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Articles Related to OIE

Novel Antibiotics for Bloodstream Infections in HSCT

Bloodstream infections (BSI) are one of severe infectious complications faced by hematopoietic stem cell transplantation (HSCT) patients. BSI increases significantly the morbidity and mortality of HSCT patients. Gram-positive bacteria occurred more frequency than gram-negative bacteria over past decades, but rates of gram-negative bloodstream infections have recently increased again. Antibacterial prophylaxis could be justified in HSCT, infections caused by resistant pathogens increased mortality. New antibiotics such as omadacycline, meropenem/vaborbactam, eravacycline, ceftobiprole, tedizolid, dalbavancin, cefiderocol hold promise for the treatment of highly resistant pathogens.
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Changes in Several Disease Parameters Including Abzymes and Hematopoietic Progenitor Colony Formation in Brain Inflammation and Demyelination

Demyelination induced by cuprizone-is a widely used experimental model to analyze processes of re- and demyelination in the central nervous system (CNS). Here we used C57BL/6 mice; a model of experimental autoimmune encephalomyelitis (EAE) mimicking important aspects of human multiple sclerosis, to evaluate effects of cuprizone-dependent demyelination on different parameters associated with autoimmune inflammation. The treatment of mice with cuprizone leads to a significant decrease of several indexes characterizing spontaneous and myelin oligodendrocyte glycoprotein (MOG35-55)
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Gross and Histopathological Alterations in Experimental Trypanosoma Evansi Infection in Donkeys and the Effect of Isometamidium Chloride Treatment

Trypanosoma evansi (T. evansi) infection causes wasting and fatal animal trypanosomosis. This study was aimed at determining the gross and histopathological alterations in donkeys experimentally infected with T. evansi and the effect of isometamidium chloride treatment. Apparently healthy donkeys (N=18) of mixed sexes were randomly assigned to 3 groups; A1 (Infected-untreated), A2 (Infected, isometamidium-treated) and B (Uninfected, control) of six animals each. Each animal in infected groups had about 2.0x106 T. evansi injected through the jugular vein. Parasitaemia levels were evaluated using HCT and Mice Inoculation Test (support test). Gross and histopathological examinations were also conducted post-infection and post-treatment.
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Treosulfan Plus Fludarabine – Encouraging Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation in Multiple Myeloma

Allogeneic transplantation (Allo-SCT) in multiple myeloma is controversial mainly due to the relatively high non-relapse mortality (NRM). The aim with this retrospective single-center study was to evaluate recent transplants particularly after conditioning with treosulfan plus fludarabine (TreoFlu).
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Responses and Survival under Pegylated Interferon α2a Treatment for Patients with Post-MPN Acute Myeloid Leukemia and Acute Panmyelosis with Myelofibrosis

We report here for the first time the efficacy of pegylated interferon α2a (Peg-Ifn) as a therapy for patients with myelofibrosis and high blast counts. We treated four patients who were in an accelerated phase of myeloproliferative neoplasms or acute panmyelosis with myelofibrosis using only this drug.
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Spinal Cord Compression Due to Extramedullary Hematopoiesis in a 27-Year-Old Man with Beta Thalassemia Intermedia: A Case Report

Extramedullary hematopoiesis (EMH) occurs in approximately 15% of cases of thalassemia. Paraspinal mass of extramedullary hematopoiesis are a rare compensatory process in intermediate and severe thalassemia.
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Congenital Dyserythropoietic Anemia Type III and Primary Hemochromatosis; Coexistence of Mutations in KIF23 and HFE

Congenital dyserythropoietic anemia type III (CDA III) can be caused by mutation in KIF23. CDA III differs from CDA I and II in the sense that secondary hemochromatosis has not been reported. However, we have observed elevated serum ferritin in a CDA III family.
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Mesenchymal Stem Cells from Different Tissues: Immune Status and Activity

Mesenchymal stem cells (MSCs) have been found in almost all tissues and due to their regenerative properties represent promising tools in cell-based therapy. Role of MSCs in tissue repair is strongly governed by their interplay with immune cells and regulating factors.
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Extramedullary Hematopoiesis in a Non-Transfused Elderly Patient Diagnosed with Beta Thalassemia Minor

Extramedullary hematopoiesis (EMH) is a compensatory reaction caused by the presence of hematopoietic precursors outside the bone marrow, ineffective erythropoiesis and patients with chronic hemolytic anemia. The most frequent cause of EMH is thalassemia intermedia, that produces an increase in demand of the hematopoietic system caused by anemia and is not reduced by transfusion therapy.
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Efficient Method of Deriving Functional Endothelial Progenitor Cells From Hematopoietic Stem Cells

EPCs (Endothelial progenitor cells) are the precursors of endothelial cells that form the inner lining of blood vessels and are involved in neovascularization and re-endothelializaton of injured tissues. These cells have the potential for treating a multitude of angiogenic disorders giving a new hope in the arena of vascular biology. In the present study, we have demonstrated that cord blood derived expanded CD34+ cells can be differentiated into functional EPCs in vitro.
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Nutritional Aspects in Heart Failure

Heart failure (HF) is a complex clinical syndrome, of a progressive character, that has a limited prognostic factor and manifested by various extracardiac aspects. It represents a serious and growing public health problem worldwide, both for its high prevalence and the severity of its clinical manifestations, being the final common pathway of most diseases. Undernutrition is often associated with HF, especially in the later stages of the disease, and may chronically reach cardiac cachexia, a severe manifestation related to poor clinical prognosis.
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Parenteral Nutrition Utilization in Bone Marrow Transplant Recipients

Bone marrow transplant (BMT) recipients often require parenteral nutrition (PN) to meet their nutrient needs. While general guidelines for the provision of PN support by nutrition support teams (NSTs) have been shown to decrease inappropriate PN use, recommendations for nutrition in BMT recipients are lacking.
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Perspectives and Potential Applications of Ruthenium-Based Nanocarriers for Cancer Therapy

Cancer is a highly heterogeneous disease characterised by continuous uncontrolled growth and expansion of abnormal cells. In general, in tumor cells the signalling pathways regulating cellular processes, as cell growth and division and cell to cellcommunication result strongly altered.
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Editorial Board Members Related to OIE

Massimo Dominici

Assistant Professor
Head Laboratory of Cell Biology and Advanced Cancer Therapies
Department of Medical and Surgical Sciences for Children & Adults
University Hospital of Modena and Reggio Emilia
Italy

Saeid Abroun

Associate Professor
School of Medicine
Tarbiat Modares University
Iran

Jonathan Scott Harrison

Professor
Division of Hematology/Medical Oncology University of Missouri
United States

Jonathan R. Keller

Principal Investigator
Hematopoiesis and Stem Cell Biology Section
Center for Cancer Research
National Cancer Institute
United States

Rammurti T. Kamble

Professor of Medicine
Baylor College of Medicine
United States

Faheem Ahmad

Assistant Professor
Department of Botany
Aligarh Muslim University
India

Jason X. Cheng

Assistant Professor
Department of Pathology, Hematopathology
University of Chicago
United states

Emmanuel Andres

Professor
Department of Internal Medicine
University Hospital of Strasbourg
France

Lan Zhou

Assistant Professor
Department of Pathology
Case Western Reserve University
United States

PREET M. CHAUDHARY

Professor
Department of Medicine
University of Southern California
United States
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