontrolled risk factors that might also affect its use. An understanding of the factors influencing antenatal care is still a challenge because the pathways through which the effects are obtained remain elusive. Objective: The study examined the factor influencing antenatal care utilisation in the Wa Municipality. Methodology and Data: The study employed a retrospective cohort design. The probability proportionate to size sampling was used to select the sub-district health catchment facilities, while the systematic random sampling was used to select respondents. Data was collected from 353 women based on the status of Antenatal care utilization. Results: The results suggest that the educational status, maternal knowledge on adequacy of four or more antenatal care, score for general services received, number of tetanus toxoid doses received and anaemia status at Antenatal care registration were significant predictors to adequate antenatal care utilization. Conclusion: The study further found that women who had anaemia at antenatal care registration, General quality of received women received at antenatal care, level of Tetanus doses as well as knowledge on the adequacy of antenatal care were significant factors that influence antenatal care usage among reproductive aged women in the Wa municipality. The implication is that, attention should be drawn by health management authorities to ensure an improvement in the coverage antenatal care in Wa Municipal while health staff are encouraged to enforce to the latter all due protocols in the discharge of their duties at antenatal care utilisation in Ghana
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Pharmacodynamic Equivalence of Ovine Enoxaparin to Porcine Enoxaparin (Lovenox®) In Healthy Volunteers: A Randomized, Open-Label, 2-Way Cross-Over, Single Dose Study

Aim: to demonstrate the PK/PD equivalence of an ovine enoxaparin to the reference product, the originator porcine enoxaparin, Lovenox® from Sanofi, and to assess its safety and tolerability in healthy volunteers with s.c. administration. Methods: a randomized, open-label, 2-way cross-over, single-dose study with 7 days wash-out period was conducted in healthy volunteers of both sexes. A single s.c. injection of 6,000 IU ovine enoxaparin from Metiska Farma (the test drug, T) or Lovenox® from Sanofi (the reference drug, R) was given randomly to each subject in fasting condition. The PD endpoints measured were anti-FXa and anti-FIIa activities in plasma, whereas the PD parameters determined for these endpoints were AUEC0-t (area under the effect curve from time 0 to the last measured activity (t)) and Amax (maximum activity). Bioequivalence (BE) is based on anti-FXa activity, the 90% CIs for GMR T/R (geometric means ratio of Test/ Reference) of AUEC0-t and Amax must fall within the BE limits of 80.00 – 125.00%. The anti-FIIa data are in vivo supportive evidence only. Results: a total of 23 healthy volunteers completed this study. The 90% CIs for GMR T/R of AUEC0-t and Amax for anti-FXa were 107.55 – 116.33% and 110.17 – 117.68%, respectively, while those for anti-FIIa were 100.93 – 122.56% and 105.19 – 124.44%, respectively. All parameters fell within the BE criteria of 80.00 – 125.00%. One AE (adverse event) occurred in one volunteer after s.c. injection of ovine enoxaparin, i.e. bruising which disappeared after a few days. Conclusions: the ovine enoxaparin from Metiska Farma was bioequivalent to the reference porcine enoxaparin (Lovenox®) from Sanofi. Both enoxaparin products were shown to have high safety and tolerability after a single dose in healthy volunteers. This is the first study showing BE of a nonporcine enoxaparin to the reference porcine enoxaparin in Indonesia, a Moslem country
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A Web-Based Nutrition Education Study in Alabama Black-Belt Counties During the Covid-19 Pandemic

Overweight and obesity continue to be health-related issues in Alabama Black-Belt Counties with rates ranging from 35 to 48%. We aimed to determine the impact of a web-based nutrition education and physical activity intervention on participants’ health in Alabama Black Belt counties during the COVID-19 pandemic. Nutrition education was delivered to participants through a zoom online platform for 12 weeks. Participants’ knowledge, attitudes, and practices as well as changes in nutrition knowledge, anthropometry, and blood pressure were determined through online surveys. Of the participants, (100%) indicated that overweight and obesity are a result of unhealthy lifestyles, whereas 90.7% reported that obesity increased the risk of high blood pressure (90.7%), diabetes (86.04%), and heart disease (90.7%). Results showed that participants’ income was a significant determinant of their perception for the role of schools in fighting obesity (χ2=0.04). Similarly, data revealed that the age of participants was a significant factor for: their desire to learn more about obesity (χ2=0.04), perception of their knowledge of overweight and obesity compared to the average person (χ2=0.01), and the perception that they had an excellent knowledge of overweight and obesity (χ2=0.05). There were significant improvements in knowledge scores. Results showed a significant decline in waist circumference (p<0.001) and hip circumference (p<0.02); 60% of the participants showed a decline in bodyweight; 43% lost more than 1-5kg, while 9.8% maintained their baseline weight. Web-based virtual interactions may effectively substitute or complement face-face nutrition education and lead to a reduction of overweight and obesity in Alabama Black-Belt counties.
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Hypoglycemic Potential of Ziziphus spina-christi Fruit on Alloxan induced Hyperglycemic Rats

Hyperglycaemia is a key symptom in diabetes mellitus associated with long term damages, dysfunction and eventually failure of organs, especially the eyes, kidneys, nerves, heart and blood vessels. This study is to evaluate the hypoglycaemic potential of orally administered aqueous and ethanol extracts of Zyziphus spina-christ fruit on alloxan induced hyperglycaemic Wistar rats. The plant was extracted using maceration using aqueous and 80% ethanol as extraction solvents. Qualitative phytochemical analysis was done. An in vitro assessment of both aqueous and ethanol extract to demonstrate hypoglycaemic activity via inhibition of alpha amylase enzyme and alpha glucosidase enzymes were done. Total of 45 albino rats were used in the study of both sexes divided in 9 groups. Group 1: normal control group, group 2: diabetic control group, group 3: positive control group (metformin 300mg/kg), group 4-6: (150mg/kg, 300mg/kg and 600mg/kg) aqueous extract and group 7-9: (150mg/kg, 300mg/kg and 600mg/kg) ethanol extract. Groups were compared using one way ANOVA for significant differences and Dunnet’s posthoc test was deployed were differences exit. Data were represented as mean ± SEM and p value <0.005 The aqueous and ethanol extract yielded 35.59%% and 46.68% respectively. Phytochemical analysis revealed the presence of alkaloids, flavonoids, terpenoids, tannins, Saponins, Saponins glycosides, steroids, Phytosteroids, carbohydrate and volatile oil. An in vitro assessment of aqueous and ethanol extract demonstrated hypoglycaemic activity via inhibition of both alpha amylase enzyme and alpha glucosidase enzymes. The percentage inhibition of alpha amylase was presented as IC50 of 0.14, 0.19 and 0.58 for the acarbose, ethanol extract and aqueous extract respectively. Alpha glucosidase inhibition was represented by the IC50 of 0.7mg/ml, 0.9mg/ml and 0.7mg/ml for acarbose, ethanol extracts and aqueous extracts. The aqueous and ethanol extracts significantly decrease the blood glucose level. Elevation of cholesterol and LDL was seen in diabetic control group. The results from the studies showed that Ziziphus spina-Christi fruit aqueous and ethanol extracts has an anti-hyperglycaemic potential which is not a dose dependent both in Vitro and in Vivo. Ziziphus spina-Christi fruit aqueous and ethanol extract also causes a significant reduction in cholesterol level.
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A Rare Case of Albrights Hereditary Osteodystrophy presenting as Recurrent Hypocalcemic Tetany

An internist with an eagle’s eye can diagnose many hidden diseases through careful examination. One such hereditary metabolic disorder is Albright’s Hereditary Osteodystrophy (AHO). Characteristic presentations in an individual affected by AHO were short stature, obesity, mild mental retardation and brachydactyly especially of 4th and 5th digits, which are the phenotypic features of genetic mutation. Pseudohypoparathyroidism (PHP) is characterized by inability of the body to respond appropriately to parathormone, mainly characterized by hypocalcaemia, increased serum parathormone concentration, insensitivity to the biological activity of parathormone and hyperphosphatemia. AHO when seen in association with resistance to parathormone (PTH), it is called PHP. Here is a case report of 22-year-old female patient with AHO with distinctive physical characteristics who presented to us with recurrent hypocalcaemic tetan
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2D Analysis of Piezoelectric Layer Over a Rotating Micro-elongated Thermoelastic Medium with DPL Model

The Lord-Shulman theory with one relaxation time and the dual-phase-lag model with two relaxation times of thermoelasticity are used in this article to study the influence rotation micro-elongated thermoelastic layer, when a piezo electric layer is above it. To convert a partial differential equation to an ordinary differential equation, the normal mode method is utilized. Numerical computations are implemented for aluminum epoxy, and the results are charted. A comparison is made among the two theories in the complete absence and the presence of a rotation. The presence of a rotation has a major effect on all physical quantities.
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An Accidental Intrathecal Injection of Tranexamic Acid: A Never Miss Event

Several factors have been identified as contributing to medical errors such as labels, appearance, and location of ampules. In this paper, inadvertent intrathecal Injection of tranexamic acid has resulted from similarities in appearance between tranexamic acid and heavy bupivacaine 0.5% ampoules. The patient experienced severe itching in the gluteal region followed by generalized myoclonic seizures after accidental intrathecal administration of tranexamic acid.
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Ordered Growth of Anodic Aluminum Oxide in Galvanostatic and Galvanostatic-Potentiostatic Modes

The results are presented of obtaining anodic aluminum oxide with an ordered pore arrangement by employing two anodizing modes - galvanostatic mode and combined (galvanostatic + potentiostatic) mode, at high values of the current density and voltage. Use has been made of an oxalate electrolyte and a complex electrolyte comprising oxalic acid and phosphoric acid. Scanning electron microscopy has been used to investigate the surface morphology of the barrier and porous layers and to determine pore sizes and inter-pore distance.
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Electronic-nose Applications in Forensic Science and for Analysis of Volatile Biomarkers in the Human Breath

The application of electronic-nose (E-nose) technologies in forensic science is a recent new development following a long history of progress in the development of diverse applications in the related biomedical and pharmaceutical fields. Data from forensic analyses must satisfy the needs and requirements of both the scientific and legal communities. The type of data collected from electronic-nose devices provides a means of identifying specific types of information about the chemical nature of evidentiary objects and samples under investigation using aroma signature profiles of complex gaseous mixtures containing volatile organic compounds (VOCs) released from manufactured products and parts of the human body. E-nose analyses also provide useful qualitative information about the physicochemical characteristics and metabolic conditions of human subjects without the need for time-consuming analyses to identify all chemical components in human-derived volatile mixtures.
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Characteristic Human Scent Compounds Trapped on Natural and Synthetic Fabrics as analyzed by SPME-GC/MS

The collection of human odor volatiles is of interest to forensic applications as a path to investigate canine scent discriminations in legal investigations. A study using a selected array of previously identified human odor compounds has been conducted to determine the retention and release capabilities of five (5) natural and synthetic fabric types, cotton (mercerized fabric and gauze matrix), polyester, rayon and wool.
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The Effects of the Film Thickness and Roughness in the Anodization Process of Very Thin Aluminum Films

The anodization of aluminum foils having micrometer thickness is a common process and results in hexagonally self-ordered alumina membranes. However, anodic aluminum oxide (AAO) membranes fabricated from nanometer-thin films present new challenges to the anodization process, since aluminum films adheres poorly on supporting substrates and the smoothness of the film is highly related to the kind of substrate.
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Anodic Oxidation of Titanium in Sulphuric Acid and Phosphoric Acid Electrolytes

Anodisation of pure titanium has been carried out in sulphuric and in phosphoric acid solutions at potentials ranging from 50 to 150V. The SEM and AFM morphological analysis indicates that, within this potential range, oxidation in sulphuric acid solution produces better developed mesoporous oxide layers.
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Preparation of Large Area Anodic Alumina Membranes and their Application to Thin Film Fuel Cell

The design of an electrochemical reactor for the preparation of self-supported comparatively thin (up to 10 μm) and large area (up to 50 cm2) anodic alumina membranes is described allowing growth of porous alumina at high applied potential (up to 150 V) without burning.
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Fabrication of Vertical Cu2ZnSnS4 Nanowire Arrays by Two-Step Electroplating Method into Anodic Aluminum Oxide Template

Vertical Cu2ZnSnS4 (CZTS) nanowire arrays have been synthesized via two-step electroplating method into anodized aluminum oxide template. For deposition of CZTS nanowires, anodized aluminum oxide (AAO) was used as the growth mask for the growth of the nanowires. AAO templates with hole sizes of 70 nm in diameter were used in the experiments.
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Fabrication and Luminescence of Anodic Alumina with Incorporated Vanadyl Citrate Chelate Anions

Anodic aluminum oxide doped with vanadyl citrate chelate complex anions was formed by a two-step self-organized anodization in 2 wt. % sulfuric acid containing 0.04 M V2O5 and 0.08 M citric acid at voltage range 13-23 V, and at 0 and 15 oC. The combination of two temperatures and at least four voltages (depending on the applied temperature) was applied as the operating conditions of anodization.
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Synthesis of BaTiO3 Nanowires via Anodic Aluminum Oxide Template Method Assisted by Vacuum-and-Drop Loading

In this paper, we report on the synthesis of BaTiO3 nanowires via the anodic aluminum oxide template method. To fill in the precursors of BaTiO3 into anodic aluminum oxide templates, the vacuum and drop loading method developed in our previous study was used. Ba(CH3COO)2 (barium acetate) and C12H28O4Ti (tetraisopropyl orthotitanate) were used as Ba and Ti sources, respectively. Anodic aluminum oxide membranes with the through-hole diameter of ~200 nm were used as the template for BaTiO3 nanowires.
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Editorial Board Members Related to MIC


Medical School
University of Athens

Wynand S. Verwoerd

Senior Lecturer
Department of Wine, Food & Molecular Biosciences
Lincoln University
New Zealand

Salam A. Ibrahim

Food and Nutritional Sciences
North Carolina A&T State University

Junxian He

Assistant professor
State Key Laboratory of Agrobiotechnology
The Chinese University of Hong Kong
Hong kong

Peter L. Bordi

Associate Professor
School of Hospitality Management
Pennsylvania State University
United States

Hongxia Hao

Department of Chemistry
University of Toronto

Bakhtiar Affendi Rosdi

Senior Lecturer
School of Electrical and Electronic Engineering
Universiti Sains Malaysia

Jurgen Konig

Department of Nutritional Sciences
University of Vienna

Jana Barlic-Dicen

Assistant Professor
Department of Cell Biology
University of Oklahoma Health Sciences Center
United States


Associate Professor
Department of Microbiology and Molecular Cell Biology
Eastern Virginia Medical School
United States
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