Top Links

Articles Related to TIC

Ultrasound as a New Imaging Tool to Assess Pathological Change of Joints in Preclinical Mouse Models of Osteoarthritis

Murine osteoarthritis (OA) models are important for exploring OA pathology and treatment in the pre-clinical study. Longitudinal in vivo imaging modalities, including X-ray, computed tomography, and magnetic resonance imaging, are commonly used diagnostic tools in OA clinic, while end-point histomorphometry analysis is the major outcome measurement in the pre-clinical study because clinical imaging modalities have limited resolution for small animals.
View complete article: PDF  |  Full-text

Oral Health in Asthmatics: A Review

Asthma is a chronic inflammation of airway tract characterized by airway obstruction and hyper responsiveness presenting with symptoms of wheezing, coughing, chest tightness and dyspnoea. It is a serious health issue with the worldwide occurrence. Antiasthmatic drugs have unfavorable effects on oral health causing dental caries, xerostomia, dental erosion, periodontal disease and orofacial deformities. This review concludes that asthma drastically affects oral health but preventive measures can help to improve quality of life.
View complete article: PDF  |  Full-text

Switching Darunavir/Ritonavir to Darunavir/Cobicistat in Clinical Practice Experience with 150 patients through 48 weeks

Darunavir (DRV) boosted with ritonavir (RTV) is currently among the preferred antiretroviral agents. Cobicistat (COBI), a new cytochrome P450 inhibitor is replacing RTV as pharmacoenhancer. Coformulated DRV/COBI has been approved based on bioequivalence data; however results on efficacy and safety in clinical practice are scarce. COBI inhibits creatinine tubular secretion, thus raising concerns about its renal safety.
View complete article: PDF  |  Full-text

Genetic Polymorphisms Associated with Risk of Developing Age-Related Macular Degeneration in Patients with Chronic Aspirin Usage

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly population. Aspirin usage has been reported to be associated with an increased risk of developing this disease. This study aims to determine whether the increased risk of AMD with chronic aspirin usage is related to genetic polymorphisms in the Vascular Endothelial Growth Factor A (VEGFA) and Catechol-O-Methyltransferase (COMT) genes.
View complete article: PDF  |  Full-text

Dawn of the Biofilm Disease: Highlights about Biofilm in Bone and Joint & Prosthetic Joint Infections Pathogenesis, Diagnosis and Treatment

I present some key considerations of the biofilm disease as part of two complex pathologies such as bone and joint infections and prosthetic joint infections, taking into account the bacterial pathogenic factors to understand the particular nature of these infections, and to achieve an accurate diagnosis and management beyond the antimicrobial therapy. I mention some personal experience of many years in the medical microbiology laboratory and next to the patient’s bed.
View complete article: PDF  |  Full-text

Tomotherapy Treatment of Chronic Lymphocytic Leukemia and Ocular Lymphoma

A sixty-five-years-old male patient with history of non-Hodgkin’s lymphoma of the right orbit and a fifty-years-old female patient with chronic lymphocytic leukemia with peripheral lymphocytosis were treated on TomoTherapy. In the first case, a 1 cm beam was used for planning a delivery of 30.6 Gy in 17 fractions with a sequential boost of 9 Gy in 5 fractions. Tumor involvement of the ipsilateral lens and lacrimal gland in the planning target volume necessitated a compromise between preserving patient’s vision and delivery of tumoricidal dose to the target. In the second case, 30 Gy in 20 fractions delivery was planned with a 2.5 cm beam. The tumor extended anteriorly and this technique allowed sparing more orbital tissue and required a high modulation factor.
View complete article: PDF  |  Full-text

Successful Treatment of Acquired Amegakaryocytic Thrombocytopenia (AAT) with Cyclosporine and Eltrombopag: A Case Report

Acquired amegakaryocytic thrombocytopenia is an unusual hematological disorder characterized by severe thrombocytopenia in association with a marked decrease, or the absence, of megakaryocytes in bone marrow. Its pathogenesis is not well understood and its clinical course is variable. Several treatments have been used, producing different responses. We present a case that was successfully treated with a calcineurin inhibitor combined with a thrombopoiesis-stimulating agent.
View complete article: PDF  |  Full-text

Trends in Thyroid Malignancies in Accra Ghana: A Retrospective Histopathological Review in the Department of Pathology (1994-2013), Korle-Bu Teaching Hospital

Malignancies of the thyroid gland are common in certain parts of the world. In Ghana there are no available data on the trends and gender characteristics of thyroid malignancies (TMs). The aim of this retrospective study was to determine the trends and gender characteristics of TMs in the Department of Pathology.
View complete article: PDF  |  Full-text

Computing intrinsic noise of the genetic regulation modeled by Hill functions

Intrinsic noise embedded in stochastic gene regulation due to low copy number of species has been studied using the approach of theoretical modeling and computational simulation, including the standard methods of stochastic simulation algorithm (SSA) and linear noise approximation (LNA). At average cell level, Hill functions are widely used as a compact format to represent gene regulation involving multi-transcription-factor binding and cooperativity. Heuristic SSA and LNA methods (hSSA and hLNA) have been applied to study stochastic models employing Hill functions. It is however unclear which modeling and simulation method is suitable to characterize intrinsic noise of Hill-type gene regulation with sufficient accuracy and computational efficiency. In this work, we perform noise analysis of two gene regulatory models represented by second-order activating and inhibitory Hill functions, seeking to evaluate the performance of five existing noise modeling methods.
View complete article: PDF  |  Full-text

The Efficacy and Safety of Prophylactic Fluconazole Prevent Invasive Fungal Infection in Preterm Very Low Birth Weight Infants: An Update Meta-analysis

We identified 8 eligible trials that enrolled 1392 infants. There was significant effect of prophylactic fluconazole on fungal colonization (RR, 0.31, 95%C1:-0.24 to 0.41; P<0.00001). Effect of prophylactic fluconazole on IFI in VLBW infants: RR: 0.42(95%CI 0.23 to 0.76; P=0.004.). However, prophylactic fluconazole did not reduce mortality in VLBW infants (RR 0.76, 95% CI 0.58 to 1.01; P = 0.06). Studies did not report significant adverse reactions.
View complete article: PDF  |  Full-text

Osteoid Osteoma of the Ribs - Is Image Intensifier or Bone Scintigraphy a Mandatory Diagnostic Tool - A Case report with Review of Literature

Osteoid osteoma (OO) is a benign bone tumour. In 1935, the jaffe reported it first. The fifty percent of OOs occur in long bones of the lower extremities but it may affect any bone. Only 1 % OOs affects the ribs and surgical excision was reported only in 14 cases in the literature. Complete surgical excision is the standard treatment method for osteoid osteoma is complete surgical excision which is reserved for the patients not responding to conservative treatment. In this report, we present a case of osteoid osteoma of the posterior part of the shaft of the sixth rib affecting a 30-year-old male, who had presented with symptoms of severe pain over the affected area and underwent surgical resection. Excised rib segment showed no osteosclerotic lesion on X-ray so immediately extended resection of the sixth rib was done. Here we have tried to evaluate the importance of the presence of the skeletal scintigraphy or C Arm image intensifier intraoperatively by comparing our experience with the available literature.
View complete article: PDF  |  Full-text

Envisioning Molecular Network of Obesity by Omics Stratification

To date, Obesity is considered prime concern of public health with multi-dimensional factors engaged in metabolic discrepancy that is rooted from multifactorial causes (i.e., environmental intoxication or genetic abnormality), and the unmet landscape of health care system seeks for therapeutic or preventive measures. Compelling evidence support Omics as strategic tool of systemic biology is benefit to define wiring of molecular circuit in metabolic malfunction and evaluation of metabolic modulator such as synthetic drugs, stem cell replacement, and natural secondary metabolites from various resources.
View complete article: PDF  |  Full-text

S. Pneumoniae Infection Associated with a Hemolytic Uremic Syndrome in an Adult Patient: A Case Report

Hemolytic uremic syndrome (HUS) is a rare but severe entity characterized by the triad of acute kidney injury, microangiopathic hemolytic anemia, and thrombocytopenia. This disease is frequently observed in children after a diarrhea process secondary to Escherichia coli O157: H7. However, other disturbs may generate this disease, including pneumonia secondary to S. pneumoniae, which represents around 5% of all HUS cases. This type of HUS has demonstrated an increase in incidence in the population recently.
View complete article: PDF  |  Full-text

Trial on the Efficiency of Topline® Against Natural Tick Infestations of Dromedaries in Mauritania

Topline®, as a 1% “pour-on” solution of fipronil, is produced by MERIAL Company. Fipronil is an acaricide used to control ticks and biting flies of cattle. Dromedaries are regularly infested by ticks. The effectiveness and residual activity of fipronil as a 1% w/w pour-on formulation (Topline®) was studied in a trial on ticks of calves of dromedaries near Nouakchott, Mauritania.
View complete article: PDF  |  Full-text

Mechanisms of Resistance to Kinase Inhibitors and Strategies to Prevent the Development of Drug Resistance

Targeting mutant proteins and associated signaling pathways of driver oncogenes by small molecule kinase inhibitors (KIs) are a promising strategy of cancer therapy. However, despite the initial success of treatment, KIs often become ineffective as intrinsic and acquired resistance. This article reviews the English-language literature to explore the underlying mechanisms of drug resistance and to present a challenge for developing drugs to overcome resistance. Mechanisms of acquired resistance include 1) the selection of pre-existing subclones with other mutations, 2) the emergence of secondary mutations in the target kinase domain, 3) upregulation of kinases both within the same kinase family and their related kinase families, as well as activation of alternative bypass pathways, 4) epithelial-mesenchymal transition, 5) overexpression of pro-survival Bcl-2 family proteins and 6) drug efflux mechanisms. Currently available methods are to obtain tumor biopsy samples at recurrence or progression if the tumor lesion is accessible to a biopsy and to use the second- and third-generation KIs based on the individual need of each patient. Furthermore, recent computational challenges provide design principles to prevent the development of drug resistance. In conclusion, we provide an overview of the postulated resistance mechanisms and highlight the future direction of computational structure-based design of new potent KIs.
View complete article: PDF  |  Full-text

Ordered Growth of Anodic Aluminum Oxide in Galvanostatic and Galvanostatic-Potentiostatic Modes

The results are presented of obtaining anodic aluminum oxide with an ordered pore arrangement by employing two anodizing modes - galvanostatic mode and combined (galvanostatic + potentiostatic) mode, at high values of the current density and voltage. Use has been made of an oxalate electrolyte and a complex electrolyte comprising oxalic acid and phosphoric acid. Scanning electron microscopy has been used to investigate the surface morphology of the barrier and porous layers and to determine pore sizes and inter-pore distance.
View complete article: PDF  |  Full-text

Anodizing for Design and Function

Two basic reactions occur during the anodizing of aluminum: 1) the aluminum is consumed and 2) an oxide grows. By accepting this statement as true, the anodizing process can be viewed as a corrosion process, and anodizing can be modeled using the Tafel Equation. Anodizing process parameters of electrolyte chemistry and concentration, temperature, aluminum substrate resistance and current density are presented as they relate to the Tafel Equation and how they impact the anodic aluminum oxide structure and properties. Understanding this relationship is consequent in making anodizing an engineering process, one that enables tuning the structure such that it yields distinct characteristics to fulfill design and application requirements.
View complete article: PDF  |  Full-text

Recent Developments in Human Odor Detection Technologies

Human odor detection technologies have drawn attention due to the wide possibility of potential applications they open up in areas such as biometrics, criminal investigation and forensics, search for survivors under rubble, and security checkpoint screening. Gas chromatography/mass spectrometry (GC/MS) has been the most successful and powerful analytical approach developed to date for human odor analysis, and hundreds of human odorants have been identified using this tool.
View complete article: PDF  |  Full-text

Electronic-nose Applications in Forensic Science and for Analysis of Volatile Biomarkers in the Human Breath

The application of electronic-nose (E-nose) technologies in forensic science is a recent new development following a long history of progress in the development of diverse applications in the related biomedical and pharmaceutical fields. Data from forensic analyses must satisfy the needs and requirements of both the scientific and legal communities. The type of data collected from electronic-nose devices provides a means of identifying specific types of information about the chemical nature of evidentiary objects and samples under investigation using aroma signature profiles of complex gaseous mixtures containing volatile organic compounds (VOCs) released from manufactured products and parts of the human body. E-nose analyses also provide useful qualitative information about the physicochemical characteristics and metabolic conditions of human subjects without the need for time-consuming analyses to identify all chemical components in human-derived volatile mixtures.
View complete article: PDF  |  Full-text

Analysis of Sweat Simulant Mixtures using Multiplexed Arrays of DNA-Carbon Nanotube Vapor Sensors

Carbon nanotube (NT) based electronic vapor sensors were tested against synthetic sweat solutions, consisting of 13 volatile organic compounds (VOCs) in saline, in order to probe the device ability to analyze and differentiate vapors derived from complex biological samples.
View complete article: PDF  |  Full-text

Characteristic Human Scent Compounds Trapped on Natural and Synthetic Fabrics as analyzed by SPME-GC/MS

The collection of human odor volatiles is of interest to forensic applications as a path to investigate canine scent discriminations in legal investigations. A study using a selected array of previously identified human odor compounds has been conducted to determine the retention and release capabilities of five (5) natural and synthetic fabric types, cotton (mercerized fabric and gauze matrix), polyester, rayon and wool.
View complete article: PDF  |  Full-text

The Effects of the Film Thickness and Roughness in the Anodization Process of Very Thin Aluminum Films

The anodization of aluminum foils having micrometer thickness is a common process and results in hexagonally self-ordered alumina membranes. However, anodic aluminum oxide (AAO) membranes fabricated from nanometer-thin films present new challenges to the anodization process, since aluminum films adheres poorly on supporting substrates and the smoothness of the film is highly related to the kind of substrate.
View complete article: PDF  |  Full-text

Anodic Oxidation of Titanium in Sulphuric Acid and Phosphoric Acid Electrolytes

Anodisation of pure titanium has been carried out in sulphuric and in phosphoric acid solutions at potentials ranging from 50 to 150V. The SEM and AFM morphological analysis indicates that, within this potential range, oxidation in sulphuric acid solution produces better developed mesoporous oxide layers.
View complete article: PDF  |  Full-text

Fabrication of Ordered Arrays of Anodic Aluminum Oxide Pores with Interpore Distance Smaller than the Pitch of Nano-pits formed by Ion Beam Etching

We investigated a method for preparation of ordered nanopore arrays with the interpore distance of 60 nm by guided self-organization of anodic aluminum oxide with a prepatterned array of pits in the starting Al film.
View complete article: PDF  |  Full-text

Preparation of Large Area Anodic Alumina Membranes and their Application to Thin Film Fuel Cell

The design of an electrochemical reactor for the preparation of self-supported comparatively thin (up to 10 μm) and large area (up to 50 cm2) anodic alumina membranes is described allowing growth of porous alumina at high applied potential (up to 150 V) without burning.
View complete article: PDF  |  Full-text

Fabrication of Vertical Cu2ZnSnS4 Nanowire Arrays by Two-Step Electroplating Method into Anodic Aluminum Oxide Template

Vertical Cu2ZnSnS4 (CZTS) nanowire arrays have been synthesized via two-step electroplating method into anodized aluminum oxide template. For deposition of CZTS nanowires, anodized aluminum oxide (AAO) was used as the growth mask for the growth of the nanowires. AAO templates with hole sizes of 70 nm in diameter were used in the experiments.
View complete article: PDF  |  Full-text

Fabrication and Luminescence of Anodic Alumina with Incorporated Vanadyl Citrate Chelate Anions

Anodic aluminum oxide doped with vanadyl citrate chelate complex anions was formed by a two-step self-organized anodization in 2 wt. % sulfuric acid containing 0.04 M V2O5 and 0.08 M citric acid at voltage range 13-23 V, and at 0 and 15 oC. The combination of two temperatures and at least four voltages (depending on the applied temperature) was applied as the operating conditions of anodization.
View complete article: PDF  |  Full-text

Synthesis of BaTiO3 Nanowires via Anodic Aluminum Oxide Template Method Assisted by Vacuum-and-Drop Loading

In this paper, we report on the synthesis of BaTiO3 nanowires via the anodic aluminum oxide template method. To fill in the precursors of BaTiO3 into anodic aluminum oxide templates, the vacuum and drop loading method developed in our previous study was used. Ba(CH3COO)2 (barium acetate) and C12H28O4Ti (tetraisopropyl orthotitanate) were used as Ba and Ti sources, respectively. Anodic aluminum oxide membranes with the through-hole diameter of ~200 nm were used as the template for BaTiO3 nanowires.
View complete article: PDF  |  Full-text


Editorial Board Members Related to TIC

Kelly Sullivan

Assistant Professor
Department of Neurology
University of South Florida
United States

Hassen Chaabani

Professor
Department of Human Genetics & Biological Anthropology
University of Monastir
Tunisia

QINGRONG HUANG

Professor
Department of Food Science
Rutgers University
United States

Fernando A. Herrera

Assistant Professor
Department of Surgery
Medical University of South Carolina
United States

Patrick Ilg

Associate Professor
Department of Mathematics and Statistics
University of Reading
United Kingdom

Xiaobo Zhou

Professor
Center for Bioinformatics and Systems Biology
Wake Forest University
United States

SHAUKAT ALI

Technical Support Manager
BASF Corporation
Pharma Solutions
United States

Younes Chorfi

Associate Professor
Department of Veterinary Biomedicine
University of Montreal
Canada

EHAB SAMIR AZIZ FARAG

Associate Professor
Department of General Anesthesiology
Cleveland Clinic Lerner College of Medicine
United States

Suzanne M. Miller

Professor
Division of Cancer
Fox Chase Cancer Center
United States
Submit Manuscript