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COVID-19 pandemic is a global threat, where the rate of infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) increases exponentially, and the spread of the virus from person to person is very fast. Fitting models for COVID-19 counts receive a great attention, and modelling the dispersion of COVID-19 counts helps measuring the spread of the disease in a population and evaluating the intervention

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Ameya Santhosh, Rani Alex, Vikas Vohra (2023) Comparative Assessment of De Novo Genome Assemblers for Generating Eukaryotic Primary Genome Assembly from Short Reads. J Comp Sys Bio 6(1): 101

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Leukocytoclastic Vasculitis (LCV) characterizes various small vessel vasculitis types primarily affecting the skin, with occasional internal organ involvement. This inflammation involves immune-complex deposition within dermal capillaries and venues. Although idiopathic in origin, potential triggers, including antibiotic-related factors, must be considered. LCV presents across a spectrum of severity, sometimes extending to ulcers. Diagnosis involves clinical assessment, history, lab tests, and crucially, skin biopsy.

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Acute lymphoblastic leukemia (ALL) is considered as the most common pediatric malignancy with 80% of frequency in children between 1 and 10 years old. With the evolution of science, improved diagnosis and adapted treatment, all survival rates increased to a possibility of 80%. Philadelphia chromosome like acute lymphoblastic leukemia (Ph-Like ALL) is a recent genetic discovery characterized by a gene expression profile and high frequency of IKZF1 gene alteration similar to that of BCR-ABL1 positive ALL with a poor outcome.

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Background: Gliomatosis cerebri is a rare primary brain tumor that can have extensive infiltration into the brain parenchyma. It can affect any age group and often has poor clinical outcomes. Given its unique pathology, presentation and treatment can be challenging to recognize and efficaciously treat

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Dasatinib is an orally bioavailable second generation TKI, more potent than imatinib. Bone marrow aplasia or hypoplasia secondary to TKI therapy is an uncommon adverse event. We report here the first case of chronic myeloid leukemia in chronic phase shortly treated with dasatinib that developed a prolonged bone marrow hypoplasia with concomitant response on the hematological disease with gradual improvement of the cytogenetic and molecular response after dasatinib discontinuation, without use of any other TKI therapy.

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CLCN2 related leukoencephalopathy (CC2L OMIM#: 615651) is a recently identified rare disorder, caused by autosomal recessive mutations in CLCN2 gene, leading to the dysfunction of its encoded CLC-2 chloride channel protein with characteristic brain MRI features of leukoencephalopathy

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Treatment of acute myeloid leukemia is a challenge because of the adverse drug events associated with therapy and the heterogeneous nature of the subtypes. Research on improving overall survival of patients based on different regimens, reduction of adverse dug events, clinical characteristics and the type of acute myeloid leukemia is critical.

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A 51 year old female was referred to our dermatology clinic for a rapidly growing lump on head of 6 weeks duration. On examination we observed a 15 cm diameter erythematous crusted tumor on the forehead with significant bilateral cervical lymphadenopathy. An excision biopsy of the tumor revealed a malignant high grade diffuse undifferentiated infiltrating neoplasm involving the skin and subcutaneous tissue.

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A prospective clinical cohort study covers 108 IS patients. 93 (86,1%) patients were released from the hospital with improvements, but 15 (13,9%) patients did not survive. The study was carried out in the most acute (1st day of hospitalization) and acute (7 days of hospitalization) phases of the IS. The level of interleukins in blood serum was defined by enzyme immunoassay method.

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An eight-year-old boy with Kabuki Syndrome (KS) and an enlarging CNS mass is presented. The ‘tumor’ was discovered incidentally during MR imaging for a behavioral disorder and was located within the left globus pallidus. Retrospective review of previous MRIs showed no abnormality in the basal ganglia seven years earlier but a small region (a few pixels) of increased in T2 signal intensity three years earlier.

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Asthma is a common chronic airway disease affecting about 334 million people worldwide, and an estimated 7 million children globally. Approximately 10% of patients with asthma have severe refractory disease, which is uncontrolled despite using high doses of inhaled corticosteroids and other modifiers. Among these patients are patients with eosinophilic asthma. Eosinophilic asthma is a phenotype of asthma that is usually very severe and persistent, with frequent exacerbations. It is characterized by the presence of high levels of eosinophils, and CD+4 Th2 cells in the lungs and airways. Eosinophils play a pivotal role in the pathogenesis and severity of asthma. Most patients with eosinophilic asthma respond to the classic stepwise guided treatment. However, 50% of patients with eosinophilic asthma are refractory to corticosteroids and long-acting β2-agonists. Currently, there are targeted personalized biologics for these patients. These biotherapeutics include IgE, interleukin and interleukin receptor monoclonal antibodies,they have added advantageous steroid-sparing effects.

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The purpose of the study was to evaluate the management of patients treated with Imatinib for Chronic Myeloid Leukemia (CML) in the Department of Clinical Hematology of the Yalgado OUEDRAOGO University Hospital in Ouagadougou, Burkina Faso.

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Anaplastic large cell lymphoma with a small cell pattern is a rare T-cell lymphoma. This condition is frequently seen in young patients and should be considered in patients presenting with leucocytosis and constitutional symptoms. We report a case of small cell variant (SCV) of ALCL in a 68 year old man diagnosed by ALK immunohistochemistry (IHC) and cytogenetic analysis. The limitations of using only morphology in diagnosing this rare variant, has also been emphasised.

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India has been acclaimed for the extent diversity especially in the context of cast, culture, languages, religion, and scripts.

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The results are presented of obtaining anodic aluminum oxide with an ordered pore arrangement by employing two anodizing modes - galvanostatic mode and combined (galvanostatic + potentiostatic) mode, at high values of the current density and voltage. Use has been made of an oxalate electrolyte and a complex electrolyte comprising oxalic acid and phosphoric acid. Scanning electron microscopy has been used to investigate the surface morphology of the barrier and porous layers and to determine pore sizes and inter-pore distance.

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The collection of human odor volatiles is of interest to forensic applications as a path to investigate canine scent discriminations in legal investigations. A study using a selected array of previously identified human odor compounds has been conducted to determine the retention and release capabilities of five (5) natural and synthetic fabric types, cotton (mercerized fabric and gauze matrix), polyester, rayon and wool.

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Anodic aluminum oxide doped with vanadyl citrate chelate complex anions was formed by a two-step self-organized anodization in 2 wt. % sulfuric acid containing 0.04 M V2O5 and 0.08 M citric acid at voltage range 13-23 V, and at 0 and 15 oC. The combination of two temperatures and at least four voltages (depending on the applied temperature) was applied as the operating conditions of anodization.

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In this paper, we report on the synthesis of BaTiO3 nanowires via the anodic aluminum oxide template method. To fill in the precursors of BaTiO3 into anodic aluminum oxide templates, the vacuum and drop loading method developed in our previous study was used. Ba(CH3COO)2 (barium acetate) and C12H28O4Ti (tetraisopropyl orthotitanate) were used as Ba and Ti sources, respectively. Anodic aluminum oxide membranes with the through-hole diameter of ~200 nm were used as the template for BaTiO3 nanowires.

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